Deep learning for predicting immunotherapeutic efficacy in advanced non-small cell lung cancer patients: a retrospective study combining progression-free survival risk and overall survival risk.

Background: Radiomics based on computed tomography (CT) images is potential in promoting individualized treatment of non-small cell lung cancer (NSCLC), however, its role in immunotherapy needs further exploration. The aim of this study was to develop a CT-based radiomics score to predict the efficacy of immune checkpoint inhibitor (ICI) monotherapy in patients with advanced NSCLC.

Methods: Two hundred and thirty-six ICI-treated patients were retrospectively included and divided into a training cohort (n=188) and testing cohort (n=48) at a ratio of 8 to 2.

Radiomics nomogram for prediction disease-free survival and adjuvant chemotherapy benefits in patients with resected stage I lung adenocarcinoma.

Background: Robust imaging biomarkers are needed for risk stratification in stage I lung adenocarcinoma patients in order to select optimal treatment regimen. We aimed to construct and validate a radiomics nomogram for predicting the disease-free survival (DFS) of patients with resected stage I lung adenocarcinoma, and further identifying candidates benefit from adjuvant chemotherapy (ACT).

Methods: Using radiomics approach, we analyzed 554 patients' computed tomography (CT) images from three multicenter cohorts.

Region growing algorithm combined with morphology and skeleton analysis for segmenting airway tree in CT images.

Background: Automatic segmentation of pulmonary airway tree is a challenging task in many clinical applications, including developing computer-aided detection and diagnosis schemes of lung diseases.

Objective: To segment the pulmonary airway tree from the computed tomography (CT) chest images using a novel automatic method proposed in this study.

Methods: This method combines a two-pass region growing algorithm with gray-scale morphological reconstruction and leakage elimination.

Fusion of quantitative imaging features and serum biomarkers to improve performance of computer-aided diagnosis scheme for lung cancer: A preliminary study.

Objectives: To develop and test a new multifeature-based computer-aided diagnosis (CADx) scheme of lung cancer by fusing quantitative imaging (QI) features and serum biomarkers to improve CADx performance in classifying between malignant and benign pulmonary nodules.

Methods: First, a dataset involving 173 patients was retrospectively assembled, which includes computed tomography (CT) images and five serum biomarkers extracted from blood samples. Second, a CADx scheme using a four-step-based semiautomatic segmentation method was applied to segment the targeted lung nodules, and compute 78 QI features from each segmented nodule from CT images.

Automatic detection of pulmonary nodules in CT images by incorporating 3D tensor filtering with local image feature analysis.

Computer-aided detection (CAD) technology has been developed and demonstrated its potential to assist radiologists in detecting pulmonary nodules especially at an early stage. In this paper, we present a novel scheme for automatic detection of pulmonary nodules in CT images based on a 3D tensor filtering algorithm and local image feature analysis. We first apply a series of preprocessing steps to segment the lung volume and generate the isotropic volumetric CT data.

Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies.

Twin pregnancies have a higher prevalence of intrahepatic cholestasis of pregnancy (ICP) than single pregnancies. It is unknown whether in vitro fertilization-embryo transfer (IVF-ET) influences the fetal outcomes in twin pregnancies complicated by ICP. This study aimed to explore the impact of IVF-ET on the perinatal outcomes of ICP in twin pregnancy.

Computer-aided diagnosis of lung cancer: the effect of training data sets on classification accuracy of lung nodules.

This study aims to develop a computer-aided diagnosis (CADx) scheme for classification between malignant and benign lung nodules, and also assess whether CADx performance changes in detecting nodules associated with early and advanced stage lung cancer. The study involves 243 biopsy-confirmed pulmonary nodules. Among them, 76 are benign, 81 are stage I and 86 are stage III malignant nodules.

[A study of global ecological adaptability and field selection practices of Panax ginseng].

Through the development of ecological suitability analysis of producing area and the selection criteria of farmland cultivation in the global range of ginseng, we aim to provide scientific basis for rational planning, production layout and standardized planting of farmland. We analyze the data based on the ecological factors from 271 sample plots of Panax ginseng, including both the traditional producing regions recorded in past dynasties medicinal works and the popular production regions in the world, using global geographic information system for medicinal plant(GMPGIS) developed by ICMM (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences). We concluded that the suitable producing areas in global for P.

