Publications by authors named "Xia Tang"

Sleep behavior is regulated by diverse mechanisms including genetics, neuromodulation and environmental signals. However, it remains completely unknown regarding the roles of epitranscriptomics in regulating sleep behavior. In the present study, we showed that the deficiency of RNA mA methyltransferase Mettl3 in excitatory neurons specifically induces microglia activation, neuroinflammation and neuronal loss in thalamus of mice.

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Background: Colorectal cancer (CRC) is a prevalent malignancy worldwide, associated with significant morbidity and mortality. Cyclin-dependent kinase 1 (CDK1) plays a crucial role in cell cycle regulation and has been implicated in various cancers. This study aimed to evaluate the prognostic value of CDK1 in CRC and to identify traditional Chinese medicines (TCM) that can target CDK1 as potential treatments for CRC.

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Article Synopsis
  • The study focuses on the role of the PtoASMT gene in melatonin biosynthesis in poplar trees, which affects their growth and stress responses.
  • PtoASMT is highly expressed in various poplar tissues, particularly in petioles, and influences melatonin levels, contributing to drought tolerance and resistance to certain fungi.
  • Overexpressing PtoASMT improves drought resistance and reduces reactive oxygen species compared to wild-type plants, while knockout variants show increased sensitivity.
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During a survey of microfungi associated with forest plants, four specimens related to were collected from decaying wood in Guizhou, Hainan and Yunnan Provinces, China. species have sexual and asexual forms. They are commonly found as saprophytes on decaying wood and have been reported as disease-causing pathogens in humans as well.

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The composition of waste-activated sludge (WAS) is complex, containing a large amount of harmful substances, which pose a threat to the environment and human health. The reduction and resource utilization of sludge has become a development demand in sludge treatment and disposal. Based on the technical bottlenecks in the practical application of direct anaerobic digestion technology, this study adopted two different thermal and thermal-alkali hydrolysis technologies to pretreat sludge.

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species are a group of helicosporous hyphomycetes with the potential to produce secondary metabolites. During our investigation of helicosporous fungi, six collections were isolated from both terrestrial and freshwater habitats in Guizhou Province, China. Based on multigene phylogenetic analysis (ITS, LSU, and ), coupled with morphological data, three new species, viz.

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The immune response plays a crucial role in the functionality of oncolytic viruses. In this study, Albendazole, an antihelminthic drug known to modulate the immune checkpoint PD-L1, was combined with the oncolytic virus M1 (OVM1) to treat mice with either prostate cancer (RM-1) or glioma (GL261) tumors. This combination therapy enhanced anti-tumor effects in immunocompetent mice, but not in immunodeficient ones, without increasing OVM1 replication.

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Carbon source is a key factor determining the denitrifying effectiveness and efficiency in wastewater treatment plants (WWTPs). Whereas, the relationships between diverse and distinct denitrifying communities and their favorable carbon sources in full-scale WWTPs were not well-understood. This study performed a systematic analysis of the relationships between the denitrifying community and carbon sources by using 15 organic compounds from four categories and activated sludge from 8 full-scale WWTPs.

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  • The study explored how carbonization temperature (300-700 °C) and time (0.5-1.5 hours) affect the characteristics of products made from carbonized municipal sludge.
  • It found that increasing temperature and time led to more complete carbonization, altering the material’s structure, reducing organic content, and changing its physical properties significantly.
  • Key outcomes included a reduction in conductivity, decreased natural water absorption, and a lower higher calorific value, while heavy metals became more concentrated but remained largely unavailable.
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During our investigation of saprophytic fungi in Guizhou and Hainan provinces, China, three hyphomycetes were collected from terrestrial and freshwater habitats. Based on morphological characteristics and phylogenetic analyses of combined ITS, LSU, 1-α, and 2 sequence data, two new species are introduced: and . Additionally, one known species, , previously unreported from , is newly reported.

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The increased use of disinfection since the pandemic has led to increased effective chlorine concentration in municipal wastewater. Whereas, the specific impacts of active chlorine on nitrogen and phosphorus removal, the mediating communities, and the related metabolic activities in wastewater treatment plants (WWTPs) lack systematic investigation. We systematically analyzed the influences of chlorine disinfection on nitrogen and phosphorus removal activities using activated sludge from five full-scale WWTPs.

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Artificial oasis is an important geographical unit that is formed by the combination of natural disturbances and human interventions in a fragile ecosystem of arid regions. Therefore, there are important theoretical and practical significance to estimate long term artificial oasis changes and its driving mechanism. We took Hexi Corridor in northwest of China as a case study, based on multi-types of data included documentary reconstruction records, historical archives data and published articles to quantitative analyze the relationship between artificial oasis evolution and a set of natural and human factors over the past two millennia (0-1990 AD).

