Self-Assembled Chiral Phosphorescent Microflowers from Au Nanoclusters with Dual-Mode pH Sensing and Information Encryption.

The self-assembly of chiral metal nanoclusters into supramolecular chiral aggregates is of interest for developing advanced materials. Herein, we manipulated the self-assembly of Au nanoclusters modified by l-/d-cysteine (l-/d-AuNCs) into ordered microstructures featuring enhanced phosphorescence and optical activities. The formation of these aggregates was driven by synergistic effect of coordination and electrostatic interactions assisted by Cd/H.

Amendment of straw biochar increased molecular diversity and enhanced preservation of plant derived organic matter in extracted fractions of a rice paddy.

While biochar enhanced carbon sequestration and stability of soil organic matter (SOM), changes in organic molecular composition in biochar-amended soils had been poorly addressed. In this study, molecular composition changes of a paddy topsoil 2 years following amendments at 10 t ha OC equivalent with untreated (CS), manured (CM) and charred (CB) maize straw were compared to no amendment (CK). Topsoil SOM was sequentially extracted with ultrapure water (UWE), solvent (TSE), base hydrolysis (BHY) and CuO oxidation (CUO) and molecular compounds in these extracted fractions were detected quantitatively by GC/MS.

The Comparison of Sarcopenia Diagnostic Criteria using AWGS 2019 with the Other Five Criteria in West China.

Introduction: The aim of this study was to investigate the prevalence and associated factors of sarcopenia defined by different criteria in community-dwelling adults of west China using the baseline data of West-China Health and Aging Trend (WCHAT) study.

Methods: Adults aged 50 years or older in communities of Yunnan, Guizhou, Sichuan, and Xinjiang provinces were enrolled in this study. We applied 6 -diagnostic criteria (AWGS 2019, AWGS 2014, EWGSOP1, -EWGSOP2, IWGS, and FNIH) to define sarcopenia.

Fluorescent nanocomposites based on gold nanoclusters for metal ion detection and white light emitting diodes.

Gold nanoclusters (AuNCs) are among the most promising organic-inorganic hybrid luminescent materials for various applications. The current development of AuNCs majorly focuses on controlling their luminescence properties. Herein, we report a new strategy to facilely construct two different nanocomposites featuring enhanced photoluminescence based on mercaptopropionic acid-protected AuNCs (MPA-AuNCs).

The association of sleep quality and sleep duration with nutritional status in older adults: Findings from the WCHAT study.

Objective: To identify the associations between sleep quality, sleep duration and nutritional status in older adults.

Methods: Data from a total of 6792 community-dwellings adults aged 50 and over from the baseline of the West China Health and Aging Trend (WCHAT) study were analyzed. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).

Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.

The efficacy of cancer immunotherapy is dictated by CD8 T cell infiltration and the nature of the tumor microenvironment (TME). By inflaming the TME to favor CD8 T cell immunity, radiation is now widely considered as a neoadjuvant for immunomodulation. Here, we observed that local irradiation enhances the infiltration of intratumoral eosinophils, and depletion of eosinophil dampens CD8 T cell infiltration and diminishes the anti-tumor effectiveness of radiation.

Multiple Physical Symptoms of Community-Dwelling Older People in Western China: Prevalence and Its Association with Frailty.

Introduction: Physical symptoms and frailty are common in older adults. A previous study has reported that multiple somatic symptoms are associated with frailty. In this study, we aimed to describe the picture of physical symptoms in older adults in western China and examine the relationship of multiple physical symptoms and frailty, as well as the sex difference of this relationship.

Boosting the Output Performance of the Triboelectric Nanogenerator through the Nonlinear Oscillator.

The rapid development of the internet of things and autonomous vehicles requires plenty of sensors to monitor environmental conditions continuously. Hence, the high energy density and reliable power supply are demanded. The nonlinear oscillator has been widely utilized to enhance the output performance of piezoelectric and electromagnetic energy harvesters, which can operate in high-energy orbits under proper excitation frequencies.

3D Printable, Modified Trephine Designs for Consistent Anterior Lamellar Keratectomy Wounds in Rabbits.

Purpose: Our goal is to develop a low-cost tool that can be used to create consistent, partial-thickness defects in rabbit and other large animals with minimal surgical training and that can facilitate pre-clinical testing of lamellar and in situ-forming biosynthetic matrix materials for corneal repair.

Materials & Methods: In this study, three modified trephines were designed to create deep corneal wound defects with consistent depth in large animals. The modified trephines incorporated either 3D-printed parts made from photopolymerizable resins, or custom-cut commercially available Teflon sheets.

