[Interrelation between the hypothalamic arcuate nucleus and the bone variation of osteoporosis in rats].

This study investigated the interrelation between the hypothalamic arcuate nucleus (ARC) and the bone variation of osteoporosis in rats. Four animal models of ovariectomy-induced osteoporosis (OVX), glucocorticoid-induced osteoporosis (GIOP), retinoic acid-induced osteoporosis (RAOP) and senile osteoporosis (SOP) were used to study the influence of osteoporosis on ARC. Ovariectomized rats were further treated with thymopeptide, ciclosporin and exercise respectively to detect the changes of ARC nerve cells number.

[Relationship between the levels of sex hormones and loss of bone mass in aging male rats].

Objective: To investigate the relationship between the level of sex hormones and the loss of bone mass in aging male rats.

Methods: Thirty male Sprague-Dawley rats were equally divided into five age groups and sacrificed at 35, 70, 160, 700 and 800 postnatal days (PD) , followed by measurement of the % Tb x Ar, Tb x Th, Tb x N and Tb x SP by bone histomorphometry and detection of the levels of serum testosterone (T) and estradiol (E2) by radioimmunoassay. The relationship between the changes of the T and E2 levels and those of bone histomorphometry was analyzed.

[Mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats].

Aim: To investigate the influence of CCE3 on bone mineral element metabolism and relative hormone in ovariectomized rats.

Methods: 24 female SD rats were divided randomly into 4 groups (n = 6): (1) Normal control; (2) sham ovariectomy; (3) ovariectomy(OVX); (4) OVX + CCE3.

Results: (1) Ca, Mg, S, Co, Mn, Zn reduced obviously and P increased in the bone of the OVX rats.

[The effect of hypothalamic arcuate nucleus damaged by monosodium glutamate on skeleton in rat].

Aim: To explore the effect of hypothalamic arcuate nucleus (ARC) on the skeleton in rat.

Methods: Newborn SD rats were injected by 10% MSG 4 g/kg hypodermically once every other day until the 10th day postnatally, meanwhile, the newborn rats in control group were given by equal volume of normal saline. After surviving for 200 days, 6 female rats in each group were killed and their hypothalami were made into sections (4 microm) and stained with HE.

[Effect of exercise on bone mineral element metabolism and relative hormones in ovariectomized rats].

Aim: To investigate the effect of exercise on bone mineral element metabolism and relative hormones in ovariectomized rats.

Methods: 24 female SD rats were divided randomly into 4 groups: (1) normal control, (2) sham ovariectomy, (3) ovariectomy (OVX), (4) OVX + exercise.

Results: (1) Ca, Mg, S,Co,Mn, Zn reduced obviously and P increases in bone of the OVX rats.