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Publications by authors named "Xia-Zhen Xu"

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Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy.
Jiacheng Lin Limin Yin Xia-Zhen Xu He-Chen Sun Zhi-Hua Huang Xue-Yun Ni Xu Lin

PLoS Pathog

January 2022

Article Synopsis
  • The hepatitis B virus (HBV) core protein plays a crucial role in the viral life cycle, and compounds like Bay41-4109 can alter this by disrupting HBV capsid assembly.
  • Bay41-4109 induces the formation of non-capsid polymers, whose removal from cells is dependent on the E3 ubiquitin ligase STUB1, which helps transport these polymers for degradation.
  • Enhancing STUB1 levels boosts the effectiveness of Bay41-4109 in reducing HBV production and cccDNA formation, indicating potential for targeted HBV treatment strategies.
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