Formulation development and evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology.

In the present study, a gastric retention floating system for Brucea javanica oil, composed of alginate and carrageenan, was prepared using ionotropic gelation. Parameters for floatability, drug load, encapsulation efficiency, bead morphology, in vitro release, and in vivo gastric retention were evaluated. The optimized formulation via Box-Behnken design consisted of 1.

Budd-Chiari syndrome in China: A 30-year retrospective study on survival from a single center.

Aim: To investigate 30-year treatment outcomes associated with Budd-Chiari syndrome (BCS) at a tertiary hospital in China.

Methods: A total of 256 patients diagnosed with primary BCS at our tertiary hospital between November 1983 and September 2013 were followed and retrospectively studied. Cumulative survival rates and cumulative mortality rates of major causes were calculated by Kaplan-Meier analysis, and the independent predictors of survival were identified using a Cox regression model.

[Preparation and formulation investigation of gastric retention calcium alginate microspheres containing Brucea javanica oil].

Objective: To investigate the preparation technologies of gastric retention calcium alginate microsphere containing Brucea javanica oil, and to evaluate its formulations.

Methods: The formulations of gastric retention calcium alginate microspheres were optimized with G/M ration and concentration of sodium alginate,use level of iron calcium solution and pore-forming agent, cross-link time and pH value of cross-link solution, which had shown a great effect on microspheres morphology, drug release behavior, drug loaded and encapsulation efficiency.

Results: Brucea javanica oil alginate microspheres looked spherical, homogeneous and well distributive.

[Contrast of curative effect and complications between peripheral venous thrombolysis and catheter-direct thrombolysis for acute deep venous thrombosis in lower limbs].

Objective: To evaluate the effects of catheter-direct thrombolysis in acute deep venous thrombosis (DVT).

Methods: A total of 86 cases were divided into 2 groups of peripheral venous thrombolysis (group A, n = 33) and catheter-direct thrombolysis (group B, n = 53). The curative effect of two groups was compared by swelling rate and vascular potency.

[Acute superior mesenteric ischemia: a contrast study on short-and mid-term result between stent implantation and pharmaceutical thrombolysis].

Objective: To compare the short-term and medium-term result of stent implantation with pharmaceutical thrombolysis in patients with acute superior mesenteric artery occlusion.

Methods: From January, 2004 to December, 2008, thirty-five patients diagnosed acute superior mesenteric ischemia, 12 patients treated with stent implantation (interventional therapy group) and 23 patients with pharmaceutical thrombolysis (thrombolytic therapy group). Interventional therapy group treated with balloon dilatation and stent implantation assisted with anticoagulation, antiplatelet and vascular dilation agents.

[Experience in the management of acute superior mesenteric artery ischemia].

Objective: To study the management of acute superior mesenteric artery (SMA) ischemia and to improve its prognosis.

Method: The clinical data of 37 patients treated from January 1996 to August 2007 was retrospectively reviewed.

Results: Of the cases, 19 (51.

[Prevention and treatment of biliary complications following orthotopic liver transplantation].

Objective: To study the prevention and treatment of biliary complications after orthotopic liver transplantation.

Methods: Clinical data of 183 recipients who had received liver transplantation between May 1995 and December 2006 were retrospectively analyzed.

Results: Biliary complications occurred in 15 patients (15/183, 8.