Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis.

Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.

Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment.

Background: Recent studies have highlighted the distinct ratio of PD-1 + Treg/PD-1 + CD8 for prognosis prediction. However, it remains unclear about the association of this ratio and tertiary lymphoid structures (TLS) with prognosis and response to neoadjuvant or conversion therapy in advanced gastric cancer.

Methods: Firstly, fresh postoperative samples from 68 gastric cancer patients in Renji Hospital were collected.

New Contributions on Species Diversity of Genus and s.l. in China.

Southwest China is extremely rich in fungal resources, and a large number of new taxa have been discovered in recent years. In the present study, we examined 26 specimens of the genera and sensu lato, most of which were obtained in Yunnan Province. Through ITS-nrLSU- phylogenetic analysis, combined with morphological studies and geographic analyses, five new species were described, viz.

A Space Telescope Scheduling Approach Combining Observation Priority Coding with Problem Decomposition Strategies.

With the increasing number of space debris, the demand for telescopes to observe space debris is also constantly increasing. The telescope observation scheduling problem requires algorithms to schedule telescopes to maximize observation value within the visible time constraints of space debris, especially when dealing with large-scale problems. This paper proposes a practical heuristic algorithm to solve the telescope observation of space debris scheduling problem.

Identification of two distinct clusters in membranous lupus nephritis patients: recognition of a high-risk profile based on unsupervised analysis.

Background And Hypothesis: Membranous lupus nephritis (MLN) traditionally includes class V (alone) and may be associated with other classes (III or IV). The clinical, therapeutic and prognosis relevance of the classification remains controversial.

Methods: A retrospective cohort of 412 MLN patients from the First Affiliated Hospital of Sun-Yat Sen University was followed for a median of 65.

sRNA STnc3020 contributes to the virulence of Salmonella Typhimurium may via modulating the gene expression of prgJ of T3SS needle complex.

As important post-transcriptional regulators of gene expression, sRNAs play important modulatory roles in the environmental adaptation and virulence of bacteria. To investigate the regulatory role of sRNA STnc3020 in the virulence of Salmonella Typhimurium (S. typhimurium).

Shikonin hastens diabetic wound healing by inhibiting M1 macrophage polarisation through the MAPK signaling pathway.

Diabetes is an endocrine disorder characterized by abnormally elevated blood glucose levels. Diabetic patients often exhibit impaired wound healing capabilities, particularly in the lower limbs, which is one of the numerous complications of diabetes. This is a significant factor leading to recurrent inflammation, disability, and even amputation.

The disability-adjusted life years (DALYs), prevalence and incidence of scabies, 1990-2021: A systematic analysis from the Global Burden of Disease Study 2021.

Background: Current literature lacks a recent global analysis of scabies. This study aims to analyze the burden and epidemiological characteristics of scabies using data from the Global Burden of Disease (GBD) 2021 study.

Methodology/principal Findings: The analysis assessed disability-adjusted life years (DALYs), prevalence, and incidence of scabies from 1990 to 2021, stratified by geographic location, socio demographic index (SDI), gender, and age.

How Physical Exercise Reduces Problematic Mobile Phone Use in Adolescents: The Roles of Expression Suppression, Depression, Anxiety, and Resilience.

Background: Problematic mobile phone use has become a pressing concern among adolescents due to its widespread prevalence and associated health risks. Physical exercise has been suggested as a potential intervention, but the psychological mechanisms underlying its effects remain unclear. This study explores how physical exercise impacts problematic mobile phone use through expression suppression, emotional problems (depression and anxiety), and resilience, offering actionable insights for intervention strategies.

Liver Function Biomarkers and Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank.

Background: As the primary organ of metabolism and detoxification, the liver may contribute to the pathogenesis of lung cancer. We aimed to illuminate the intricate link between liver function biomarkers and lung cancer risk, as well as delineate the role of smoking behavior within this association.

Methods: We investigated the associations of seven liver function biomarkers levels (alkaline phosphatase [ALP], alanine transaminase [ALT], total bilirubin [TBIL], albumin [ALB], gamma-glutamyltransferase [GGT], aspartate transaminase [AST], and total protein [TP]) with lung cancer risk across the UK Biobank (N = 337 499) through restricted cubic splines and Cox proportional hazards models.

Scalable fabrication of biohybrid magnetic MOF-based micromotors for toxin enrichment.

Contemporary industrial production and human activity release numerous toxins into our environment. Metal-organic frameworks (MOFs) are potential candidates for addressing these toxins due to their ultrahigh surface area, tailored pore size, and responsiveness to stimuli. With the rise of micro/nanomotor, imparting active motion to MOFs becomes crucial for efficiently performing tasks in challenging locations.

Traumatic renal artery thrombosis: a case report and literature review.

Traumatic Renal Artery Thrombosis (TRAT) is an uncommon condition characterized by a low clinical incidence and a lack of specific symptoms, making it highly susceptible to being overlooked or misdiagnosed. This retrospective analysis aims to review the diagnostic and therapeutic approaches applied to a TRAT patient who received successful treatment in the Emergency Medicine Department of the First People's Hospital of Kunshan. The objective is to enhance clinicians' comprehension of TRAT, promote early diagnosis and intervention, and ultimately improve patient outcomes.

Unveiling the intricate interplay: Exploring biological bridges between renal ischemia-reperfusion injury and T cell-mediated immune rejection in kidney transplantation.

Unlabelled: Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well known, the mechanism remains unclear. We investigated essential genes and biological processes involved in interactions between IRI and TCMR.

Methods: Renal IRI and TCMR datasets were obtained from the Gene Expression Omnibus database.

Plasmon Enhanced IR Spectroelectrochemistry.

