Publications by authors named "Xi-Yan Ma"
Article Synopsis
- Early administration of Paxlovid in severe COVID-19 patients with hypoxemia can reduce hospitalization time and improve viral clearance, although it doesn't significantly affect overall prognosis.
- The study compared outcomes of patients receiving Paxlovid within 5 days of symptom onset (early group) to those receiving it later (delayed group), finding no major differences in 28-day health outcomes between the two groups.
- Key risk factors for worse prognosis included having three or more underlying diseases, elevated d-dimer levels, and multi-organ dysfunction syndrome (MODS).
Background: Hypoxic pulmonary hypertension (HPH) is a common complication of chronic lung disease, which severely affects the survival and prognosis of patients. Several recent reports have shown that DNA damage and repair plays a crucial role in pathogenesis of pulmonary arterial hypertension. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a part of DNA-PK is a molecular sensor for DNA damage that enhances DSB repair.
View Article and Find Full Text PDFFive sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment.
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