FAM3C Regulates Glioma Cell Proliferation, Invasion, Apoptosis, and Epithelial Mesenchymal Transition via the Notch Pathway.

Background: Previous studies have implicated the involvement of FAM3C in cancerous development and progression. Herein, we aimed to further investigate the oncological mechanism of FAM3C, specifically in glioma.

Methods: We utilized open-source bioinformatics tools and platforms to analyze the transcriptional expression levels, prognosis, and correlation with clinical variables of FAM3C in gliomas, and subsequently, to hypothesize its potential molecular functions and possibly associated signaling pathways.

Toward Fully Controllable Monomers Sequence: Binary Organocatalyzed Polymerization from Epoxide/Aziridine/Cyclic Anhydride Monomer Mixture.

The sequence of monomers within a polymer chain plays a pivotal role in determining the physicochemical properties of the polymer. In the copolymerization of two or more monomers, the arrangement of monomers within the resulting polymer is primarily dictated by the intrinsic reactivity of the monomers. Precisely controlling the monomer sequence in copolymerization, particularly through the manipulation of catalysts, is a subject of intense interest and poses significant challenges.

Surface Modification of PEEKs with Cyclic Peptides to Support Endothelialization and Antithrombogenicity.

Synthetic polymers are often utilized in the creation of vascular devices, and need to possess specific qualities to prevent thrombosis. Traditional strategies for this include surface modification of vascular devices through covalent attachment of substrates such as heparin, antiplatelet agents, thrombolytic agents, or hydrophilic polymers. One promising prosthetic material is polyether ether ketone (PEEK), which is utilized in various FDA-approved medical devices, including vascular and endovascular prostheses.

Extracellular Vesicles Derived from Glioma Stem Cells Affect Glycometabolic Reprogramming of Glioma Cells Through the miR-10b-5p/PTEN/PI3K/Akt Pathway.

Objective: Glioma is one of the most prevalently diagnosed types of primary malignant brain tumors. Glioma stem cells (GSCs) are crucial in glioma recurrence. This study aims to elucidate the mechanism by which extracellular vehicles (EVs) derived from GSCs modulate glycometabolic reprogramming in glioma.

Multidimensional Control of Repeating Unit/Sequence/Topology for One-Step Synthesis of Block Polymers from Monomer Mixtures.

Synchronously and thoroughly adjusting the chemical structure difference between two blocks of the diblock copolymer is very useful for designing materials but difficult to achieve via self-switchable alternating copolymerization. Here, we report self-switchable alternating copolymerization from a mixture of two different cyclic anhydrides, epoxides, and oxetanes, where a simple alkali metal carboxylate catalyst switches between ring-opening alternating copolymerization (ROCOP) of cyclic anhydrides/epoxides and ROCOP of cyclic anhydrides/oxetanes, resulting in the formation of a perfect block tetrapolymer. By investigating the reactivity ratio of these comonomers, a reactivity gradient was established, enabling the precise synthesis of block copolymers with synchronous adjustment of each unit's chemical structure/sequence/topology.

One-step synthesis of sequence-controlled multiblock polymers with up to 11 segments from monomer mixture.

Switchable polymerization holds considerable potential for the synthesis of highly sequence-controlled multiblock. To date, this method has been limited to three-component systems, which enables the straightforward synthesis of multiblock polymers with less than five blocks. Herein, we report a self-switchable polymerization enabled by simple alkali metal carboxylate catalysts that directly polymerize six-component mixtures into multiblock polymers consisting of up to 11 blocks.

Mechanical Property and Structure of Polypropylene/Aluminum Alloy Hybrid Prepared via Ultrasound-Assisted Hot-Pressing Technology.

The polypropylene/aluminum alloy hybrid was prepared via an ultrasonic-assisted hot-pressing technology (UAHPT). The mechanical property and structure of the UAHPT processed polypropylene/aluminum alloy hybrid were explored by the tensile shear test, scanning electron microscopy (SEM), and atomic force microscopy (AFM), respectively. Prior to obtaining the UAHPT processed hybrid, the microporous structures were prepared by the anodic oxidation in a phosphoric acid solution in which the polypropylene (PP) melt flowed into and formed the micro mechanical interlocking structure at the interface of polypropylene/aluminum alloy.

Influence of Diameter on the Templated Crystallization of Polyethylene/Carbon Material Fiber Composites under Intense Shear Flow.

In this study, carbon fibers (CFs) and carbon nanofibers (CNFs) were introduced into polyethylene (PE) and intensive shear flow was imposed on the melt during the melt second flow caused by gas penetrating the melt during the gas-assisted injection molding (GAIM). The effect of fiber diameter on crystalline morphologies of obtained composites was deeply studied. The results revealed the fact that no matter whether CFs or CNFs were introduced into the PE matrix or not, the orientation degree of PE lamellae would increase during the melt second flow.

Varying-coefficient semiparametric model averaging prediction.

Forecasting and predictive inference are fundamental data analysis tasks. Most studies employ parametric approaches making strong assumptions about the data generating process. On the other hand, while nonparametric models are applied, it is sometimes found in situations involving low signal to noise ratios or large numbers of covariates that their performance is unsatisfactory.

Influence of HMW tail chains on the structural evolution of HDPE induced by second melt penetration.

It is widely accepted that the role of the high molecular weight (HMW) component is cooperative in shear-induced crystallization, owing to entanglements among long chains. However, this paper demonstrates that the HMW component has a novel effect on structural evolution during the process of multi-melt multi-injection molding (MIM), organized as follows. First, the appropriate HDPE system with an incremental concentration of HMW tails was established.

Strong shear-driven large scale formation of hybrid shish-kebab in carbon nanofiber reinforced polyethylene composites during the melt second flow.

The formation of a hybrid shish-kebab (HSK) structure with different degrees of lamellar orientations was first observed in the solution crystallization of polyethylene (PE) in the presence of carbon nanofibers (CNFs). In this study, PE crystal lamellae were periodically decorated on the surface of CNFs and were aligned approximately perpendicular to the long axes of the CNFs, forming aligned hybrid shish-kebab nanostructures. More importantly, the fascinating structure was directly formed in all regions of the injection molded bars of HDPE/CNF composites, via a gas-assisted injection molding (GAIM), instead of the shell-core structure.

Formation of various crystalline structures in a polypropylene/polycarbonate in situ microfibrillar blend during the melt second flow.

A strong shear flow was imposed on the melt of polycarbonate (PC) microfibrils with β-nucleation agent reinforced isotactic polypropylene (iPP) during the melt second flow process, i.e. gas-assisted injection molding (GAIM).

Low-dimensional confounder adjustment and high-dimensional penalized estimation for survival analysis.

High-throughput profiling is now common in biomedical research. In this paper we consider the layout of an etiology study composed of a failure time response, and gene expression measurements. In current practice, a widely adopted approach is to select genes according to a preliminary marginal screening and a follow-up penalized regression for model building.