Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.

Purpose: To investigate the therapeutic benefits of Hydroxysafflor yellow A (HSYA) on blood-brain barrier (BBB) vulnerability after traumatic brain injury (TBI) and identify its potential action of mechanisms on TBIinduced injuries.

Methods: The rat TBI model was performed by using a controlled cortical impact device. The BBB permeability induced by TBI was measured through Evans Blue dye superflux and western blotting or polymerase chain reaction (PCR) for tight junctional proteins (TJPs).

Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice.

Background: In our preliminary study, we screened for their potential to inhibit 5α-reductase, and (MF) extract showed the most potent activity as confirmed by high-performance liquid chromatography (HPLC).

Objective: This study aimed to investigate the effects of MF extract on 5α-reductase activity and its mechanisms of action in the prevention or treatment of androgenetic alopecia.

Methods: HPLC was used to measure 5α-reductase activity.

Antiobesity Effect of Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice.

Franch. et Savat. (AC) has been used in traditional medicine for the treatment of chronic bronchitis, arthralgia, and gastralgia.

CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance.

Objectives: Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines.

[The role of food-specific IgG antibody test in diagnosis and treatment of mild recurrent aphthous ulcer].

Purpose: To evaluate the role of food-specific IgG antibody test in the treatment of mild recurrent aphthous ulcer.

Methods: Seven hundred and ninety nine mild recurrent aphthous ulcer patients and 762 normal persons were enrolled in the experimental and control group respectively, based on the criteria for inclusion and exclusion. The blood serum samples of them were obtained to detect food-specific IgG antibody by enzyme-linked immunosorbent assay.

[Changes of cementum endotoxin levels in different teeth with periodontitis treated with root conditioning].

Purpose: To observe the changes of endotoxin levels after different teeth with periodontitis were treated with different methods. METHODS： Six healthy premolars extracted for orthodontic reasons and 36 posterior teeth extracted due to severe periodontitis were selected. Each tooth was processed from two 4 mm×4 mm×1 mm cementum pieces 2 mm under the cementum-enamel junction, each tooth with periodontitis was numbered.

Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus solitarius of obese mice.

Metformin is widely used to treat obese diabetics because of its beneficial effects on body weight, energy intake, and glucose regulation. However, it has not been investigated how oral metformin affects meal patterns, or whether the reduced food intake is associated with neuronal activation in the hindbrain. Accordingly, we investigated how orally administered metformin (150 or 300 mg/kg daily for 4 or 7 days) reduces body weight in obese mice on a high-fat diet by continuously measuring meal patterns, energy expenditure, and locomotor activity, and whether oral metformin (300 mg/kg daily for 3 days) increases c-Fos expression in the nucleus tractus solitarius (NTS) and area postrema.

Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation.

Resveratrol (3,4,5-trihydroxy-trans-stilbene), a phytoalexin found in grape skin, grape products, and peanuts as well as red wine, has been reported to have various biological and pharmacological properties. The purpose of this study was to investigate the anti-obesity effect of resveratrol-amplified grape skin extracts on adipocytes. The anti-obesity effects of grape skin extracts were investigated by measuring proliferation and differentiation in 3T3-L1 cells.

Suppression of oxidative stress by grape seed supplementation in rats.

Polyphenol-rich grape seeds have a beneficial effect on human health. The present study was performed to investigate the effects of grape seeds on antioxidant activities in rats. Male Sprague-Dawley rats were randomly divided into a control diet group (C), a high-fat diet group (HF), a 5% grape seed-supplemented control diet group (G), and a 5% grape seed-supplemented high-fat diet group (HG).

Designing biomaterials for in situ periodontal tissue regeneration.

The regeneration of periodontal tissue poses a significant challenge to biomaterial scientists, tissue engineers and periodontal clinicians. Recent advances in this field have shifted the focus from the attempt to recreate tissue replacements/constructs ex vivo to the development of biofunctionalized biomaterials that incorporate and release regulatory signals in a precise and near-physiological fashion to achieve in situ regeneration. The molecular and physical information coded within the biomaterials define a local biochemical and mechanical niche with complex and dynamic regulation that establishes key interactions with host endogenous cells and, hence, may help to unlock latent regenerative pathways in the body by instructing cell homing and regulating cell proliferation/differentiation.

Low cytotoxicity porous Nd(2)(SiO(4))(3) nanoparticles with near infrared excitation and emission.