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Tetraplosphaeriaceae (Pleosporales, Ascomycota) is a family with many saprobes recorded from various hosts, especially bamboo and grasses. During a taxonomic investigation of microfungi in tropical and subtropical forest regions of Guizhou, Hainan and Yunnan provinces, China, several plant samples were collected and examined for fungi. Four newly discovered species are described based on morphology and evolutionary relationships with their allies inferred from phylogenetic analyses derived from a combined dataset of LSU, ITS, SSU, and DNA sequence data.

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  • Drought makes it hard for plants to grow and produce food, especially with climate change happening.
  • Scientists studied a gene called PtoMYB99 in poplar trees to see how it affects their ability to handle drought.
  • They found that when this gene is overactive, it changes how the trees react to water stress, making them less capable of coping with drought.
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Ebstein's anomaly, a rare congenital heart disease, is distinguished by the failure of embryological delamination of the tricuspid valve leaflets from the underlying primitive right ventricle myocardium. Gaining insight into the genetic basis of Ebstein's anomaly allows a more precise definition of its pathogenesis. In this study, two distinct cohorts from the Chinese Han population were included: a case-control cohort consisting of 82 unrelated cases and 125 controls without cardiac phenotypes and a trio cohort comprising 36 parent-offspring trios.

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Ebstein's anomaly is a rare congenital heart disease characterized by tricuspid valve downward displacement and is associated with additional cardiac phenotypes such as left ventricle non-compaction. The genetic basis of Ebstein's anomaly has yet to be fully elucidated, although several genes (e.g.

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is a species-rich order of fungi that includes endophytes, saprobes, and pathogens associated with forest plants and crops. They may also occur as parasites or secondary invaders of plant tissues injured or infected by other organisms or inhabit living animal and human tissues, as well as soil. Meanwhile, some severe pathogens wipe out large-scale cultivations of profitable crops, timber monocultures, and forests.

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  • Multifocal hepatocellular carcinoma (MF-HCC) represents over 40% of hepatocellular carcinomas and tends to have a worse prognosis compared to single tumors, making it crucial to understand its molecular evolution for better treatment strategies.
  • The research involved whole-exome sequencing of multiple tumor samples from patients to categorize MF-HCC into subtypes and analyze their genetic features, including timing and mechanisms of metastasis.
  • The findings revealed three distinct subtypes of MF-HCC, significant changes in mutational signatures, and early metastatic seeding, highlighting common ancestral clones in preneoplastic lesions, which deepen our understanding of tumor evolution and potential targeted therapies.
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In this study, we extracted and identified the active components of the Asian citrus psyllid, Diaphorina citri sex pheromones to provide a basis for further development of sex attractants. Under laboratory conditions, mating activity in D. citri started 3 d after emergence, which peaked at 6-7 d, and mating activity had no obvious peak during the observed period 7:00-21:00 h.

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  • A novel nanochannel hydrogel sensor is developed that improves upon traditional filler-based wearable hydrogels by utilizing a unique electrospun fiber textile structure and double network hydrogel properties.
  • The new design features a tightly interconnected TiCT MXene distribution in the hydrogel, enhancing its electrical conductivity and sensitivity due to increased micromovement.
  • This TiCT MXene nanochannel hydrogel demonstrates excellent mechanical properties, self-adhesion, antifreezing abilities, and effectively detects various human motions and physiological signals with high stability.
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Adsorption showed advantages in removing phosphorus (P) at low concentrations. Desirable adsorbents should have sufficiently high adsorption capacity and selectivity. In this study, a Ca-La layered double hydroxide (LDH) was synthesized for the first time by using a simple hydrothermal coprecipitation method for phosphate removal from wastewater.

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Objective To investigate the anti-DNA damage role of Sigma factor E (SigE) and its regulation mechanism of DNA damage repair in Mycobacterium smegmatis(MS). Methods The SigE gene of Mycobacterium smegmatis was cloned into plasmid pMV261 to construct recombinant plasmid pMV261(+)-SigE, and the inserted gene was verified by sequencing. The recombinant plasmid was electrically transformed into Mycobacterium smegmatis to construct SigE over-expression strain, and the expression of SigE was detected by Western blot analysis.

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Background: The D68 (EV-D68) epidemic has increased knowledge of the virus as a pathogen capable of causing serious respiratory and neurological illnesses. It has been shown that long noncoding RNAs (lncRNAs) regulate viral replication and infection via multiple mechanisms or signaling pathways. However, the precise function of lncRNAs in EV-D68 infection remains unknown.

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There remain challenges in accurately identifying constitutional or germline copy number variants (gCNVs) based on whole-exome sequencing data that have implications for genetic diagnosis for 'rare undiagnosed disease' in the clinical setting. Although multiple algorithms have been proposed, a systematic comparison of these algorithms for calling gCNVs and analyzing inherited pattern have yet to be fully conducted. Therefore, we empirically compared seven exome-based algorithms, including XHMM, CLAMMS, CODEX2, ExomeDepth, DECoN, CN.

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