Anti-proliferation and radiosensitization effects of chitooligosaccharides on human lung cancer line HepG2.

Objective: To observe the anti-proliferation and radiosensitization effect of chitooligosaccharides (COS) on human lung cancer cell line HepG2.

Methods: CCK-8 assay was employed to obtain the inhibition ratio of COS on HepG2 cells at 24 h after treatment. The clonogenic assay was used to analyze the cell viability of RAY group and RAY + COS group with X-ray of 0, 1, 2, 4, 6 and 8 Gy, and the cell survival curve was used to analyze the sensitization ratio of COS.

An Aberrant Left Bronchial Artery Originating from the Proximal Ascending Aorta.

The origin of the bronchial arteries (BAs) has numerous anatomical variations. It is important to recognize these variations when performing interventional radiologic procedures in the thorax. We report the case of a 71-year-old man who underwent transarterial infusion chemotherapy for squamous cell carcinoma of the upper lobe of the left lung via a feeding left BA that originated from the proximal ascending aorta.

Endovascular embolization of an aberrant bronchial artery originating from the vertebral artery in a patient with massive hemoptysis.

Endovascular embolization has become an established procedure for the management of massive or recurrent hemoptysis. The bronchial, nonbronchial systemic and pulmonary arteries are possible sources of bleeding, and the major sources of bleeding are the bronchial arteries (BAs). However, the locations of ostia of the BAs have numerous anatomical variations, which can make it technically challenging to identify a bleeding artery.

Endovascular coil embolization of a costocervical trunk pseudoaneurysm after bullectomy with pleural abrasion.

Transarterial embolization (TAE) is less invasive than surgery for the treatment of pseudoaneurysms. Costocervical trunk (CCT) pseudoaneurysms are extremely rare. We herein report an unusual case of a 45-year-old man with a CCT pseudoaneurysm caused by a bullectomy with pleural abrasion, which had been performed to manage a spontaneous pneumothorax.

Bilateral subclavian origin of the bronchial arteries combined with absence of other origins.

There are numerous anatomical variations of the sites of origin of the bronchial arteries (BAs). A subclavian origin of a BA involves an aberrant artery that originates from the subclavian artery (SCA) or its branches. However, the aberrant artery usually originates directly from the SCA, and an SCA-origin BA arising from the branches of the SCA is rare.

Endovascular embolization of bronchial artery originating from the upper portion of aortic arch in patients with massive hemoptysis.

Purpose: Our experience with endovascular embolization (EVE) of the bronchial artery (BA) originating from the upper portion of the aortic arch (AA) in six patients is described.

Methods: Altogether, 818 patients with hemoptysis underwent multidetector row computed tomography angiography (MDCTA) before EVE or AA angiography during EVE. Aberrant BAs originating from the upper portion of the AA were the source of massive hemoptysis in six patients (0.

Detection of rib metastases in patients with lung cancer: a comparative study of MRI, CT and bone scintigraphy.

We retrospectively investigated the imaging findings of bone scintigraphy, chest CT and chest MRI in 55 cases of lung cancer. The sensitivity, specificity and accuracy of the detection of rib metastases were compared between imaging modalities on both a per-lesion and a per-patient basis. On a per-lesion basis, MRI sensitivity and accuracy were significantly higher than that of bone scintigraphy and CT (P<0.

Common trunk of left internal thoracic artery and thyrocervical trunk arising from the ipsilateral vertebral artery.

The sites of origin of the branches of the subclavian artery depict numerous anatomical variations. However, a common trunk of the internal thoracic artery (ITA) and thycocervical trunk (TCT) arising from the vertebral artery is a rare anatomical finding. Herein, we present the first case in which the common trunk of the left ITA and TCT arose from the ipsilateral proximal vertebral artery as discovered on pre-therapeutic evaluation by multidetector-row computed tomography and clearly confirmed by selective angiography.

