Publications by authors named "Xi-Mei Zhu"

Article Synopsis
  • * Results show no overall significant relationship between caffeine intake and amyloid positivity, but a notable inverse relationship was found in males, meaning caffeine may reduce the risk of amyloid presence for them.
  • * No significant effect of caffeine was observed for females, and the research indicates further investigations are necessary to understand the underlying mechanisms of caffeine's influence on brain health.
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  • * It identifies specific brain structures, especially the inferior orbitofrontal gyrus, that are linked to both depression and emotional recognition, indicating how changes in these regions might influence depressive symptoms.
  • * The findings suggest that certain brain areas (like the frontal pole and precuneus) are more active in individuals with depression when faced with negative stimuli, highlighting the complex neurobiological mechanisms at play.
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Background: Vaccination is an important preventive measure against the coronavirus disease 19 (COVID-19) pandemic. We aimed to examine the willingness to vaccination and influencing factors among college students in China.

Methods: From March 18 to April 26, 2021, we conducted a cross-sectional online survey among college students from 30 universities in Wuhan, Hubei Province, China.

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During the pandemic era, quarantines might potentially have negative effects and disproportionately exacerbate health condition problems. We conducted this cross-sectional, national study to ascertain the prevalence of constant pain symptoms and how quarantines impacted the pain symptoms and identify the factors associated with constant pain to further guide reducing the prevalence of chronic pain for vulnerable people under the pandemic. The sociodemographic data, quarantine conditions, mental health situations and pain symptoms of the general population were collected.

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Article Synopsis
  • - The COVID-19 pandemic has posed significant challenges to public health, with vaccines being a key preventive tool, and understanding related psychological stress is vital for improving vaccine acceptance.
  • - An online survey conducted in China involved over 34,000 participants to assess psychological stress levels regarding COVID-19 vaccination at different stages, revealing a mean stress score of 3.90 that significantly decreased after receiving information about vaccines and after vaccination itself.
  • - Factors contributing to higher stress included being younger, having lower education, chronic health issues, mistrust in vaccine efficacy, past allergic reactions to vaccines, and existing mental health symptoms, with some stress factors persisting even post-vaccination.
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The present study assessed the willingness of the general population to receive COVID-19 vaccines and identified factors that influence vaccine hesitancy and resistance. A national online survey was conducted from 29 January 2021 to 26 April 2021 in China. Multinomial logistic regression analyses were conducted to identify factors that influence vaccine hesitancy and resistance.

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Sleep deprivation (SD) is increasingly common in modern society, which can lead to the dysregulation of inflammatory responses and cognitive impairment, but the mechanisms remain unclear. Emerging evidence suggests that gut microbiota plays a critical role in the pathogenesis and development of inflammatory and psychiatric diseases, possibly via gut microbiota-brain interactions and neuroinflammation. The present study investigated the impact of SD on gut microbiota composition and explored whether alterations of the gut microbiota play a causal role in chronic inflammatory states and cognitive impairment that are induced by SD.

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Dementia is one of the greatest global challenges for public health; however, the relationship between anticholinergic drugs and dementia remains unclear. The aim of the present study was to perform a systematic review and meta-analysis of the predictive roles of anticholinergic drugs in dementia risk. After pooling fourteen longitudinal and case-control studies with a total of 1,564,181 subjects, anticholinergic drug use was associated with an increased risk of all-cause dementia and Alzheimer's disease.

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Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance.

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In this study, the antithrombotic and thrombolytic ability of second fermented extract of Ophiopogon japonicus (FEOJ) was verified in thrombosis-induced rats. Thrombosis was induced by oral administration of 2% carrageenan for 4 weeks. Five experimental groups (n = 9/group) involved in the study were control group, thrombosis group, low-dose FEOJ group (2 mL/kg, low-dose Ophiopogon japonicus [LOJ]), middle-dose FEOJ group (6 mL/kg, medium-dose Ophiopogon japonicus [MOJ]), and high-dose FEOJ group (12 mL/kg, high-dose Ophiopogon japonicus [HOJ]).

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Objectives: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models.

Methods: MSP flower extract was extracted in 99.

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