Publications by authors named "Xian Meng Wu"
Despite the development of HER2-targeted drugs, achieving favorable outcomes for patients with HR+/HER2+MBC remains challenging. This study utilized Bayesian Network Meta-analysis to compare the efficacy and safety of anti-HER2 combination regimens. The primary analysis focused on progression-free survival (PFS), while secondary analyses included objective response rate, overall survival (OS) and the incidence rate of grade 3/4 adverse events (AEs).
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- The study focuses on the transcriptional regulatory region of the FAD2 gene in Brassica napus, specifically examining a gene labeled BnFAD2A5-1 found on chromosome A5.
- It was discovered that the gene includes a 1,192 bp intron in its 5'-untranslated region (5'-UTR) that actually has promoter activity, influencing the gene's expression.
- Through deletion analysis, researchers identified key regions of the promoter necessary for high transcription levels, as well as factors like light, low temperature, and ABA that induce the expression of BnFAD2 transcripts.