Low Expression Levels of CXCL12, CXCR4, and CXCR 7 in Peripheral Blood and Decidual Tissues are Associated with Miscarriage in Women.

Miscarriage can cause significant physical and psychological harm to women. The stromal cell-derived factor 1 (SDF-1, also known as CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) and C-X-C motif chemokine receptor 7 (CXCR7) axis can promote the proliferation and invasion of trophoblast cells in early pregnancy, and maintain immune tolerance at the maternal-fetal interface to aid with pregnancy success. From our findings, the serum CXCL12 level of women who have miscarried (n = 25) was significantly lower than that of healthy early pregnancy women (n = 20) by ELISA ( < .

STX2 Promotes Trophoblast Growth, Migration, and Invasion Through Activation of the PI3K-AKT Pathway in Preeclampsia.

Objectives: Abnormal trophoblast behaviors during pregnancy contribute to the development of preeclampsia (PE). Syntaxin2 (STX2) has been shown to be a crucial epithelial mediator in numerous diseases. However, the functions of STX2 and the mechanisms underlying its role in PE remain largely unknown.

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients.

Objective: To examine the clinicopathologic characteristics and clinical features of epithelial tumors of lacrimal gland in China.

Methods: The retrospective case series study included all 298 patients of epithelial lacrimal gland tumors which had been collected in the ophthalmic pathologic laboratory of the Tongren Hospital Beijing in the study period from 1961 to 2005.

Results: Pleomorphic adenomas were the most common tumors (n = 213 (72%)), followed by adenoid cystic carcinoma (n = 58 (20%)), pleomorphic adenocarcinoma (n = 13 (4%)), primary adenocarcinoma (n = 8 (3%)) and other tumors (n = 6 (2%)).

Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006.

Background And Objective: To examine the spectrum of eyelid neoplastic specimens obtained at the Beijing Tongren Eye Centre between 1997 and 2006.

Patients And Methods: A total of 2,639 eyelid neoplasms were included in the study.

Results: Of the 2,639 eyelid specimens, 2,276 (86.

[Clinical and pathological analysis of 2639 cases of eyelid tumors].

Objective: To describe the histopathologic spectrum and patient characteristics of eyelid tumors in Beijing Tongren Hospital.

Methods: It was a claims database analysis. A total of 2639 eyelid tumors verified histopathologically from January 1997 to December 2006 were included in the study.

[Study on the risk factors for optic nerve invasion in 381 cases of retinoblastoma].

Objective: To investigate the clinical and pathologic outcomes of a large group of retinoblastoma (RB) cases to ascertain the risk factors of RB optic nerve invasion.

Methods: In this paper, we summarized the clinical and pathologic data of 381 retinoblastoma cases in Beijing Tongren Hospital observed from 1990 to 2002. Statistical analyses were performed on the sex, age, unilateral or bilateral cases, length of symptoms, clinical situation, stage, histological type and the degree of optic nerve invasion.

[Recognize the value of the individually combined therapy for children with retinoblastoma].

Retinoblastoma is the most common intraocular malignant tumor in children. With the introduction of the new therapeutic methods, the aim and the procedures of traditional therapy on retinoblastoma have been changed to the new combined therapeutic procedures, which are based on the preservation of the eyeball and visual function. Compared with the developed countries, there still exist some gaps in the acceptance of new therapeutic conceptions in China.

[Clinical use of quantitative DNA pathologic examination in eye neoplasms].

Quantitative DNA pathologic examination is an important content of quantitative pathology, which is to use cytochemistry quantitative analytical technique for quantitative analysis of patho-histological structure and intra-cellular DNA level. Quantitative determination of DNA in tumor cells as an objective quantitative index reflecting biological behavior of tumor cells and has an important significance for distinguishing precancerous lesions, borderline tumors, benign and malignant tumors; and for estimating the malignant degree and prognosis. This review introduces the study about DNA quantitative analysis used in clinical pathology of eye neoplasms.

