Publications by authors named "Xian Huang"

Mechanoreceptors in animals and plants play a crucial role in sensing mechanical stimuli such as touch, motion, stretch, and vibration. Learning from the mechanisms of mechanoreceptors may facilitate the development of bionic tactile sensors, leading to higher sensitivity, spatial resolution, and dynamic ranges. However, very little literature has comprehensively discussed the relevance of biological tactile sensing systems and machine-learning-based bionic tactile sensors.

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The achievement of flexible skin electrodes for dynamic monitoring of biopotential is one of the challenging issues in flexible electronics due to the interference of large acceleration and heavy sweat that influence the stability of skin-electrode interfaces. This work presents materials and techniques to achieve self-healing and shear-stiffening electrodes and an associated flexible system that can be used for multichannel biopotential measurement on the skin. The electrode that is based on a composite of silver (Ag) flakes, Ag nanowires, and polyborosiloxane offers an electrical conductivity of 9.

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  • Wound healing research is crucial for understanding conditions like fibrosis, but the link between skin microbiota and fibrosis is not well understood.
  • The study focuses on keloids, a challenging fibrotic skin disease, and shows the presence of microbiota in keloid tissues, revealing differences in microbial composition compared to normal skin.
  • Findings indicate elevated levels of IL-8, which promotes collagen accumulation and fibroblast movement, suggesting that targeting commensal bacteria and IL-8 signaling could be key in treating recurrent keloid disease.
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Background: This study investigates the distribution and characteristics of linezolid and vancomycin susceptibilities among Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) and explores the underlying resistance mechanisms.

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Objective: This study aims to report two unrelated individuals with the same novel CisAB blood type and confirm this rare blood type using a comprehensive approach that combines serological and molecular biology techniques.

Methods: Peripheral blood samples were collected from two patients and their family members. ABO blood typing and antibody detection were performed using conventional tube methods.

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Purpose: This study aimed to investigate the association between unilateral high-riding vertebral artery (HRVA) and morphological changes in the atlantoaxial joint (AAJ) and to determine whether unilateral HRVA is a risk factor for atlantoaxial osteoarthritis (AAOA).

Methods: We conducted a retrospective analysis of 2496 patients admitted to our medical center between January 2020 and December 2022 who underwent CT imaging of the cervical spine. Two hundred and seventy-two patients with unilateral HRVA (HRVA group) were identified and a respective 2:1 age- and sex-matched control group without HRVA was built.

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Fibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co‑receptor β‑klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the gene via ultrasound‑targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post‑acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients and rats with heart dysfunction post‑infarction were determined using ELISA.

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Continuously monitoring neurotransmitter dynamics can offer profound insights into neural mechanisms and the etiology of neurological diseases. Here, we present a miniaturized implantable fluorescence probe integrated with metal-organic frameworks (MOFs) for deep brain dopamine sensing. The probe is assembled from physically thinned light-emitting diodes (LEDs) and phototransistors, along with functional surface coatings, resulting in a total thickness of 120 μm.

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  • The study aimed to analyze a rare B(A) blood subtype in a female subject and her family, focusing on its genetic and serological characteristics, as well as potential transfusion strategies.
  • Serological tests revealed inconsistent blood typing results for the subject, and sequencing identified eight specific mutations linked to the BA.02 blood type in both the female subject and her son.
  • The findings suggest that determining B(A) subtypes requires a combination of genetic testing and family history analysis, rather than relying solely on serological methods, as each case may present uniquely.
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Phenols such as bisphenols, parabens, and triclosan are common environmental endocrine disruptors. Previous epidemiological studies have suggested that phenols may affect semen quality, but the results were inconsistent. In addition, most existing studies have been limited to the effects of a single chemical compound, ignoring the health effects of mixed exposure to multiple chemicals.

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The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing a principal components analysis-based approach, we differentiated the mice into extinction-resistant and susceptible groups. We determined that elevated synapsin 2a (Syn2a) in the infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading to an excitatory/inhibitory imbalance in the BLA region and causing extinction resistance.

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Background: Delayed or missed doses are inevitable in epilepsy pharmacotherapy. The current remedial measures recommended by the United States Food and Drug Administration (FDA) for non-adherence are generic and lack clinical evidence.

Aim: To assess remedial strategies for delayed or missed pregabalin doses in patients with epilepsy using Monte Carlo simulations.

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  • Researchers designed new inhibitors (C6-PyraP-BP and C2-Pur-BP) targeting human geranylgeranyl pyrophosphate synthase (hGGPPS) to combat multiple myeloma, pancreatic ductal adenocarcinoma, and colorectal cancer.
  • The C6-PyraP-BP inhibitor RB-07-16 showed promising results in reducing tumor growth in mouse models without significant liver damage, indicating a good safety profile.
  • The study supports further development of these pyrazolo[3,4-]pyrimidine-based inhibitors as potential treatments for various cancers.
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Liquid metals with metallic conductivity and infinitely deformable properties have tremendous potential in the field of conformal electronics. However, most processing methods of liquid metal electronics require sophisticated apparatus or custom masks, resulting in high processing costs and intricate preparation procedures. This study proposes a simple and rapid preparation method for patterned liquid-metal-enabled universal soft electronics (PLUS-E).

