miR-363-5p protects from neuropathic pain in chronic constriction injury (CCI) rat models and regulates Schwann cell injury via negatively modulating SERPING1.

Objectives: Due to the complex and unclear pathogenesis of neuropathic pain, there is a lack of effective therapeutic strategy. miR-363-5p was considered of great potential in mediating the development of neuropathic pain, which has not been confirmed with direct evidence. This study evaluated the role of miR-363-5p in neuropathic pain with animal and cell models, aiming to reveal the potential of miR-363-5p in target therapy of neuropathic pain.

microRNA-125b-5p alleviated CCI-induced neuropathic pain and modulated neuroinflammation via targeting SOX11.

Background: Increasing evidence demonstrated the involvement of microRNAs (miRNAs) in the onset and development of neuropathic pain (NP). Exploring the molecular mechanism underlying NP and identifying key molecules could provide potential targets for the therapy of NP. The function and mechanism of miR-125b-5p in regulating NP have been studied, aiming to find a potential therapeutic target for NP.

Wind and structural loads data measured on parabolic trough solar collectors at an operational power plant.

Wind loading is a primary contributor to structural design costs of concentrating solar-thermal power collectors, such as heliostats and parabolic troughs. These structures must resist the mechanical forces generated by turbulent wind, while the reflector surfaces must maintain optimal optical performance. Studying wind-driven loads at a full-scale, operational concentrating solar-thermal power plant provides insights into the wind impact on the solar collector field beyond the capabilities of wind tunnel tests or state-of-the-art simulations.

Association between morphologic features of intracranial distal arteries and brain atrophy indexes in cerebral small vessel disease: a voxel-based morphometry study.

Background: Brain atrophy represents a final common pathway for pathological processes in patients with cerebral small vessel disease (CSVD) and is now recognized as a strong independent predictor of clinical status and progression. The mechanism underlying brain atrophy in patients with CSVD is not yet fully comprehended. This study aims to investigate the association of morphologic features of intracranial distal arteries (A2, M2, P2 and more distal) with different brain structures [gray matter volume (GMV), white matter volume (WMV), and cerebrospinal fluid volume (CSFV)].

Monitoring Wheat Lodging at Various Growth Stages.

Lodging is one of the primary factors that reduce wheat yield; therefore, rapid and accurate monitoring of wheat lodging helps to provide data support for crop loss and damage response and the subsequent settlement of agricultural insurance claims. In this study, we aimed to address two problems: (1) calculating the wheat lodging area. Through comparative experiments, the SegFormer-B1 model can achieve a better segmentation effect of wheat lodging plots with a higher prediction rate and a stronger generalization ability.

MiR-204-5p Alleviates Neuropathic Pain by Targeting BRD4 in a Rat Chronic Constrictive Injury Model.

Purpose: The pathogenesis of neuropathic pain is complex, and previous studies have found that microRNAs are important regulators of neuropathic pain and are associated with the progression of neuropathic pain. This study aims to explore the level and role of miR-204-5p in the chronic constrictive injury (CCI) model of rats.

Patients And Methods: The CCI rat model was constructed to evaluate paw withdrawal threshold (PWT), paw withdrawal latency (PWL), the expressions of miR-204-5p, and the contents of inflammatory factors in the model.

Case report: Meningitis and intracranial aneurysm caused by mixed infection of oral microflora dominated by anaerobes.

Introduction: Meningitis caused by oral anaerobic bacteria is rare, especially when complicated with an infected intracranial aneurysm. This paper has described an extremely rare case of bacterial meningitis caused by a mixed infection of oral microflora dominated by anaerobes, which developed cerebral infarcts, brain abscess, intracranial aneurysm, and severe hydrocephalus during treatment.

Case Report: We describe a 65-year-old male patient who was presented with fever and headache as the initial symptoms and then developed left ophthalmoplegia, right hemiplegia, and disturbance of consciousness.

Application of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide.

Background: Endotoxemia is related to worse clinical outcomes in acute liver failure (ALF), but its management remains unsatisfactory. In this study, we aimed to assess whether the application of bone marrow mesenchymal stem cells (BMSCs) could eliminate endotoxemia and protect rats against ALF induced by thioacetamide (TAA).

Methods: BMSCs were isolated from rats and identified by the specific morphology, differentiation potential, and surface markers.

Deep multi-kernel auto-encoder network for clustering brain functional connectivity data.

In this study, we propose a deep-learning network model called the deep multi-kernel auto-encoder clustering network (DMACN) for clustering functional connectivity data for brain diseases. This model is an end-to-end clustering algorithm that can learn potentially advanced features and cluster disease categories. Unlike other auto-encoders, DMACN has an added self-expression layer and standard back-propagation is used to learn the features that are beneficial for clustering brain functional connectivity data.