Porous Nd(2)(SiO(4))(3) nanoparticles were successfully synthesized by a controlled route. This kind of silicate nanoparticle could be excited by near-infrared (NIR) radiation (808 nm) and triggered a NIR emission (1066 nm) at room temperature. By monitoring the 1066 nm emission, the long-lived luminescent lifetime was determined to be 19.

Fabrication of apatite-type La(9.33)(SiO4)6O2 hollow nanoshells as energy-saving oxidative catalysts.

Apatite-type La(9.33)(SiO(4))(6)O(2) hollow nanoshells were successfully synthesized by a controlled route. These oxide-ion-conducting hollow nanoshells were used to catalyze oxidative coupling of methane, and an enhanced catalytic performance at relatively low temperature was realized.

[Correlation of ornidazole concentration in saliva and serum of healthy volunteers].

Objective: To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.

Methods: Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion.

Hydrothermal microemulsion synthesis of oxidatively stable cobalt nanocrystals encapsulated in surfactant/polymer complex shells.

Air-stable magnetic cobalt nanocrystals have been conveniently prepared via a reverse micellar synthesis, followed by a hydrothermal treatment. The synthesis was carried out by first mixing an aqueous solution containing cobalt chloride and poly(sodium 4-styrenesulfonate) (PSS) with an organic mixture containing cetyltrimethylammonium bromide (CTAB) to form reverse micelles, followed by reducing cobalt ions with sodium borohydride. The resultant nanoparticles were then undergone a hydrothermal treatment at 165 degrees C for 8 h to generate well-dispersed CTAB/PSS-encapsulated cobalt nanocrystals with an average diameter of 3.

Risks faced by donors of right lobe for living donor liver transplantation.

Background: Because of the shortage of deceased donors with livers fit for transplantation, living donor liver transplantation (LDLT) is becoming an attractive alternative. Attention should be paid to the donors, especially to those of the right lobe. In this study, we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.

[Portal vein flow rate used as a early predictor of portal vein thrombosis after periesophagastric devascularization].

Objective: To evaluate the predictive value of portal vein flow rate preoperative for portal vein thrombosis (PVT) after periesophagastric devascularization in hepatitis B cirrhosis-related portal hypertension.

Methods: From January 2007 to July 2008, 45 patients with portal hypertension caused by hepatitis B cirrhosis were performed splenectomy with peri-esophagogastric devascularization in the same medical group in West China Hospital of Sichuan University. The portal vein flow rate and the diameter of portal vein were measured with doppler sonography respectively before and after the operation.

A hierarchical lattice structure and formation mechanism of ZnO nano-tetrapods.

The existence of characteristic longitudinal optical and transverse optical phonons of cubic ZnO in ZnO nano-tetrapods is determined by Raman spectroscopy and first-principles calculations. Stacking sequence change at the boundary of the core and legs is also identified by high-resolution transmission electron microscopy. Based on this experimental and theoretical evidence, we demonstrate that the lattice structure of ZnO nano-tetrapods is hierarchical with a zinc blende core connecting to four wurtzite legs.

Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation.

Background: Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The goal of this study was to study the population pharmacokinetics of remifentanil in the different phases of orthotopic liver transplantation (OLT) and the influence of relevant factors.

Methods: Thirteen adult patients undergoing OLT were enrolled.

[Neonatal septicemia caused by Listeria monocytogenes: report of 6 cases].

Objective: Neonatal listeriosis is a relatively rare but serious disease with a high mortality rate. This study was conducted to analyze the clinical features, treatment, and outcome of 6 cases with Listeria monocytogenes septicemia confirmed by positive blood cultures.

Methods: Totally 12,538 live births delivered in the hospital from January 1, 2004 to June 30, 2006 were investigated.

Glow discharge growth of SnO2 nano-needles from SnH4.

Single crystalline SnO(2) nano-needles with length up to 6-7 microm and diameter less than 300 nm are synthesized on an Au-coating porous silicon substrate from SnH(4) source via a glow discharge process.

Starlike nanostructures of polyoxometalates K3[PMo12O40].nH2O synthesized and assembled by an inverse microemulsion method.

In a nonionic inverse microemulsion system, surfactant (C12-18EO9)/cyclohexane/water, heteropolyanions [PMo12O40]3- react with K+ to form K3[PMo12O40].nH2O nanorods and assemble as three-dimensional starlike nanostructures.