[Clinical and pathological features of 112 cases with ocular adnexal lymphoproliferative lesions].

Objective: To investigate the histopathological classification and clinical features of ocular adnexal lymphoproliferative lesions.

Methods: The clinical, histomorphological and immuno-histochemical features of 112 cases of ocular adnexal lymphoproliferative lesions (116 paraffin specimens) were studied retrospectively. The lesions were classified according to the World Health Organization classification of tumors of haematopoietic and lymphoid tissues (2001).

[A five-year overview of basic and clinical research of ophthalmic pathology in China].

This paper briefly reviews the growth and development over the past five years in relation to the work of Pathology Division of Chinese Society of Ophthalmology. In connection with major constitute member organizations of the Division, it depicts their key research areas, major projects undertaken and outcome of achievement, the progress in their research team building and talent nurture programs, as well as their publication status. It also summarily reports the important basic and clinical research carried out on ophthalmic pathology, ophthalmic tumors, ophthalmic orbital diseases, and in other various relevant fields.

[Clinical significance of mdm2 and p53 expression in orbital rhabdomyosarcoma].

Objective: To evaluate the role of oncogene mdm2 and p53 in the development of orbital rhabdomyosarcoma (ORMS) and demonstrate the feasibility of mdm2 and p53 as biological characteristic markers and prognostic indicators.

Methods: Immunostainings of mdm2, p53 and Ki-67 antigen were performed on archival paraffin-embedded tissues taken from 31 ORMS patients. In situ hybridization was used to demonstrate the expression of mdm2 and p53 on the mRNA level.

[The study on the correlation between telomerase and histopathologic features of retinoblastoma].

Objective: To investigate the correlation between the expression of human telomerase RNA (hTR), human telomerase reverse transcriptase (hTRT) and the proliferation and differentiation of retinoblastoma (RB).

Methods: In 37 RB specimens, the expression of hTR and hTRT was investigated with the methods of in situ hybridization (ISH). Immunohistochemical method was performed to detect the expression of proliferating cell nuclear antigen (PCNA) in RB.

[Clinical and pathological features of 273 cases of lacrimal epithelial tumors].

Objective: A retrospective study of histopathological and clinical aspects of 261 cases of lacrimal tumors (273 paraffin specimens) from Ophthalmic Pathology Laboratory, Beijing Tongren Hospital (Dec. 1961 to Jun. 2002) was performed to investigate the pathological classification and clinical features of these tumors.

Telomerase expression in sebaceous carcinoma of the eyelid.

Background: In humans telomerase is expressed in most cancers and immortal cell lines, and activation of telomerase may play important roles in tumorigenesis and immortalization. This study was to investigate the roles of telomerase activity (TA) and human telomerase RNA (hTR) in sebaceous carcinoma of the eyelid.

Methods: The telomerase repeated amplification protocol (TRAP) was used to demonstrate telomerase activity in 12 cases of sebaceous carcinoma of the eyelid.

[Clinical and pathologic analysis of orbital pseudotumor].

Objective: To investigate the relationship between the histopathology and the imaging analysis of orbital pseudotumor to judge the histopathological types of these tumors before treatment according to imaging analysis, in order to search for different therapeutic approaches for different pathologic types and to predicate prognosis.

Methods: Fifty-six cases (58 eyes) of orbital pseudotumor that had been operated in Tongren hospital were studied. The clinical manifestations of these patients were reviewed.

[Correlation of tumor angiogenesis with clinicopathologic prognostic parameters in choroidal melanoma].

Objective: Tumor angiogenesis is an essential step for tumor growth, progression and metastasis. Vascular endothelial growth factor (VEGF) is a mitogen specific for vascular endothelial cells, and plays a key role in tumor angiogenesis. The purpose of the present study was to investigate the expression of VEGF mRNA and VEGF protein in choroidal melanoma and to correlate these factors and the microvessel density (MVD) with the clinicopathologic prognostic features.