Publications by authors named "Xi-xue Chen"
Article Synopsis
- Pemphigus vulgaris (PV) is an autoimmune condition characterized by blistering of skin and mucous membranes, primarily caused by autoantibodies against desmoglein (Dsg) 3, which disrupt the adhesion between skin cells.
- A study involving 20 PV patients tested for anti-Dsg3 and anti-Dsg1 autoantibodies using ELISA methods showed significant correlations between autoantibody levels and disease activity scores over time.
- The results indicated that Dsg3 and Dsg1 ELISA values effectively reflect disease activity, demonstrating changes in parallel with flare-ups and remissions, proving to be more reliable than indirect immunofluorescence (IIF) testing.
Background: Paraneoplastic pemphigus (PNP) is an autoimmune-related acquired bullous disease. Delayed diagnosis and treatment of this clinically rare disease often result in poor prognosis.
Methods: Between January 1999 and December 2009, 22 patients with confirmed PNP who underwent surgical resection of underlying tumors were enrolled in this study.
Objectives: To investigate the clinical and pathological subtypes of Castleman's disease (CD) and their relationship with complications.
Methods: The clinical complications of 53 patients with CD and the relationship of these complications with clinical and pathological subtypes were analyzed retrospectively.
Results: Among 53 CD patients, 32 (60.
Research in the field of genetic skin disease has grown rapidly over the past two decades. Even though the fundamental molecular pathways are still not fully understood, there have prominent advances in our understanding of the underlying mechanisms involved in the pathogenesis of genodermatosis. Dermatologists in China contributed to this field in recent years.
View Article and Find Full Text PDF