Publications by authors named "Xi-Tong Song"
Article Synopsis
- SSAT-1, an enzyme linked to early cancer detection, can be studied using a new nanopore technology that detects acetylamantadine, a specific product formed from the drug amantadine.
- The use of γ-cyclodextrin in this method allows for precise detection of acetylamantadine even in the presence of large amounts of amantadine, showing improved performance over previous methods.
- This study also explores how structural properties of various compounds influence their interaction with cyclodextrins, providing valuable insights for future drug and cyclodextrin research.
Selective recognition of short oligonucleotides at the single-molecule level is particularly important for early disease detection and treatment. In this work, polydopamine (PDA)-coated nanopores were prepared via self-polymerization as a solid-state nanopore sensing platform for the recognition of oligonucleotide C (PolyC). The PDA coating possesses abundant active sites, such as indole, amino, carboxyl, catechol, and quinone structures, which had interactions with short oligonucleotides to slow down the translocation rate.
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- Protein identification at the single-molecule level is challenging, particularly for those with similar structures, but solid-state nanopores are being used as sensitive biosensors to assist with this.
- The study focuses on two proteins, ferritin and apo-ferritin, which have the same exterior but different interior structures, demonstrating that nanopore size is crucial for effective discrimination between them.
- By adjusting nanopore size, the researchers found that larger pores did not differentiate the proteins, whereas smaller pores allowed for clear discrimination through current fluctuations caused by the proteins' movements, suggesting this method could be applied to other similar proteins.