A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood-brain barrier.

Drug-resistant epilepsy (DRE) is a chronic condition derived from spontaneous changes and regulatory effects in the epileptic brain. As demethylation factors, ten-eleven translocation (TET) family members have become a focus in recent studies of neurological disorders. Here, we quantified and localized TET1, TET2 and 5-hydroxymethylcytosine (5-hmC) in the temporal lobe cortex of DRE patients (n = 27) and traumatic brain hemorrhage controls (n = 10) by immunochemical staining.

Clinicopathologic and neuroradiologic studies of papillary glioneuronal tumors.

Background: Papillary glioneuronal tumor (PGNT) is a rare, recently described distinct low-grade brain neoplasm. This study was performed to characterize the clinicopathologic and neuroradiologic features of PGNTs.

Methods: We reviewed the medical records of 16 patients with PGNT who underwent surgery, including 11 males and five females (median age 27 years).

[Effect of embedding thread at Shenshu (BL 23) on clinical pain of postmenopausal osteoporosis].

Objective: To explore the effect of embedding thread at Shenshu (BL 23) on clinical pain of postmenopausal osteoporosis.

Methods: Fifty-six cases were randomly divided into an embedding thread group, an embedding thread plus Leli group and a Leli group. The pain of the patient before treatment, 3 months and 6 months after treatment were assessed.