Bone marrow mesenchymal stem cells differentiate into intestinal epithelioid cells through the ERK1/2 pathway.

Background/aims: Previous studies have found that the injection of rat bone marrow mesenchymal stem cells (rBMSCs) in a mouse model of acute hepatic failure significantly relieves intestinal damage and endotoxemia. However, the mechanism of this process remains unknown. This study demonstrated the differentiation of rBMSCs into enterocyte-like cells and possible molecular mechanisms for this with the aim of finding a new treatment for intestinal epithelial injury and endotoxemia during liver failure.

A target screening method for detection of organic pollutants in fruits and vegetables by atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry combined with informatics platform.

This study employed an atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry (APGC-QTOF-MS) combined with UNIFI scientific platform to establish a scientific screening library for the screening of 104 organic contaminants in fruits and vegetables. The developed approach shortened the analysis time in comparison with the traditional gas chromatography mass spectrometer (GC-MS/MS). All compounds can be separated by using the three-dimensional (3D) acquisition mode supported by UNIFI platform.

Observational Evidence for Desert Amplification Using Multiple Satellite Datasets.

Desert amplification identified in recent studies has large uncertainties due to data paucity over remote deserts. Here we present observational evidence using multiple satellite-derived datasets that desert amplification is a real large-scale pattern of warming mode in near surface and low-tropospheric temperatures. Trend analyses of three long-term temperature products consistently confirm that near-surface warming is generally strongest over the driest climate regions and this spatial pattern of warming maximizes near the surface, gradually decays with height, and disappears in the upper troposphere.

Prognostic significance of tumor-associated macrophages density in gastric cancer: a systemic review and meta-analysis.

Introduction: Tumor-associated macrophages (TAM) play a dual role in the development of gastric cancer (GC). This study aims to analyze the prognostic value of TAM density in GC patients.

Evidence Acquisition: We conducted a meta-analysis of 11 studies (N.

Observed Thermal Impacts of Wind Farms Over Northern Illinois.

This paper assesses impacts of three wind farms in northern Illinois using land surface temperature (LST) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) instruments onboard the Terra and Aqua satellites for the period 2003-2013. Changes in LST between two periods (before and after construction of the wind turbines) and between wind farm pixels and nearby non-wind-farm pixels are quantified. An areal mean increase in LST by 0.

Distribution of poly- and perfluoroalkyl substances in matched samples from pregnant women and carbon chain length related maternal transfer.

Although levels of poly- and perfluoroalkyl substances (PFASs) in human maternal and neonatal blood have been widely reported in the literature, relationship of maternal-fetal transmission of PFASs with carbon chain length is presently not well understood. In this study, 11 PFASs were analyzed in matched samples, including not only maternal blood (MB, n = 31) and cord blood (CB, n = 30), but also placenta (n = 29) and amniotic fluid (AF, n = 29). Except for perfluorohexanoic acid (PFHxA), the detection frequencies of PFASs were similar among placenta, MB, and CB (>80% for 8 PFASs, nondetectable for 2 PFASs).

Fluorescent sensing ochratoxin A with single fluorophore-labeled aptamer.

We explored a fluorescent strategy for sensing ochratoxin A (OTA) by using a single fluorophore-labeled aptamer for detection of OTA. This method relied on the change of the fluorescence intensity of the labeled dye induced by the specific binding of the fluorescent aptamer to OTA. Different fluorescein labeling sites of aptamers were screened, including the internal thymine bases, 3'-end, and 5'-end of the aptamer, and the effect of the labeling on the aptamer affinity was investigated.

Screening interaction between ochratoxin A and aptamers by fluorescence anisotropy approach.

By taking advantage of the intrinsic fluorescence of ochratoxin A (OTA), we present a fluorescence anisotropy approach for rapid analysis of the interactions between OTA and aptamers. The specific binding of OTA with a 36-mer aptamer can induce increased fluorescence anisotropy (FA) of OTA as the result of the freedom restriction of OTA and the increase of molecular volume, and the maximum FA change is about 0.160.

Perfluorinated compounds in human blood, water, edible freshwater fish, and seafood in China: daily intake and regional differences in human exposures.

Despite the growing public interest in perfluorinated compounds (PFCs), very few studies have reported the sources and pathways of human exposure to these compounds in China. In this study, concentrations of 10 PFCs were measured in human blood, water (tap water and surface water), freshwater fish, and seafood samples collected from China. On the basis of the data, we calculated daily intakes of PFCs, regional differences in human exposures, and potential risks associated with ingestion of PFCs from diet, drinking water, and indoor dust for the Chinese population.