Publications by authors named "Xi-le Zhang"
Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020.
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- Ischemic stroke is a significant health issue globally, and this study explores the neuroprotective effects of Astragaloside IV (AS-IV), a key compound from Astragali Radix traditionally used for stroke treatment.* -
- In experiments with male Sprague-Dawley rats, AS-IV demonstrated improvements in neurological function, reduced brain injury size, and increased SIRT1 protein levels compared to control groups.* -
- The addition of EX527, an inhibitor of SIRT1, negated AS-IV's benefits, leading to worse neurological outcomes and increased brain damage, highlighting SIRT1's crucial role in AS-IV's protective effects.*
Ginseng has been used for the treatment of aging and memory impairment for thousands of years. Several studies have found that ginsenoside Rg1, as one of the main active components of ginseng, could potentially improve cognitive function in several different animal models. A preclinical systematic review to evaluate the efficacy and mechanisms of ginsenoside Rg1 for ameliorating cognitive impairments in Alzheimer's disease is reported here.
View Article and Find Full Text PDFExtracts or active components from Acorus gramineus Aiton (EAAGA) have been clinically used for cognition impairment more than hundreds of years and are still used in modern times in China and elsewhere worldwide. Previous studies reported that EAAGA improves cognition impairment in animal models. Here, we conducted a preclinical systematic review to assess the current evidence of EAAGA for cognition impairment.
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- - Ischemia stroke is a major cause of death and disability, and Sanhua Decoction (SHD), a traditional Chinese herbal treatment, has been used for its prevention and treatment for thousands of years.
- - In a study with male Sprague-Dawley rats, researchers tested the effects of SHD on cerebral ischemia/reperfusion (CIR) injury by administering SHD over different time points and assessing neurological function and cell proliferation.
- - Results showed that SHD significantly improved neurological deficits and increased neural stem cell activity while reducing phosphorylated tau levels, suggesting its potential neuroprotective benefits in stroke recovery.
Alzheimer's disease (AD), the most common cause of dementia, is highly prevalent worldwide with no modifying therapy. Behavioral and psychological symptoms of dementia (BPSD) occur in most patients with AD, and depression is one of the most common AD-related BPSD. Kaixinsan (KXS) is an ancient Chinese herbal prescription widely used to treat dementia and forgetfulness.
View Article and Find Full Text PDF[Three-dimensional low-dose CT volume reconstruction based on non-local weights optimization and GPU acceleration].
Nan Fang Yi Ke Da Xue Xue Bao
December 2011
Concerns have been raised over x-ray radiation dose associated with repeated computed tomography (CT) scans for tumor surveillance and radiotherapy planning. In this paper, we present a low-dose CT image reconstruction method for improving low-dose CT image quality. The method proposed exploited rich redundancy information from previous normal-dose scan image for optimizing the non-local weights construction in the original non-local means (NLM)-based low-dose image reconstruction.
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