Publications by authors named "Xi-Qiao Xu"
Biopharm Drug Dispos
March 2020
Article Synopsis
- Methotrexate (MTX) shows a lot of variation in how it works in different individuals, especially in children with medulloblastoma treated with high doses, which has not been thoroughly studied before.
- A population pharmacokinetic analysis was performed on 660 serum samples from 105 pediatric patients using a specific modeling method to analyze how MTX is processed in the body.
- The final model identified weight, kidney function, and the use of dexamethasone as key factors affecting how quickly MTX is cleared from the body, and this could help tailor treatments to individual patient needs.