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  • The study investigates the prognostic significance of the albumin/fibrinogen ratio (AFR) and the admission Hunt-Hess (HH) score in predicting outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH).
  • Researchers analyzed data from 112 aSAH patients to identify independent risk factors affecting their 6-month outcomes.
  • Results indicate that a low AFR, combined with the HH score, enhances the prediction of unfavorable outcomes compared to using each measure individually.
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Methods to manipulate magnetic beads are essential factors to determine the efficiency and dimension of an in vitro diagnostic system. Currently, using movable permanent magnets and planar electromagnets is still the major approach to achieve magnetic bead control, causing significant constraint in the miniaturization of in vitro diagnostic systems. Here, we propose techniques to construct a fully integrated microfluidic device that can conduct automatic magnetic bead manipulation as well as rapid chemical reaction and cleaning in a minimized dimension similar to a USB disk.

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Lithium (Li) metal is a promising anode candidate for high-energy-density batteries owing to its high theoretical capacity and low electrochemical potential. However, uneven Li nucleation, uncontrollable dendritic growth, infinite voltage change and even safety issues hinder its commercial application. Herein, a three-dimensional (3D) framework of freestanding vanadium nitride nanowires (VN NWs) is established as Li host for dendrite-free Li metal anode.

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Objectives: To develop an end-to-end deep neural network for the classification of contrast-enhanced mammography (CEM) images to facilitate breast cancer diagnosis in the clinic.

Methods: In this retrospective mono-centric study, patients who underwent CEM examinations from January 2019 to August 2021 were enrolled. A multi-feature fusion network combining low-energy (LE) and dual-energy subtracted (DES) images and dual view, as well as bilateral information, was trained and tested using a large CEM dataset with a diversity of breast tumors for breast lesion classification.

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  • A new MRI-safe implantable wireless energy harvester has been created to help patients with brain disorders, hearing issues, and heart arrhythmias while addressing risks associated with rigid magnets in existing devices.
  • The innovative system features a flexible, omnidirectional rotating magnetic array that allows miniaturized magnetic balls to rotate freely within cavities, generating a strong magnetic force for energy transfer.
  • This technology could enable long-lasting, flexible, and battery-free implantable devices, enhancing methods for monitoring and treating both acute and chronic health conditions.
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Real-time glucose monitoring conventionally involves non-bioresorbable semi-implantable glucose sensors, causing infection and pain during removal. Despite bioresorbable electronics serves as excellent alternatives, the bioresorbable sensor dissolves in aqueous environments with interferential biomolecules. Here, the theories to achieve stable electrode potential and accurate electrochemical detection using bioresorbable materials have been proposed, resulting in a fully printed bioresorbable electrochemical device.

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Flexible thermoelectric (TE) devices offer great potential for wearable thermal management and self-powered systems, but heat dissipation and electrical interconnection remain key challenges. In this study, we address these issues by integrating flexible TE devices with phase-change material (PCM) heatsinks and stretchable semi-liquid metal (semi-LM) interconnectors. The effectiveness of PCMs with varying melting points for temperature regulation in different environmental conditions is demonstrated, delivering cooling effects exceeding 10 °C.

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Precisely delivering light to multiple locations in biological tissue is crucial for advancing multiregional optogenetics in neuroscience research. However, conventional implantable devices typically have rigid geometries and limited light sources, allowing only single or dual probe placement with fixed spacing. Here, a fully flexible optogenetic device with multiple thin-film microscale light-emitting diode (µ-LED) displays scattering from a central controller is presented.

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fabrication of wearable devices through coating approaches is a promising solution for the fast deployment of wearable devices and more adaptable devices for different sensing demands. However, heat, solvent, and mechanical sensitivity of biological tissues, along with personal compliance, pose strict requirements for coating materials and methods. To address this, a biocompatible and biodegradable light-curable conductive ink and an all-in-one flexible system that conducts injection and photonic curing of the ink as well as monitoring of biophysiological information have been developed.

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Synopsis of recent research by authors named "Xian Huang"

  • - Xian Huang's recent research focuses on advancing bionic tactile sensors, wearable biopotential monitoring devices, and understanding the role of microbiomes in skin fibrosis, promoting interdisciplinary approaches combining biology, materials science, and engineering.
  • - Key innovations include the development of self-healing skin electrodes for enhanced performance in biopotential measurement and the creation of flexible tactile sensors inspired by bio-mechanoreceptors, both aiming to improve the sensitivity and functionality of wearable devices.
  • - Additionally, Huang has explored the molecular epidemiology of antibiotic-resistant bacteria, the dynamics of neurotransmitter sensing in the brain, and the mechanics of skin diseases, showcasing a commitment to addressing major health issues through collaborative scientific research.

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