Publications by authors named "Xi-Ming Lu"
The G-triplex is a kind of DNA structure formed by G-rich sequences. Previous studies have shown that it is an intermediate for the folding of G-quadruplex and has an antiparallel structure. The folding dynamics of this G-triplex structure, however, have not been well studied until now.
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- G-quadruplexes are unique structures found at the ends of human telomeres, playing a crucial role in maintaining genome stability and protecting chromosome ends.
- The study focused on how different monovalent cations, specifically sodium (Na), potassium (K), and lithium (Li), affect the folding kinetics of G-quadruplexes, highlighting significant variations in response to these ions.
- Surprisingly, lithium, previously thought to have no impact, was found to significantly alter the folding kinetics, changing the folding fraction for Na-induced G-quadruplexes and increasing folding rates for K-induced ones, providing new insights into the folding mechanisms of these important structures.
Objective: To observe the effect of Cornus officinalis fruit core extract on cardiac hypertrophy induced by two kidney two clip (2K2C) and its mechanism.
Methods: Male Sprague-Dawley rats were randomly divided into 4 groups: sham-operated group, model group and treatment groups (300, 600 mg/kg). Rats were intragastric administered medicine for 4 weeks from the fourth week after surgery.
Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not well clarified. In this work, we have used dynamic light scattering and various stopped-flow assays to study the active form and kinetic mechanism of BLM in DNA unwinding.
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