Aberrant left inferior bronchial artery originating from the left gastric artery in a patient with acute massive hemoptysis.

Massive hemoptysis is a life-threatening condition, and the major source of bleeding in this condition is the bronchial circulation. Bronchial artery embolization is a safe and effective treatment for controlling hemoptysis. However, the sites of origin of the bronchial arteries (BAs) have numerous anatomical variations, which can result in a technical challenge to identify a bleeding artery.

Endovascular embolization of the complete type of anomalous systemic arterial supply to normal basal lung segments: a report of four cases and literature review.

The complete type of anomalous systemic arterial supply to normal basal lung segments is characterized by anomalous systemic artery supply to all or some of the normal basal segments with an absent corresponding pulmonary artery. Surgical intervention generally is required. This study reports on four patients with this anomaly with hemoptysis or a combination of other symptoms who underwent successful transarterial embolization using metallic coils or an Amplatzer vascular plug.

Characterization of pancreatic metastases from primary lung cancer using magnetic resonance imaging.

Aim: To evaluate magnetic resonance (MR) imaging of pancreatic metastases secondary to primary lung cancers.

Materials And Methods: Eleven cases included T1-weighted, T2-weighted, and spectral presaturation attenuated inversion recovery T2-weighted images.

Results: Of the 21 total pancreatic lesions evaluated, 10 exhibited a peripheral rim of high signal intensity, 9 displayed a homogeneous signal intensity, and 2 lesions demonstrated a heterogeneous pattern of contrast enhancement.

CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer.

Background: Ovarian cancer is one of the most common cancers and can be treated with microtubule-targeting drugs. Checkpoint with forkhead and ring finger domains (CHFR) is a protein implicated in cancer sensitivity to microtubule-targeting drugs. Whereas CHFR downregulation, often with CHFR promoter hypermethylation, has been identified in a large number of tumor types, it has not been in ovarian cancer.

[Pulmonary sarcoidosis: CT features and the changes after glucocorticoid therapy].

Objective: To investigate the CT features of pulmonary sarcoidosis and to follow the changes after glucocorticoid therapy.

Methods: CT scans and clinical data of 90 patients with histologically confirmed pulmonary sarcoidosis were retrospectively reviewed. CT follow-up was carried out 5-30 d following therapy in 43 cases.

[The interaction between microsomal epoxide hydrolase polymorphisms and indoor pollution in non small cell lung cancer].

Objective: To determine the interaction between indoor air pollution and mEH gene polymorphisms.

Methods: Blood samples from 222 non small cell lung cancer patients and 222 healthy people were characterized by PCR and PCR-RFLP methods. The interaction coefficients were determined through unconditional logistic regression model.

[The clinical value and characteristics of subclavian artery angiography for hemoptysis due to pulmonary tuberculosis].

Objective: To study the signs of subclavian artery angiography for hemoptysis due to pulmonary tuberculosis and to evaluate its clinical use in artery embolization.

Methods: Thirty-nine patients with hemoptysis due to pulmonary tuberculosis underwent subclavian artery angiography after artery embolization performed in the hemorrhagic branches of descending aorta. Of the 39 cases, 25 had severe pulmonary fibrosis or were complicated with cavity formation, aspergilloma, pleural thickening and postoperative thorax.

Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin.

To investigate the biological effect of mdm2 in human colorectal adenocarcinoma LoVo cells, three mdm2siRNA constructions were recombined and transient transfected into human colorectal adenocarcinoma LoVo cells with low differentiation character in vitro. The results showed that mdm2siRNA3 reduced mRNA level of mdm2 and protein level of mdm2, leading to proliferation inhibition on LoVo cells, and reduced tumor growth in nude mice. It was found that depletion of MDM2 in this pattern promoted apoptosis of LoVo cells and Cisplatin (DDP) treated in the mdm2siRNA3 transfected cell population would result in a substantial decrease by MTT colorimetry.

Behavioral and functional MRI study of attention shift in human verbal working memory.

The tripartite model of memory proposed the requirement of attentional switching when accessing different items in working memory [J. Exp. Psychol.