Publications by authors named "Xi-yun Zhang"
Background: Hepatoblastoma (HB) is the most common liver malignancy in childhood with poor prognosis and lack of effective therapeutic targets. Single-cell transcriptome sequencing technology has been widely used in the study of malignant tumors, which can understand the tumor microenvironment and tumor heterogeneity.
Materials And Methods: Two children with HB and a healthy child were selected as the research subjects.
Article Synopsis
- Combination therapy is currently the standard treatment for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), but response rates are often low, especially in patients resistant to chemotherapy.
- Researchers evaluated a new method called quadratic phenotypic optimization platform (QPOP), which can predict effective drug combinations using limited tumor samples from RR-NHL patients.
- In a study involving 71 patients, QPOP-guided treatments showed improved outcomes and fewer cases of disease progression compared to traditional chemotherapy, providing a strong basis for future clinical trials on this approach.
Long non-coding RNAs (lncRNAs) are closely associated with tumorigenesis of various malignancies, including glioma. However, the roles of most lncRNAs in glioma remain undiscovered. The present study for the first time explored the roles of NFIA-AS2 in glioma.
View Article and Find Full Text PDFBackground: Multiple myeloma is an incurable hematological malignancy characterized by a heterogeneous genetic and epigenetic landscape. Although a number of genetic aberrations associated with myeloma pathogenesis, progression and prognosis have been well characterized, the role of many epigenetic aberrations in multiple myeloma remain elusive. G9a, a histone methyltransferase, has been found to promote disease progression, proliferation and metastasis via diverse mechanisms in several cancers.
View Article and Find Full Text PDF[Association of metabolic syndrome and colorectal cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
December 2011
Objective: To evaluate the association between metabolic syndrome and colorectal cancer.
Methods: A multicenter case-control study was conducted. A total of 1506 cases of colorectal cancer (936 males and 570 females), whose clinical data were complete and aged from 30 to 75, were collected in the Third, First and Second People's Hospital of Jingdezhen between 2000 and 2009.