Publications by authors named "Xi-Xi Gu"

Background: Ischemic stroke (IS) is a commonly seen cerebrovascular disease which seriously endangers the health of middle age and old people. However, its etiology and pathogenesis have not yet fully comprehended. miR-30 gene is a novel gene which may be involved in IS.

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Lung cancer treatment has transitioned fully into the era of immunotherapy, yielding substantial improvements in survival rate for patients with advanced non-small cell lung cancer (NSCLC). In this report, we present a case featuring a rare epidermal growth factor receptor () mutation accompanied by high programmed death-ligand 1 () expression, demonstrating remarkable therapeutic efficacy through a combination of immunotherapy and chemotherapy. A 77-year-old male with no family history of cancer suffered from upper abdominal pain for more than half months in August 2020 and was diagnosed with stage IV (cT3N3M1c) lung squamous cell carcinoma (LUSC) harboring both a rare p.

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Background: Ischemic stroke (IS) represents a major cause of morbidity and mortality across the globe. The aberrant expression of miR-365 has been found to be implicated in a wide array of human diseases, including atherosclerosis and cancer. Studies on single-nucleotide polymorphisms (SNPs) in miRNA genes can help gain insight into the susceptibility to the condition.

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Centenarians, who show mild infections and low incidence of tumors, are the optimal model to investigate healthy aging. However, longevity related immune characteristics has not been fully revealed largely due to lack of appropriate controls. In this study, single-cell transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) derived from seven centenarians (CEN), six centenarians' offspring (CO), and nine offspring spouses or neighbors (Control, age-matched to CO) are performed to investigate the shared immune features between CEN and CO.

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Article Synopsis
  • - The study investigates the link between systemic lupus erythematosus (SLE) and anxiety, suggesting that the immune system might trigger anxiety in patients.
  • - Researchers analyzed patient data using electronic lupus symptom records and the Hospital Anxiety and Depression Scale (HADS), selecting 107 participants for further study.
  • - By examining T-cell and B-cell subsets through multicolor flow cytometry and machine learning methods, they found significant differences in 13 T-cell subsets between SLE patients with anxiety and those without, highlighting the potential role of T cells in anxiety disorders.
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Background: Evidence suggests that poor mental health (MH) is a risk factor for the health of older adults. Dietary diversity is considered to be related to healthy aging. However, the relationship between diet and MH is still unclear.

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Hypoxia-inducible factor-3α (HIF-3α), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia. It is believed that HIF plays crucial roles in stroke-related diseases. However, there are no reports on the association between HIF-3α genetic variants and ischemic stroke (IS) susceptibility.

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  • The study focused on a specific multidrug-resistant isolate, HNK130, from a chicken, which showed resistance to 13 antibiotics, including key classes like cephalosporins and fosfomycin.
  • Researchers discovered that the isolate carried a single large plasmid (∼180-kb) that did not transfer through conjugation, and identified three variants of this plasmid through electro-transformation.
  • All variants exhibited a mosaic structure with specific genes identified within them, revealing different stability in the transformants, suggesting implications for the spread of antibiotic resistance.
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Background: Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles including promotion of angiogenesis, inhibition of apoptosis and inflammation and regulation of autophagy. However, the effects of genetic variation (single nucleotide polymorphisms, SNPs) of MALAT1 on IS have rarely been explored.

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  • The study evaluated the molecular features and antibiotic resistance of Clostridium difficile found in pigs, chickens, and ducks across five provinces in China during 2015-2016, analyzing 538 rectal swab samples, with a C. difficile positivity rate of 8.2%.
  • Among the positive samples, 88.6% were toxic-producing strains, with the dominant strain being ST11/RT078, mainly isolated from diarrheic piglets; other strains like ST109 showed diverse toxigenic profiles across animal species.
  • All C. difficile isolates were sensitive to key antibiotics like vancomycin and metronidazole but exhibited resistance to several others, including cefot
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Difference in the development of resistance may be associated with the epidemiological spread and drug resistance of different Salmonella enterica serovar strains. In the present study, three susceptible S. enterica serovars, Typhimurium (ST), Enteritidis (SE), and Indiana (SI) strains, were subjected to stepwise selection with increasing ciprofloxacin concentrations.

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Salmonella spp. is one of the most important food-borne pathogens causing digestive tract and invasive infections in both humans and animals. Extended-spectrum β-lactamases (ESBLs) especially the CTX-M-type ESBLs are increasingly being reported worldwide and in China.

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  • The study aimed to analyze the virulence of extended-spectrum β-lactamases (ESBLs) from Escherichia coli in piglets with diarrhea in China, focusing on their molecular epidemiology.
  • A total of 62 E. coli isolates were investigated, with 36 identified as CTX-M producers, which showed significant multidrug resistance and biofilm formation, especially in diarrheic piglets.
  • The research highlighted that these resistant strains often carry transferable plasmids, emphasizing the critical need for controlling the spread of drug-resistant bacteria within the food chain.
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Objective: To observe the curative effect of integrated Chinese and Western medicine on acute cerebral infarction (ACI).

Methods: Two hundred and seventy-nine ACI patients were assigned to two groups. The control group (140 cases) was treated with Western medicine by staging and the treated group (139 cases) was given TCM therapy according to syndrome differentiation on the basis of Western medicine.

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  • A study investigated the effects of Yangxue Qingnao granule (YXQNG) on patients with chronic cerebrovascular insufficiency (CCI) and explored its mechanisms of action.
  • Eighty-three patients were randomly assigned to receive either YXQNG or nimodipine (ND), and their vertigo scores and cerebral blood flow changes were measured before and after treatment.
  • Results showed that YXQNG significantly reduced vertigo scores and improved cerebral blood flow in patients, and also enhanced learning and memory performance in rat models compared to ND, suggesting its effectiveness in treating CCI symptoms.
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