Publications by authors named "Xi-Ming Lu"

The G-triplex is a kind of DNA structure formed by G-rich sequences. Previous studies have shown that it is an intermediate for the folding of G-quadruplex and has an antiparallel structure. The folding dynamics of this G-triplex structure, however, have not been well studied until now.

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Article Synopsis
  • G-quadruplexes are unique structures found at the ends of human telomeres, playing a crucial role in maintaining genome stability and protecting chromosome ends.
  • The study focused on how different monovalent cations, specifically sodium (Na), potassium (K), and lithium (Li), affect the folding kinetics of G-quadruplexes, highlighting significant variations in response to these ions.
  • Surprisingly, lithium, previously thought to have no impact, was found to significantly alter the folding kinetics, changing the folding fraction for Na-induced G-quadruplexes and increasing folding rates for K-induced ones, providing new insights into the folding mechanisms of these important structures.
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Objective: To observe the effect of Cornus officinalis fruit core extract on cardiac hypertrophy induced by two kidney two clip (2K2C) and its mechanism.

Methods: Male Sprague-Dawley rats were randomly divided into 4 groups: sham-operated group, model group and treatment groups (300, 600 mg/kg). Rats were intragastric administered medicine for 4 weeks from the fourth week after surgery.

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Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not well clarified. In this work, we have used dynamic light scattering and various stopped-flow assays to study the active form and kinetic mechanism of BLM in DNA unwinding.

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