Publications by authors named "Xian Liang Duan"
Objective: To explore the safety and efficacy of metastatic osteosarcoma treatment with combined sintilimab injection and chemotherapy.
Methods: We performed a retrospective analysis of 32 patients with metastatic osteosarcoma admitted to the Affiliated Hospital of Beihua University between January 2019 and June 2020. The sample was divided into an observation group, treated with sintilimab injection combined with chemotherapy (n= 16) and a control group, treated with chemotherapy (n = 16).
Osteosarcoma (OS) is a malignant disease with high morbidity and mortality rates in children and adolescents. Evidence has indicated that long non‑coding RNAs (lncRNAs) may serve important roles in human cancer progression, including OS. In the present study, the role of lnc‑double homeobox A pseudogene 8 (DUXAP8) in the development of OS was identified.
View Article and Find Full Text PDFExploring the mechanisms of the combination therapy using VEGFR-TKI and immune checkpoint inhibitors might be useful to control the development of osteosarcoma. The expression of PD-L1 and STAT3 in osteosarcoma were determined with western blot. Proliferation, migration and invasion were determined with CCK-8 and Transwell assays.
View Article and Find Full Text PDFAcute Myeloid Leukemia (AML) is a cancer of hematopoietic stem cells with a rapid progression. Recent studies indicated that endocrine disruptor chemicals (EDCs) are potential risk factors for AML progression. Our present data showed that an industrial endocrine disrupting chemical, Benzyl butyl phthalate (BBP), can promote the proliferation of AML cells and decrease their sensitivity to daunorubicin (DNR) and cytarabine (Ara-C) treatments.
View Article and Find Full Text PDF[Expression of FANCG gene in acute myeloid leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2013
Article Synopsis
- * Results showed that FANCG mRNA levels were significantly lower in newly diagnosed AML patients compared to those in complete remission (CR) and healthy controls, suggesting a potential link between this gene and the onset of AML.
- * There was no significant difference in FANCG expression between the AML CR group and control group, indicating that while FANCG may relate to AML onset, it could also be important for assessing chemotherapy effectiveness.