Parechovirus A infection and risk of gastroenteritis in children: A systematic review and meta-analysis.

Parechovirus A (PeV-A) belongs to the genus Parechovirus in the family Picornaviridae associated with gastroenteritis illness, particularly in children, but prior studies have produced ambiguous results. This study aimed to provide a systematic review of the PeV-A prevalence in paediatric patients with gastroenteritis and the association between PeV-A infection and the risk of gastroenteritis. A systematic search of the literature was conducted in Embase, PubMed, Scopus, and Web of Science, in combination with the reference lists of potentially relevant articles.

Electrochemical behavior of 2205 duplex stainless steel in simulated solution containing high concentration Cl and saturated CO at different temperatures.

2205 duplex stainless steel (DSS) has good corrosion resistance due to its typical duplex organization, but the increasingly harsh CO-containing oil and gas environment leads to different degrees of corrosion, especially pitting corrosion, which seriously threatens the safety and reliability of oil and gas development. In this paper, the effect of temperature on the corrosion behavior of 2205 DSS in a simulated solution containing 100 g/L Cl and saturated CO was investigated with immersion tests and electrochemical tests and combined with characterization techniques such as laser confocal microscopy and X-ray photoelectron spectroscopy. The results show that the average critical pitting temperature of 2205 DSS was 66.

Effects of Tenofovir Combined with Recombinant Human Interferon -2b on Negative Conversion Rate, Liver Function, Immune Status, and Drug Safety in Patients with Chronic Hepatitis B: A Systematic Review and Meta-Analysis.

Objective: To systematically evaluate the clinical value of tenofovir combined with recombinant human interferon -2b in the treatment of chronic hepatitis B and to provide evidence-based medicine for its popularization and use.

Methods: The randomized controlled trials (RCTs) of tenofovir combined with recombinant human interferon -2b in the online database of PubMed, EMBASE, ScienceDirect, Cochrane Library, China knowledge Network (CNKI), China VIP database, Wanfang database, and China Biomedical Literature Database (CBM) were searched. The data included in this study were extracted by two independent researchers.

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.

The small nucleolar RNA (snoRNA) is a type of small non-coding RNA widely distributed in the nucleoli of eukaryotic cells, promoting cancer development. The aim of this study was to assess box C/D snoRNA 89 (SNORD89) dysregulations in endometrial cancer. According to the TCGA database as well as the International Federation of Gynecology and Obstetrics (FIGO), higher SNORD89 expression is found in endometrial cancer tissues.

Synthesis of Linear to Cyclic Polylactide a One-Pot Step-Wise Ring-Opening Polymerization and Back-Biting Reaction of Ring Closure Using Magnesium Complexes.

The controllable synthesis of cyclic polylactide remains a challenging topic so far. In this work, a new strategy of one-pot step-wise ring-opening polymerization (ROP) followed by a back-biting reaction of ring closure was reported, in which one magnesium atrane-like complex {,-bis[3,5-di-cumyl-2-benzyloxy]-[2-(2-aminoethoxy)ethoxy]magnesium} was utilized to initiate the ROP of lactide using 4-dimethylaminopyridine as a co-catalyst; then, macrocyclic polylactides were liberated out increasing temperature after complete depletion of the monomer in which a back-biting reaction was utilized as a ring-closure method. The living feature at the first ROP stage can be proved well by the controllable molecular weights ranging from 3.

Silica-templated photonic crystal sensors for specific detection of Cu.

Responsive photonic crystals have attracted extensive attention due to their features of transforming external stimuli into a variation of optical signals or structural colors. In recent years, the accumulation of heavy metal ions has become a serious threat to human health and the environment. Thus, a simple and rapid method for the accurate detection of metal ions is of great importance.

Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study.

Context: Evidence has shown maternal androgen levels in both the general population and populations with hyperandrogenic disorders are inversely associated with offspring birth weight.

Context: We aimed to investigate the causal effect of maternal testosterone levels in the general population on offspring birth weight and preterm delivery risk using a two-sample Mendelian randomization (MR) method.

Methods: We obtained independent genetic instruments from a sex-specific genome-wide association study with up to 230 454 females of European descent from the UK Biobank.

Effects of Elephantopus scaber extract on growth, proximate composition, immunity, intestinal microbiota and resistance of the GIFT strain of Nile tilapia Oreochromis niloticus to Streptococcus agalactiae.

This study aimed to investigate the effects of Elephantopus scaber extract on the GIFT (genetic improvement of farmed tilapia) strain of Nile tilapia Oreochromis niloticus. A total of 800 tilapia with an initial body weight of 1.34 ± 0.

SGLT2 inhibitor dapagliflozin attenuates cardiac fibrosis and inflammation by reverting the HIF-2α signaling pathway in arrhythmogenic cardiomyopathy.

Excessive cardiac fibrosis and inflammation aberrantly contribute to the progressive pathogenesis of arrhythmogenic cardiomyopathy (ACM). Whether sodium-glucose cotransporter-2 inhibitor (SGLT2i), as a new hypoglycemic drug, benefits ACM remains unclear. Cardiomyocyte-specific Dsg2 exon-11 knockout and wild-type (WT) littermate mice were used as the animal model of ACM and controls, respectively.

Immunotherapy in non-small cell lung cancer: rationale, recent advances and future perspectives.

Lung cancer, with non-small cell lung cancer (NSCLC) being the major type, is the second most common malignancy and the leading cause of cancer-related death globally. Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has been one of the greatest advances in recent years for the treatment of solid tumors including NSCLC. However, not all NSCLC patients experience an effective response to immunotherapy with the established selection criteria of programmed death ligand 1 (PD-L1) and tumor mutational burden (TMB).

