Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway.

As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women's health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable of preventing estrogen-related diseases. Here, we aimed to investigate whether SDG can counteract cyclophosphamide (CTX) induced premature ovarian insufficiency (POI) and further explore its specific molecular mechanism.

The COVID-19 pandemic and residential mobility intentions in the United States: Evidence from Google Trends data.

The COVID-19 pandemic has disrupted people's lives through economic challenges, closure of worksites and schools and increased health risks. These disruptions can trigger new residential needs and preferences, but little research has been done regarding the impact of the COVID-19 pandemic on moving intentions. We theorized how the pandemic could influence intentions of making different types of residential moves.