A New Hypoxia-Related Prognostic Risk Score (HPRS) Model Was Developed to Indicate Prognosis and Response to Immunotherapy for Lung Adenocarcinoma.

Background: Hypoxia is a typical microenvironmental feature of most solid tumors, affecting a variety of physiological processes. We developed a hypoxia-related prognostic risk score (HPRS) model to reveal tumor microenvironment (TME) and predict prognosis of lung adenocarcinoma (LUAD).

Methods: LUAD sample expression data were from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

[A survey on adolescent scoliosis in Guangzhou].

Objective: To investigate the prevalence of adolescent scoliosis in Guangzhou for development of effective prevention and treatment program to the disease.

Methods: From November 2007 to July 2009, 30 142 students between 7 to 20 years old in primary and junior middle schools received physical check-up for detection of scoliosis through physical and radiographic examination.

Results: 211 cases were diagnosed as scoliosis (Cobb angle ≥ 10°), with the prevalence rate as 0.