Clinical and biomarker analyses of sintilimab plus gemcitabine and cisplatin as first-line treatment for patients with advanced biliary tract cancer.

The prognosis of biliary tract cancer (BTC) remains unsatisfactory. This single-arm, phase II clinical trial (ChiCTR2000036652) investigated the efficacy, safety, and predictive biomarkers of sintilimab plus gemcitabine and cisplatin as the first-line treatment for patients with advanced BTCs. The primary endpoint was overall survival (OS).

Atmospheric deposition of nitrogen at five subtropical forested sites in South China.

Elevated concentrations of reactive nitrogen (N) in precipitation have been reported for many cities in China. Due to increased use of fossil fuels and expansion in agriculture, further increases in deposition of ammonia (NHx) and reactive N oxides (NOy) are predicted. Increased deposition of reactive N is likely to affect N dynamics and N runoff in forest ecosystems.