Associations of Sedentary Time and Physical Activity with Metabolic Syndrome among Chinese Adults: Results from the China Health and Nutrition Survey.

Objective: This study aimed to determine the independent and joint associations of sedentary time (ST) and physical activity (PA) with metabolic syndrome (MetS) and its components among Chinese adults.

Methods: The study analyzed data from 4,865 adults aged ≥ 18 years who participated in the 2009 and 2015 China Health and Nutrition Surveys (CHNS). Four types of leisure ST and three types of PA self-reported at baseline were collected.

Generation of transgenic marmosets expressing genetically encoded calcium indicators.

Chronic monitoring of neuronal activity in the living brain with optical imaging techniques became feasible owing to the continued development of genetically encoded calcium indicators (GECIs). Here we report for the first time the successful generation of transgenic marmosets (Callithrix jacchus), an important nonhuman primate model in neurophysiological research, which were engineered to express the green fluorescent protein (GFP)-based family of GECIs, GCaMP, under control of either the CMV or the hSyn promoter. High titer lentiviral vectors were produced, and injected into embryos collected from donor females.

Longitudinal functional magnetic resonance imaging in animal models.

Functional magnetic resonance imaging (fMRI) has had an essential role in furthering our understanding of brain physiology and function. fMRI techniques are nowadays widely applied in neuroscience research, as well as in translational and clinical studies. The use of animal models in fMRI studies has been fundamental in helping elucidate the mechanisms of cerebral blood-flow regulation, and in the exploration of basic neuroscience questions, such as the mechanisms of perception, behavior, and cognition.

Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.

Epigenetic silencing of RASSF (Ras association domain family) genes RASSF1 and RASSF5 (also called NORE1) by CpG hypermethylation is found frequently in many cancers. Although the physiological roles of RASSF1 have been studied in some detail, the exact functions of RASSF5 are not well understood. Here, we show that RASSF5 plays an important role in mediating apoptosis in response to death receptor ligands, TNF-α and TNF-related apoptosis-inducing ligand.

Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor.

Secreted Slit proteins have previously been shown to signal through Roundabout (Robo) receptors to negatively regulate axon guidance and cell migration. During vertebrate development, Slit proteins have also been shown to stimulate branching and elongation of sensory axons and cortical dendrites. In this study, Slit1/Robo2 mRNA and protein expressions were detected in adult rat dorsal root ganglion (DRG) and in cultured DRG neurons.

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cancer has not been studied. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent.

How polluted is the Yangtze river? Water quality downstream from the Three Gorges Dam.

The concentrations of major anions and cations, nitrogen and phosphorus, dissolved and particulate trace elements, and organic pollutants were determined for the middle and lower reaches of the Yangtze River (Changjiang) from below the Three Gorges Dam (TGD) to the mouth at Shanghai in November 2006. The concentration of dissolved inorganic phosphate (DIP) was constant at a low level of 6-8 microgP/L, but the concentration of nitrate (NO(3)(-)) approximately doubled downstream and was closely correlated with K(+). This translated to a daily load of well over 1000 t of dissolved inorganic nitrogen (DIN) at Datong.

A three-dimensional lead(II) coordination polymer: poly[aqua-mu-imidazole-4,5-dicarboxylato-lead(II)].

In the title coordination polymer, [Pb(C5H2N2O4)(H2O)](n), the Pb(II) atom is seven-coordinated by one N atom and five O atoms from four individual imidazole-4,5-dicarboxylate (HIDC2-) groups and one water molecule. It is interesting to note that the HIDC2- group serves as a bridging ligand to link the Pb(II) atoms into a three-dimensional microporous open-framework.

Poly[[bis(pyridin-3-ol)manganese(II)]-di-mu-pyridin-3-olato].

In the title complex, [Mn(C5H4NO)2(C5H5NO)2]n or [Mn(mu-3-PyO)2(3-PyOH)2]n (3-PyO- is the pyridin-3-olate anion and 3-PyOH is pyridin-3-ol), the Mn(II) atom lies on an inversion centre and has octahedral geometry, defined by two N atoms and two deprotonated exocyclic O atoms of symmetry-related pyridin-3-olate ligands [Mn-N = 2.3559 (14) A and Mn-O = 2.1703 (11) A], as well as two N atoms of terminal 3-PyOH ligands [Mn-N = 2.