Synopsis of recent research by authors named "Xi-Wei Ji"
- Xi-Wei Ji's research primarily focuses on model-informed drug development (MIDD) approaches to optimize the pharmacokinetic and pharmacodynamic properties of new antibiotics and anticancer agents, particularly against challenging bacterial infections and cancer treatments.
- His studies have demonstrated the efficacy of antibiotic combinations like cefoperazone/sulbactam against Enterobacteriaceae, and novel compounds like benapenem through comprehensive pharmacokinetic/pharmacodynamic modeling and clinical trials.
- Additionally, Ji has investigated the implications of renal function on the pharmacokinetics of drugs like vancomycin in Chinese adult patients and explored therapeutic strategies in breast cancer through compounds such as TM208, addressing mechanisms of drug resistance and potential treatment pathways.
