Context: Obesity, one of the major public health problems worldwide, has attracted increasing attention. Ginsenoside Rb1 is the most abundant active component of C.A.
* In this study, HO treatment led to a significant reduction in the mitochondrial distribution of various miRNAs in human umbilical vein endothelial cells, with miR-301a-3p showing the most significant changes.
* The study identified that the RNA-binding protein Musashi RNA binding protein 2 (MSI2) interacts specifically with miR-301a-3p, influencing its distribution between the cytosol and mitochondria, especially under HO conditions, highlighting MSI2's role in miRNA regulation.