Deriving the Hawking Temperature of (Massive) Global Monopole Spacetime via a Topological Formula.

In this work, we study the Hawking temperature of the global monopole spacetime (non-spherical symmetrical black hole) based on the topological method proposed by Robson, Villari, and Biancalana (RVB). By connecting the Hawking temperature with the topological properties of black holes, the Hawking temperature of the global monopole spacetime can be obtained by the RVB method. We also discuss the Hawking temperature in massive gravity, and find that the effect of the mass term cannot be ignored in the calculation of the Hawking temperature; the corrected Hawking temperature in massive gravity can be derived by adding an integral constant, which can be determined by the standard definition.

Efficacy and safety of acupuncture as a complementary therapy for sepsis: a systematic review and meta-analysis.

Background: Sepsis is a life-threatening organ dysfunction caused by dysregulation of the host response to infection. Acupuncture is used for treatment of inflammatory diseases; however, its effectiveness and safety as a complementary therapy for sepsis has not been fully explored.

Methods: Data were retrieved from eight databases.

Nickel metal-organic frameworks for visible-light CO reduction under mild reaction conditions.

Photochemical CO conversion into carbon fuel is a promising route to explore renewable energy and relieve climate change. However, it is still a key challenge to achieve high selectivity to CO and simultaneously achieve high conversion efficiency in photochemical CO reduction. Herein, we demonstrate the effect of Ni metal centers as catalytic active sites for the photocatalytic conversion of CO to CO by designing and constructing Ni metal-organic framework (Ni-MOF) materials.

Skin bacterial richness and diversity in intensive care unit patients with severe pneumonia.

Objectives: Patients with severe pneumonia admitted to the intensive care unit (ICU) have a high risk of mortality, and the microbiome is likely to affect the outcome of such patients. However, the composition of the skin microbiota of ICU patients with severe pneumonia remains unclear. In this study, on the basis of 16S ribosomal ribonucleic acid sequencing, we explored the difference in skin bacterial richness and diversity between the ICU patient group (PG) with severe pneumonia and the healthy control group (CG).

Long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis.

Background: Long noncoding RNAs (lncRNAs) are emerging as master regulators for gene expression and thus play a vital role in human tumorigenesis and progression. But the involvement of novel lncRNAs in non-small cell lung cancer (NSCLC) remains largely unelucidated.

Methods: A total of 170 NSCLC and their adjacent non-tumor tissues were enrolled to detect the expression of Lnc-LSAMP-1 by RT-qPCR.

Visits of concern in child neurology telemedicine.

Aim: To characterize child neurology telemedicine visits flagged as requiring in-person evaluation during the COVID-19 pandemic.

Method: We analyzed 7130 audio-video telemedicine visits between March and November 2020. Visits of concern (VOCs) were defined as telemedicine visits where the clinical scenario necessitated in-person follow-up evaluation sooner than if the visit had been conducted in-person.

Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design.

Microtubules consisting of α- and β-tubulin heterodimers have proven to be an efficient drug target for cancer therapy. A broad range of agents, including ELR510444 and parbendazole, can bind to tubulin and interfere with microtubule assembly. ELR510444 and parbendazole are colchicine binding site inhibitors with antiproliferative activities.

COVID-19 vaccine acceptance among cold-chain workers in Shenzhen, China: A cross-sectional survey.

Given the high level of exposure to SARS-CoV-2, cold-chain workers are considered priority vaccination groups. To date, many studies have reported on the willingness within distinct populations to be vaccinated against COVID-19, whereas it has not been reported among cold-chain workers worldwide. To address this void, we conducted a cross-sectional survey to gather general information, COVID-19-related knowledge, attitudes, and practices (KAP), and willingness to receive a COVID-19 vaccine among cold-chain workers in Shenzhen, China.

Two novel and efficient plant composites for the degradation of oxytetracycline: nanoscale ferrous sulphide supported on rape straw waste.

As a biomass waste, rape straw shows a good application prospect in heterogeneous catalyst preparation due to its low-cost and stable structure. In this study, FeS-modified rape straw (RS-FeS) and its biochar (RSBC-FeS) were firstly synthesized to remove oxytetracycline (OTC). The highest OTC removal capacities observed for RS-FeS and RSBC-FeS were 635.

Computational analysis of neurodevelopmental phenotypes: Harmonization empowers clinical discovery.

Making a specific diagnosis in neurodevelopmental disorders is traditionally based on recognizing clinical features of a distinct syndrome, which guides testing of its possible genetic etiologies. Scalable frameworks for genomic diagnostics, however, have struggled to integrate meaningful measurements of clinical phenotypic features. While standardization has enabled generation and interpretation of genomic data for clinical diagnostics at unprecedented scale, making the equivalent breakthrough for clinical data has proven challenging.

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade.

Differentiation blockade is a hallmark of acute myeloid leukemia (AML). A strategy to overcome such a blockade is a promising approach against the disease. The lack of understanding of the underlying mechanisms hampers development of such strategies.

Preoperative Prediction of Malignant Transformation of Sinonasal Inverted Papilloma Using MR Radiomics.

Purpose: Accurate preoperative prediction of the malignant transformation of sinonasal inverted papilloma (IP) is essential for guiding biopsy, planning appropriate surgery and prognosis of patients. We aimed to investigate the value of MRI-based radiomics in discriminating IP from IP-transformed squamous cell carcinomas (IP-SCC).

Methods: A total of 236 patients with IP-SCC (n=92) or IP (n=144) were enrolled and divided into a training cohort and a testing cohort.