[The expression of thrombospondin-1 in serum and pulmonary arterioles of hypoxic pulmonary hypertension rats].

Objective: To investigate the expression of thrombospondin-1 (TSP-1) in serum and pulmonary arterioles of rats with hypoxic pulmonary hypertension.

Methods: Twenty male Wistar rats were divided into two groups and exposed to air and isobaric hypoxia for 3 weeks respectively. The mean pulmonary artery pressure (mPAP) was measured by right cardiac catheterization.

[Expression of thrombospondin-1 in the lung of hypoxic pulmonary hypertension rats].

Objective: To investigate the expression of thrombospondin-1(TSP-1) in the lung of hypoxia-induced pulmonary hypertension rats.

Methods: Thirty male Wistar rats were divided into two groups, pulmonary hypertension group and control group. The mice in experimental group were exposed to isobaric hypoxia for 3 weeks, and those in control group were exposed to air.

[Effect of adenoviral E1A-involved apoptosis of rat alveolar epithelial cells and human lung adenocarcinoma epithelial cell line].

Aim: The relationship between latent adenovirus infection and apoptosis of airway epithelial cell have not been well documented.We want to illustrating the roles of adenovirus E1A protein on the apoptotic alveolar epithelial in response to TNF-alpha.

Methods: The expression vector for expressing adenovirus E1A protein was transfected into CCL149 and A549 cell respectively.

[The effect of nasal continuous positive airway pressure on endothelial function in obstructive sleep apnea-hypopnea syndrome with coronary heart disease].

Objective: To study the association between the indices of endothelial function in obstruction sleep apnea-hypopnea syndrome (OSAHS) and coronary heart disease (CHD) and the effect of nasal continuous positive airway pressure (nCPAP) on the combination of OSAHS and CHD.

Methods: A total of 80 subjects were prospectively recruited into four groups including control, OSAHS, CHD, OSAHS with CHD groups, with 20 subjects each. The indices of sleep apnea, serum nitric oxide (NO), and plasma endothelial-1 (ET-1) were measured.

[Corticosteroid therapy and changes in chest radiogram in five patients with severe acute respiratory syndrome].

Objective: To investigate the relationship between corticosteroid therapy and kinetic changes in chest X-ray in five patients with severe acute respiratory syndrome (SARS).

Methods: With the identical underlying therapy (levofloxacin or ceftriaxone and macrolide), intravenous methylprednisolone was given at 80 mg twice a day in five patients, and its effect on the development of chest radiogram was observed.

Results: Chest X-rays radiogram showed significant changes until peak stage (4-12 days) with the same doses of methylprednisolone, but it was dissolved consistently afterwards.