The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis.

Parkinson's disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered important resources for the discovery of new drugs due to their distinctive structures and diverse activities.

Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1.

Aims: To screen coral-derived compounds with neuroprotective activity and clarify the potential mechanism of lead compounds.

Methods: The lead compounds with neuroprotective effects were screened by H O and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP )-induced cell damage models in SH-SY5Y cells. CCK8 and LDH assays were used to detect cell viability.

Acautalides A-C, Neuroprotective Diels-Alder Adducts from Solid-State Cultivated sp. H-JQSF.

The solid-state cultivation of sp. H-JQSF isolated from produces acautalides A-C (-) as skeletally unprecedented Diels-Alder adducts of a 14-membered macrodiolide to an octadeca-9,11,13-trienoic acid. The acautalide structures, along with the intramolecular transesterifications of 1-acylglycerols, were elucidated by mass spectrometry, nuclear magnetic resonance, chemical transformation, and single-crystal X-ray diffraction.

Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease.

Background: Senescent astrocytes have been implicated in the aging brain and neurodegenerative disorders, including Parkinson's disease (PD). Astragaloside IV (AS-IV) is an antioxidant derivative from a traditional Chinese herbal medicine Astragalus membraneaceus Bunge and exerts anti-inflammatory and longevity effects and neuroprotective activities. However, its effect on astrocyte senescence in PD remains to be defined.