Preparation and characterization of apoacynum venetum cellulose nanofibers reinforced chitosan-based composite hydrogels.

Addition of nanomaterials into polymer matrix is a promising avenue to reinforce the mechanical properties of composites. In this work, chitosan-based hydrogels reinforced by cellulose nanofibers (CNFs) have been prepared by chitosan as matrix. The effect of CNFs (1vt%, 1.

A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.

Background: Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling, remains largely unknown.

Results: In this study, we describe a novel protein SMO-193a.

Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration.

The failure of adult CNS neurons to survive and regenerate their axons after injury or in neurodegenerative disease remains a major target for basic and clinical neuroscience. Recent data demonstrated in the adult mouse that exogenous expression of Sry-related high-mobility-box 11 (Sox11) promotes optic nerve regeneration after optic nerve injury but exacerbates the death of a subset of retinal ganglion cells (RGCs), α-RGCs. During development, Sox11 is required for RGC differentiation from retinal progenitor cells (RPCs), and we found that mutation of a single residue to prevent SUMOylation at lysine 91 (K91) increased Sox11 nuclear localization and RGC differentiation Here, we explored whether this Sox11 manipulation similarly has stronger effects on RGC survival and optic nerve regeneration.

CaCoMnO: A Promising Perovskite Solid Solution for Solar Thermochemical Energy Storage.

The redox cycle of doped CaMnO has emerged as an attractive way for cost-effective thermochemical energy storage (TCES) at high temperatures in concentrating solar power. The role of dopants is mainly to improve the thermal stability of CaMnO at high temperatures and the overall TCES density of the material. Herein, Co-doped CaMnO (CaCoMnO, = 0-0.

An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.

The metabolic role of micropeptides generated from untranslated regions remains unclear. Here we describe MP31, a micropeptide encoded by the upstream open reading frame (uORF) of phosphatase and tensin homolog (PTEN) acting as a "circuit breaker" that limits lactate-pyruvate conversion in mitochondria by competing with mitochondrial lactate dehydrogenase (mLDH) for nicotinamide adenine dinucleotide (NAD). Knocking out the MP31 homolog in mice enhanced global lactate metabolism, manifesting as accelerated oxidative phosphorylation (OXPHOS) and increased lactate consumption and production.

Risk of catheter-related bloodstream infection associated with midline catheters compared with peripherally inserted central catheters: A meta-analysis.

Background: Both midline catheters (MCs) and peripherally inserted central catheters (PICCs) can cause catheter-related bloodstream infection (CRBSI), but the prevalence associated with each is not clear.

Objective: To compare the risk of CRBSI between MCs and PICCs with a meta-analysis.

Methods: The Web of Science Core Collection, PubMed, Scopus, Embase, The Cochrane Library and ProQuest were searched.

Achieving Ultrahigh Output Energy Density of Triboelectric Nanogenerators in High-Pressure Gas Environment.

Through years of development, the triboelectric nanogenerator (TENG) has been demonstrated as a burgeoning efficient energy harvester. Plenty of efforts have been devoted to further improving the electric output performance through material/surface optimization, ion implantation or the external electric circuit. However, all these methods cannot break through the fundamental limitation brought by the inevitable electrical breakdown effect, and thus the output energy density is restricted.

MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.

Loss of retinal ganglion cells (RGCs) in optic neuropathies results in permanent partial or complete blindness. Myocyte enhancer factor 2 (MEF2) transcription factors have been shown to play a pivotal role in neuronal systems, and in particular MEF2A knockout was shown to enhance RGC survival after optic nerve crush injury. Here we expanded these prior data to study bi-allelic, tri-allelic and heterozygous allele deletion.

Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.

Objective: ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases.

COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden.

The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged ⩾70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the structure and organisation of care, and interventions within the complex public-health system.

Laser-induced nano-bismuth decorated CdS-graphene hybrid for plasmon-enhanced photoelectrochemical analysis.

Direct-laser-writing of a plasmon-enhanced photoelectrode is successfully demonstrated via the in situ and straightforward formation of a laser-induced Bi-CdS-graphene nanohybrid, which shows a significantly amplified and stable photocurrent response and, thus, further provides a highly sensitive PEC sensing platform.

Comorbid depressive and anxiety symptoms and frailty among older adults: Findings from the West China health and aging trend study.

Background: Depression and anxiety are two common mental disorders in older people. Studies have reported that depression is strongly associate with frailty, but few studies focus on anxiety disorder and comorbid two mental disorders. In this study, we aimed to identify associations between comorbid depressive and anxiety symptoms with frailty in older adults.