Publications by authors named "Xi-Zhen Ma"
Gut microbiota disturbance and systemic inflammation have been implicated in the degeneration of dopaminergic neurons in Parkinson's disease (PD). How the alteration of gut microbiota results in neuropathological events in PD remains elusive. In this study, we explored whether and how environmental insults caused early neuropathological events in the substantia nigra (SN) of a PD mouse model.
View Article and Find Full Text PDFArticle Synopsis
- Cell senescence plays a significant role in the development of Parkinson's disease (PD), with α-synuclein aggregation and iron deposition being key factors in this process.
- In a mouse model, overexpression of α-syn-A53T led to increased inflammation, cell senescence markers, and mitochondrial dysfunction, but noticeable neuronal loss was only evident after four weeks.
- Iron overload exacerbated oxidative stress and cell senescence triggered by α-syn-A53T, while reducing iron levels showed promise in improving outcomes, suggesting a potential therapeutic avenue for PD.