The Impact and Mechanism of Action of Peptostreptococcus anaerobius on Chemotherapy Resistance in Human Colorectal Cancer.

Peptostreptococcus anaerobius plays an important role in the development of colorectal cancer, and previous studies by our group have demonstrated that Peptostreptococcus anaerobius promotes resistance to 5-Fu chemotherapy in animal models of colorectal cancer. In this study, the effects of Peptostreptococcus anaerobius on chemotherapy resistance in colorectal cancer and its possible mechanism of action were investigated from the clinical point of view. Patients were selected according to exclusion and inclusion criteria and divided into sensitive and chemotherapy groups (n = 20/group).

Deciphering the mechanism of -induced chemoresistance in colorectal cancer: the important roles of MDSC recruitment and EMT activation.

(, ) in intestinal flora of patients with colorectal cancer (CRC) are associated with poor prognosis. Studies have shown that could promote colorectal carcinogenesis and progression, but whether could induce chemoresistance of colorectal cancer has not been clarified. Here, both and experiments showed that specifically colonized the CRC lesion and enhanced chemoresistance of colorectal cancer to oxaliplatin by recruiting myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment.