Publications by authors named "Xi-bei Jia"
Background: Chronic kidney disease (CKD) is usually considered an immune inflammatory disease. Interaction between platelets and monocytes is associated with immune inflammation. Cross-talk between platelets and monocytes is reflected by formation monocyte-platelet aggregates (MPAs).
View Article and Find Full Text PDFElevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome.
Clin Appl Thromb Hemost
July 2022
Article Synopsis
- Podoplanin (PDPN) interacts with the CLEC-2 receptor on platelets, promoting platelet aggregation and increasing the risk of venous thrombosis, especially in inflammatory conditions.
- A study involving 35 nephrotic syndrome patients and 27 healthy volunteers found that PDPN levels were significantly higher in patients, correlating with various markers of hypercoagulability.
- PDPN demonstrated good predictive value for hypercoagulability in nephrotic syndrome with an area under the curve (AUC) of 0.886, indicating that higher PDPN levels (>5.88 ng/ml) significantly increase the risk of thrombosis.
Objective: This study was performed to investigate the possible nephroprotective effects of losartan in a rat model of experimental IgA nephropathy (IgAN).
Methods: Thirty male Sprague–Dawley rats were randomly divided into three groups. The rats in the model group were treated with bovine serum albumin (oral gavage), lipopolysaccharide (tail vein injection), and carbon tetrachloride (subcutaneous injection); rats in the losartan group received treatments similar to those of the model group, and were orally gavaged with losartan; and rats in the control group received phosphate-buffered saline alone (both orally and intravenously).
Current evidence supports the use of bone marrow-derived mesenchymal stem cells (MSCs) for a diverse range of clinical applications, and many studies have shown that MSCs have renal-protective effects, but the mechanism is not well understood. Therefore, in this study, we aim to further identify whether MSCs can attenuate renal fibrosis by decreasing tubulointerstitial injury in a unilateral ureteral obstruction (UUO) model. In this study, we cultured MSCs and then transplanted them into a UUO model through the tail vein.
View Article and Find Full Text PDFChronic kidney disease (CKD) and peripheral arterial disease (PAD) share common risk factors. We assessed renal function and the prevalence of CKD in patients with PAD and investigated the characteristics of the risk factors for CKD in this population. Renal function of 421 patients with PAD was evaluated.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the levels of soluble thrombomodulin (TM) in patients with chronic kidney disease (CKD) stages 3 to 5 to understand its relationship with disease severity.
- A total of 67 CKD patients and 19 healthy volunteers were tested, finding significantly elevated TM levels in CKD patients compared to controls, particularly in the more severe CKD stages.
- The results suggest that higher soluble TM concentrations correlate with greater disease severity and may indicate processes related to endothelial cell damage and inflammation in CKD.
Article Synopsis
- * It analyzed 571 ischemic stroke patients, calculating their renal function using the eGFR, and identified significant independent risk factors for CKD, including diabetes, high blood pressure, and elevated LDL cholesterol.
- * The findings suggest that ischemic stroke patients are at a heightened risk for CKD, emphasizing the need for proactive management and increased public awareness regarding CKD risks in this population.
Article Synopsis
- Chronic renal disease (CKD) is a significant global health issue, especially prevalent in patients with coronary artery disease (CAD).
- A study involving 527 CAD patients assessed renal function, focusing on risk factors for CKD without considering proteinuria.
- Key findings indicated that age, smoking, diabetes, hypertension, and high systolic blood pressure are major CKD risk factors, with hypertension and diabetes being particularly common in patients with more severe kidney impairment.
Article Synopsis
- - The study investigates serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in chronic kidney disease (CKD) patients to understand their relation to disease severity.
- - Among 69 CKD patients and 12 healthy controls, results showed no significant difference in IL-33 levels, but sST2 levels were higher in CKD patients and correlated significantly with disease severity.
- - The findings suggest that elevated sST2 levels in CKD patients could indicate more severe disease and might be linked to other factors like parathyroid hormone, highlighting sST2's potential role in disease progression.
[Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
Zhonghua Nei Ke Za Zhi
August 2010
Objective: To measure the expression of CD80 and CD86 in renal tissue of lupus nephritis (LN) and explore its mechanism in the development of LN.
Methods: Forty-nine patients with active LN and 9 patients with minor glomerular abnormalities tissues as controls were studied. The expression of CD80 and CD86 in renal tissues was detected by immunohistochemical methods.