Publications by authors named "Xia Tian"

Purpose: Variant interpretation, guided by American College of Medical Genetics and Genomics guidelines, can inform clinical decision-making. However, interpretations may change over time for a variety of reasons. Periodic reanalysis of previous variant interpretations is important to ensure that reported genetic findings remain accurate according to current knowledge.

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Electrocatalytic organic oxidation coupled with hydrogen (H) production emerges as a profitable solution to simultaneously reduce overall energy consumption of H production and synthetic high-value chemicals. Noble metal catalysts are highly efficient electrocatalysts in oxidation reactions, but they deactivate easily weakening the benefit in actual production. Herein, we report a universal asymmetric pulse potential strategy to achieve long-term stable operation of noble metals for various alcohol oxidation reactions and noble metal catalysts.

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The metastasis or recurrence of rhabdomyosarcoma (RMS) is the primary cause of tumour-related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall survival rate of 20-30%. The lack of specific drug-targeted therapy and chemotherapy resistance are the main reasons for treatment failure.

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A practical and efficient -diboration of propargyl alcohols was accomplished using sodium hydride (NaH) as a base in ,-dimethylformamide at room temperature. The mild reaction conditions demonstrate general applicability, facilitating the successful conversion of both terminal and internal propargyl alcohols with diverse structures and functional groups into highly functionalized alkenediboronates [4-borylated 1,2-oxaborol-2(5)-oles]. The resulting products, which incorporate two boron groups, can be selectively activated and subjected to stepwise transformations, thereby providing an effective platform for synthesizing a wide range of structurally diverse trisubstituted alkenes.

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Article Synopsis
  • EVA1B is found to be significantly up-regulated in esophageal squamous cell carcinoma (ESCC) tissues, linking it to advanced cancer stages and increased myeloid-derived suppressor cells (MDSCs).
  • Silencing EVA1B leads to reduced proliferation and tumor growth in ESCC cells and mouse models, promoting apoptosis and disrupting cell cycle progression.
  • The study suggests that targeting EVA1B could hinder both ESCC progression and MDSC activity, highlighting its potential as a therapeutic strategy for ESCC patients.
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High mobility group box 1 (HMGB1) has the capability of activating the immune response and taking part in macrophage polarization. Despite this, there is significant scope for exploration into how HMGB1 regulates macrophage polarization phenotype and influences intestinal epithelial barrier function. Investigating the role of HMGB1 in the creation of neutrophil extracellular traps (NETs) and the mechanism of its impact on macrophages could provide novel insights into intervening in intestinal inflammation and barrier damage.

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The post-treatment based on spin-coating (SC) organic amine salts is commonly used for surface modification of perovskite films to eliminate defects. However, there is still a lack of systematic study and a unified understanding of the functions and mechanisms of different organic amine salts. The SC method is also not conducive to the industrialization of solar cells.

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Acne vulgaris is a prevalent chronic skin condition characterized by the presence of comedones, papules, and pustules on the face, neck, and chest. To simulate the inflammation of acne vulgaris, this protocol details an approach to establish a compound acne rodent model by inducing acne inflammation in rat ears using oleic acid and Cutibacterium acnes (C. acnes).

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Purpose: White matter (WM) abnormalities are associated with various central nervous system (CNS) disorders, and the optic nerve provides a unique opportunity to study WM pathology. Large animal models offer a more suitable platform for preclinical testing of novel therapeutic strategies for optic neuropathy due to their similarities to humans in size and relevant anatomy. Transcriptomic analyses of optic nerve tissue are essential for understanding the underlying pathological mechanisms.

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Background: The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.

Methods: From 1 January 2015 to 31 December 2021, all consecutive HT recipients in our institute were included and analysed for the occurrence of AKI within the first seven postoperative days. Patients transplanted between 2015 and 2019 comprised the derivation cohort, and those transplanted between 2020 and 2021 formed the validation cohort.

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The "Developmental Origins of Health and Disease, DOHaD" theory suggests that adverse factors in early life can lead to the occurrence of chronic diseases in adulthood. In recent years, it has been discovered that maternal factors, intrauterine development environment and environmental exposure during pregnancy can mediate the changes of early egg/embryo development, promote the occurrence of reproductive disorders such as polycystic ovary syndrome, diminished ovarian reserve, and endometriosis, and induce intergenerational genetic effects. This article has reviewed the progress of research on maternal factors which may affect the pathogenesis of reproductive disorders, and expounds its mechanism from the perspectives of epigenetic mechanisms such as DNA methylation, histone modification and non-coding small RNA (miRNA) modification, with an aim to provide insights for studying the occurrence of adult reproductive disorders in early life and before pregnancy.

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The aim of the study was to analyze and discuss the value of preoperative systemic immune inflammation index (SII) and prognostic nutritional index (PNI) in predicting the prognosis of patients with renal cell carcinoma (RCC) after operation, and to establish a nomogram prediction model for patients with RCC after operation based on SII and PNI. From January 2014 to December 2018, 210 patients with RCC who underwent surgical treatment at the Xuzhou Central Hospital were selected as the research object. The receiver operating characteristic curve (ROC) was used to determine the optimal cut-off value for preoperative SII, PNI, LMR, PLR, NLR and the patients were divided into groups according to the optimal cutoff values.

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Porous hydrogel microspheres with temperature-sensitive, magnetic and fluorescent properties have great potential for drug delivery. In this study, porous hydrogel microspheres with excellent temperature-sensitive, magnetic and fluorescent properties were prepared through droplet microfluidics and photoinitiated radical polymerization, which were characterized scanning electron microscopy (SEM), vibrating sample magnetometry (VSM), fluorescence spectroscopy, ultraviolet spectrophotometry, and other techniques. The volumetric phase-transition temperature of porous hydrogel microspheres was in the range of 40-45 °C, and the volume swelling ratio reached 5.

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Severe tissue defects present formidable challenges to human health, persisting as major contributors to mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects, poses substantial hurdles to existing tissue regeneration strategies. However, the emergence of nanobiotechnology has opened a new direction in immunomodulatory nanomedicine, providing encouraging prospects for tissue regeneration and restoration.

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Article Synopsis
  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition, and the study investigates how the weight-adjusted waist index (WWI) correlates with mortality rates in affected individuals, compared to the traditional BMI metric.
  • The research used data from adults with MASLD between 1999-2018, analyzing their waist circumference and body weight to assess WWI and its impact on both all-cause and cardiovascular disease mortality.
  • Results showed that higher WWI is linked to an increased risk of mortality even after adjusting for BMI, suggesting that WWI is a more accurate predictor of health risks in MASLD patients than BMI alone.
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Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid (CSF) flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of G-protein signaling 22 (RGS22) results in severe congenital hydrocephalus in both mice and rats.

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