Publications by authors named "Xiafei Zhao"
Abnormalities of carbohydrate antigen 19 - 9 (CA19-9) are common in patients with type 2 diabetes mellitus (T2DM), and in some patients, CA19-9 returns to normal level after glycemic control. The aim of this study was to investigate the factors associated with CA19-9 levels in patients with T2DM and the associated influences on the degree of reduction of CA19-9 levels after antidiabetic therapy (AT). This study was an observational cross-sectional study.
View Article and Find Full Text PDFCryptotanshinone promotes brown fat activity by AMPK activation to inhibit obesity.
Nutr Res Pract
August 2024
Background/objectives: Activating brown adipose tissue (BAT) and browning of white adipose tissue (WAT) can protect against obesity and obesity-related metabolic conditions. Cryptotanshinone (CT) regulates lipid metabolism and significantly ameliorates insulin resistance. Adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK), a receptor for cellular energy metabolism, is believed to regulate brown fat activity in humans.
View Article and Find Full Text PDFArticle Synopsis
- Distal metastases significantly lower the prognosis for colorectal cancer patients, with around 95% of these cancers being DNA mismatch repair proficient (pMMR).
- Previous research indicates that the microRNA miR-6511b-5p is less expressed in pMMR cases, but its specific role in cancer metastasis remained unclear.
- Experimental studies showed that miR-6511b-5p can inhibit metastasis by reducing the expression of CD44 through direct interaction with BRG1, suggesting it could serve as a potential biomarker and treatment target for metastatic pMMR colorectal cancer.
[Diagnostic accuracy of muscle ultrasound and plasma monocyte chemoattractant protein-1 for ICU-acquired weakness in patients with sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
January 2022
Article Synopsis
- The study investigates how well muscle ultrasound and plasma MCP-1 levels can diagnose ICU-acquired weakness (ICU-AW) in septic patients.
- A total of 99 patients were studied, with results showing that those with ICU-AW were generally younger and had more severe health issues compared to those without ICU-AW.
- The researchers used various measurements and tests, including muscle thickness and plasma MCP-1 concentration, to assess the risk factors and diagnostic accuracy for ICU-AW in these patients.
[Characteristics and control measures of 2019 novel coronavirus Delta variant of concern].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
September 2021
2019 novel coronavirus (2019-nCoV) Delta variant of concern (VOC) is one of the variants of 2019-nCoV, which has the characteristics of strong transmission, high pathogenicity, and rapid progression. 2019-nCoV Delta VOC has caused a global pandemic. Understanding the characteristics of 2019-nCoV Delta VOC and implementing targeted control measures are important aspects of controlling the pandemic.
View Article and Find Full Text PDF[Risk factors and their predictive value for intensive care unit acquired weakness in patients with sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
June 2021
Objective: To explore the risk factors of intensive care unit acquired weakness (ICUAW) in patients with sepsis, and to evaluate the predictive value of each risk factor for ICUAW.
Methods: A case control study was conducted, 60 septic patients admitted to the intensive care unit (ICU) of Henan Provincial People's Hospital from October 20, 2020 to February 20, 2021 were enrolled. The patients were divided into two groups: sepsis ICUAW group and sepsis non-ICUAW group.