Publications by authors named "Xiameng Kang"
Article Synopsis
- The polyamine transporter system (PTS) is identified as a promising target for tumor therapy and imaging, with researchers developing a gallium-68 labeled spermine derivative for tumor imaging in mice.
- The new compound, [Ga]Ga-NOTA-Spermine, shows a high radiochemical yield and substantial cellular uptake in A549 cancer cells, peaking at 90 minutes.
- Biodistribution studies reveal significant accumulation in the kidneys and liver, low levels in other tissues, and effective tumor imaging results in mouse models, indicating its potential use as a PET imaging agent for tumors with elevated PTS levels.