Plasmon-enhanced infrared (IR) techniques have garnered significant interest for their ability to achieve greatly more sensitive IR detection than conventional surface enhanced IR techniques. However, the difficulty in electrically connecting antennas has limited their application in IR spectroelectrochemistry, a crucial field for catalysis, analysis, and energy storage. Recent technical advancements have enabled the successful application of electrochemical potentials to antennas, making plasmon-enhanced IR spectroelectrochemistry feasible.

The impact of meteorological conditions on cardiovascular and cerebrovascular diseases in different microclimatic zones of low-latitude mountainous areas.

Introduction: Epidemiological evidence suggests cerebrovascular disease (CVD) incidence is correlated to meteorological conditions. However, research on the primary meteorological factors influencing the incidence of CVD and their influence thresholds in low-latitude mountainous regions remains insufficient. We aimed to investigate the association between meteorological conditions and CVD occurrence in Guizhou province.

Circulating tumor DNA detection improves relapse prediction in epithelial ovarian cancer.

Background: Epithelial ovarian cancer (EOC) is a lethal form of gynecological malignancy. Some EOC patients experience relapse after standard primary debulking surgery (PDS) and adjuvant chemotherapy (ACT). Identifying molecular residual disease (MRD) by circulating tumor DNA (ctDNA) detection can timely signal the potential for relapse.

Identification of AXL as a novel positive regulator of lipid raft in gastric cancer.

Lipid rafts are highly heterogeneous and dynamic microdomains involved in molecule trafficking and signaling transduction. This study investigates the role of lipid rafts in gastric cancer and their key regulators. Analyzing FFPE samples from 111 gastric cancer patients, we found that high lipid raft levels predict poor prognosis.

Insights into the flavor contribution, mechanisms of action, and future trends of coagulase-negative staphylococci in fermented meat products: A review.

During fermentation, meat is pre-treated and cured to cultivate a diverse microflora, resulting in fermented meat products with distinctive flavors. Coagulase-negative staphylococcus holds a crucial role in all fermented meat products, contributing to the breakdown of proteins, carbohydrates, and fats, and the creation of flavor compounds. Fermentation technology has important research value and significance in fermented meat products.

Research progress on the mechanism of hyperuricemic nephropathy based on multi-omics technique: A review.

Hyperuricemic nephropathy is a metabolic disease in which renal uric acid deposition and excretion are impaired due to elevated levels of uric acid in the blood, leading to impaired renal tubule function and chronic renal disease. Hyperuricemic nephropathy is one of the important complications of hyperuricemia, which seriously affects the quality of life and prognosis of patients. The pathogenesis of hyperuricemic nephropathy involves a variety of factors, including: amino acid metabolism disorder, energy metabolism abnormality, increased nucleotide metabolism, lipid metabolism disorder and bile acid metabolism imbalance, REDOX process disorder, cell cycle and apoptosis imbalance, signal transduction and inflammatory response enhancement, and intestinal flora imbalance.

regulates the proliferation and differentiation of neural stem/progenitor cells.

Background: MicroRNAs (miRNAs) have emerged as an essential regulator of the cell fate commitment of neural stem/progenitor cells (NPCs), although the impacts of certain miRNAs on NPCs remain vague. The aim of this study is to investigate the regulatory effects of on the cell fate commitment of NPCs.

Methods: We investigated the impact of on the proliferation and differentiation capacities of primary NPCs by manipulating the expression of using specific mimics and inhibitors.

Regulation of PILS genes by bZIP transcription factor TGA7 in tomato plant growth.

Auxin plays a pivotal role in plant growth regulation. The PIN-FORMED (PIN) proteins facilitate long-distance polar auxin transport, whereas the recently identified PIN-LIKES (PILS) proteins regulate intracellular auxin homeostasis. However, the auxin transport mechanisms in horticultural crops remain largely unexplored.

Clinical surveillance of split renal function in kidney transplant recipients using Tc-diethylenetriamine-pentaacetic acid (DTPA) dynamic renal scintigraphy: preliminary findings and novel insights.

Background: En bloc kidney transplantation (EBKT) involves transplantation of two kidneys, the aorta, and inferior vena cava from a deceased pediatric donor into an adult recipient. Recent articles have shown that EBKT is associated with excellent long-term allograft performance and patient survival. Developmental differences exist between the two transplanted kidneys after EBKT, and it is crucial to assess split renal function.

Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.

Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid tissues instead of returning to secondary lymph organs after the antigen presentation. These cells can provide rapid on-site immune protection as well as long-term tissue damage. It is reported that TRM cells from small intestine and colon exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional and functional heterogeneity.

The genomic landscape of short tandem repeats in cattle.

Short tandem repeats (STRs) are abundant and have high mutation rates across cattle genomes; however, comprehensive exploration of cattle STRs is needed. Here, we constructed a comprehensive map of 467 553 polymorphic STRs (pSTRs) constructed from 423 cattle genomes representing 59 breeds worldwide. We observed that pSTRs in coding sequences and 5'UTRs (Untranslated Regions) were under strong selective constraints and exhibited a relatively low level of diversity.

Associations of sociodemographic and smoking characteristics with intention to quit among Chinese adults aged 20-69 years who smoke: Findings from nationwide China Health Literacy Survey during 2018-19.

Objective: To identify factors influencing the intention to quit (ItQ) among Chinese who smoke, focusing on 10th Revision of the International Classification of Diseases (ICD-10) Nicotine dependence. Additionally, to estimate the number of individuals with ItQ, supporting optimal allocation of cessation resources.

Methods: This study used data from the 2018 China Health Literacy Survey, a nationally representative cross-sectional study with 20,288 participants who smoke currently aged 20-69 years.