G protein-coupled receptors (GPCRs) are sensors for the G protein complex to sense changes in environmental factors and molecular switches for G protein complex signal transduction. In this study, the homologous gene of GPCR-like proteins was identified from maize and named as ZmCOLD1. Subcellular analysis showed that the ZmCOLD1 protein is localized to the cell membrane and endoplasmic reticulum.
View Article and Find Full Text PDFDetermining priority areas for territorial ecological restoration in the arid region of Northwest China based on the holistic protection and systematic governance is an important measure to build solid national ecological security barrier and promote the construction of territorial ecological civilization. Taking Zhangye City, a typical arid area city in Northwest China, as an example, we constructed the research framework of "ecological network-ecological sensitivities-ecological degradation" from two aspects of internal defects and external threats of ecological networks by using circuit theory and assessment methods of ecological service function importance, ecological sensitivity, and ecological degradation. We then identified the priority areas of territorial ecological restoration in northwest arid region and put forward the restoration strategies.
View Article and Find Full Text PDFWetlands play a key role in maintaining ecological balance and climate regulation. However, due to the complex and variable spectral characteristics of wetlands, there are no publicly available global 30-meter time-series wetland dynamic datasets at present. In this study, we present novel global 30 m annual wetland maps (GWL_FCS30D) using time-series Landsat imagery on the Google Earth Engine platform, covering the period of 2000-2022 and containing eight wetland subcategories.
View Article and Find Full Text PDFBackground: Geriatric diseases (e.g., chronic diseases and geriatric syndromes) may result in impaired physical performance and a decline in the quality of life.
View Article and Find Full Text PDFSci Total Environ
January 2024
Desertification is a major manifestation of land degradation in China. The monitoring and assessment of land desertification in China and the analysis of its driving mechanisms are crucial to the realization of the aspiration of "net zero land degradation" proposed by the United Nations Convention to Combat Desertification (UNCCD). An improved Mediterranean Desertification and Land Use (MEDALUS) model was applied to assess the multiyear spatial distribution of land desertification sensitivity across China in 2010, 2015, and 2020.
View Article and Find Full Text PDFNumerous validation efforts have been conducted over the last decade to assess the accuracy of global leaf area index (LAI) products. However, such efforts continue to face obstacles due to the lack of sufficient high-quality field measurements. In this study, a fine-resolution LAI dataset consisting of 80 reference maps was generated during 2003-2017.
View Article and Find Full Text PDFHepatocellular carcinoma is a highly malignant and lethal tumor. In addition to surgery, immunotherapy is currently a more effective treatment for hepatocellular carcinoma. The tumor immune microenvironment (TIME) largely determines the efficacy of cancer immunotherapy.
View Article and Find Full Text PDFThe carbon catabolite repressor 4-negative on TATA (CCR4-NOT) complex, abbreviated CNOT, has deadenylation and 3'-5' exonuclease activity, mediates deadenylation in the degradation of RNA, initiates the exonuclease degradation pathway, and participates in tumor gene regulation. CNOT proteins comprise a family of global transcriptional regulators that are evolutionarily conserved in eukaryotic cells. Several subunit types of the CNOT complex have been discovered; however, little is known about the role of different subunits in tumorigenesis and development.
View Article and Find Full Text PDFPancreatic cancer is characterized by the absence of early specific clinical symptoms, accompanied with rapid metastasis and invasion. It is one of the most prevalent types of cancer and more importantly, one of the most common types of malignant cancer with the highest mortality rate of all cancer types. The heparanase (HPA)/syndecan-1 (SDC1) axis has been reported to promote tumor growth, invasion, metastasis and angiogenesis in a variety of cancer types; however, studies into the role and mechanism of the HPA/SDC1 axis in pancreatic cancer are limited.
View Article and Find Full Text PDFRecently, the impacts of microRNAs (miRNAs) have been identified in epilepsy (EP), this study was designed to assess the role of miR-183 in hippocampal neuron injury in EP. Rat EP models were established by injected with lithium-pilocarpine. The pathological observation of rats' hippocampus sections was conducted.
View Article and Find Full Text PDFIntroduction: Extrahepatic biliary non-Hodgkin's lymphoma (EBNHL) is rare, with a prevalence of 0.6% of malignant biliary tumors. Primary biliary non-Hodgkin's lymphoma accounts for 0.
View Article and Find Full Text PDFBackground: Although several studies have assessed the effect of Tai Chi in management of chronic obstructive pulmonary disease (COPD), these studies have a wide sample variation and convey inconclusive results. This study aims to determine if a 3-month Tai Chi program improves lung function, exercise capacity, and health related quality of life (HRQoL) in people with COPD.
Methods: A randomised controlled, single blind trial was undertaken.
The novel reductive graphene oxide-based magnetic molecularly imprinted poly(ethylene-co-vinyl alcohol) polymers (rGO@m-MIPs) were successfully synthesized as adsorbents for six kinds of polychlorinated biphenyls (PCBs) in fish samples. rGO@m-MIPs was prepared by surface molecular imprinting technique. Besides, Fe3 O4 nanoparticles (NPs) were employed as magnetic supporters, and rGO@Fe3 O4 was in situ synthesis.
View Article and Find Full Text PDFAtomic steps, a defect common to all crystal surfaces, can play an important role in many physical and chemical processes. However, attempts to predict surface dynamics under nonequilibrium conditions are usually frustrated by poor knowledge of the atomic processes of surface motion arising from mass transport from/to surface steps. Using low-energy electron microscopy that spatially and temporally resolves oxide film growth during the oxidation of NiAl(100) we demonstrate that surface steps are impermeable to oxide film growth.
View Article and Find Full Text PDFNovel multi-walled carbon nanotube modified dummy-template molecularly imprinted microspheres (MWCNTs@DMMIPs) were successfully synthesized as adsorbents for six kinds of polychlorinated biphenyls (PCBs). MWCNTs@DMMIPs were prepared by a surface molecular imprinting technique. Core-shell Fe3 O4 @SiO2 nanoparticles were employed as magnetic support.
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