Publications by authors named "Xi-Ting Liu"

Article Synopsis
  • A clinical trial was conducted to compare gene-based dosing of 6-mercaptopurine (6-MP) to standard dosing in Chinese children with acute lymphoblastic leukemia (ALL), focusing on those with low- or intermediate-risk.
  • The gene-based dosing resulted in a 2.2-fold decrease in myelosuppression compared to standard dosing, using approximately half the standard dose, and significantly reduced the risk of leukopenia.
  • No major differences were found in hepatotoxicity or metabolite concentrations in the blood between the two treatment groups, suggesting that gene-based dosing may be a safer alternative for this patient population.
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Methane is supersaturated in surface seawater and shallow coastal waters dominate global ocean methane emissions to the atmosphere. Aerobic methane oxidation (MOx) can reduce atmospheric evasion, but the magnitude and control of MOx remain poorly understood. Here we investigate methane sources and fates in the East China Sea and map global MOx rates in shallow waters by training machine-learning models.

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Purpose: Inflammation has a significant impact on CYP3A activity. We hypothesized that this effect might be age dependent. Our objective was to conduct a population pharmacokinetic study of midazolam in mice at different developmental stages with varying degrees of inflammation to verify our hypothesis.

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Article Synopsis
  • - Dasatinib, a drug used to treat CBF-AML, was tested in a study with 20 children to assess its pharmacokinetics and safety when combined with standard chemotherapy.
  • - Blood samples were taken to analyze dasatinib concentrations, revealing that the drug’s effectiveness (measured by AUC) in children was comparable to that in adults, with some adverse effects mostly being mild (grade 1/2).
  • - The study found high rates of complete remission (95%) and molecular response (75.5%) in pediatric patients, indicating that dasatinib is well-tolerated and effective for treating CBF-AML in children.
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Dimethylated sulfur compounds play an important role in global sulfur cycle. We investigated the seasonality of dimethylsulfoniopropionate (DMSP), dimethylsulfoxide (DMSO), dimethylsulfide (DMS) and associated processes in two north China marginal seas during 2014 and 2016. High concentrations of DMS, DMSP and DMSO occurred in summer/spring, while the lowest were observed in winter.

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Aims: Recently, letrozole has been used off-label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained primarily from Caucasian children. A simple extrapolation of the data to Chinese paediatric populations is questionable because of the substantial ethnic differences between the two populations.

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Aims: This open-label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for the treatment of chemotherapy-induced neutropenia in children with acute leukaemia.

Methods: PEG-rhG-CSF was administered as a single 100 mcg/kg (3 mg maximum dose) subcutaneous injection at the end of each chemotherapy period when neutropenia occurred. Blood samples were obtained from patients treated with PEG-rhG-CSF.

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The spatial distributions, fluxes, and environmental effects of non-methane hydrocarbons (NMHCs) were investigated in the Yellow Sea (YS) and the East China Sea (ECS) in spring. The average concentrations of ethane, propane, i-/n-butane, ethylene, propylene and isoprene in the seawater were 18.1 ± 6.

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First dose prediction is challenging in neonates. Our objective in this proof-of-concept study was to perform a pharmacokinetic (PK) bridging study from juvenile mice to neonates for drugs metabolized by CYP3A. We selected midazolam and clindamycin as model drugs.

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Aims: Chinese children are more susceptible to the development of thiopurine-induced leukopenia compared with Caucasian populations. The aim of our study was to establish a 6-mercaptopurine (6-MP) dose-concentration-response relationship through exploration of pharmacogenetic factors involved in the thiopurine-induced toxicities in Chinese paediatric patients afflicted by acute lymphoblastic leukaemia (ALL).

Methods: Blood samples were obtained from ALL children treated with 6-MP.

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