Synopsis of recent research by authors named "Xia-Xia Fan"
- Xia-Xia Fan's research focuses on the cytotoxic effects of various compounds on cancer cells, particularly in relation to mitochondrial function and apoptosis mechanisms.
- Key findings reveal that T-2 toxin disrupts mitochondrial integrity in human gastric epithelial cells, while synthetic analogs like DN3 and DS2 showcase potent antitumor activities by directly targeting mitochondria and inducing apoptosis through reactive oxygen species generation.
- The studies highlight the potential of novel synthetic diterpenoids as effective therapeutic agents for gastric and esophageal cancers, demonstrating improved activity compared to traditional compounds like oridonin.
