Publications by authors named "Xi-Jing He"

Objective: To explore mechanism of piracetam for the treatment of spinal cord injury in rats through mitogen-activated protein kinase (MAPK) pathway.

Methods: Fifty-four healthy 6-week-old SD female rats with body weight of 80 to 100 g were divided into sham operation group, spinal cord injury group and piracetam group by random number table method, with 18 rats in each group. Spinal cord injury model was established in spinal cord injury group and piracetam group using percussion apparatus, while sham operation group did not damage spinal cord.

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Article Synopsis
  • A mobile artificial lumbar complex (MALC) was developed for reconstructing goat spines after subtotal lumbar resection and assessed for stability and motor function post-surgery.
  • The study involved 18 male boer goats divided into three groups: control, fusion, and non-fusion, with varying surgical interventions and the use of 3D printed MALC.
  • Results indicated successful positioning of the MALC without complications and no significant differences in range of motion for the lumbar intervertebral spaces after six months.
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Objective: To study the effects and mechanisms of miR-181a-5p on the proliferation, cycle and migration of HOS osteosarcoma cells.

Methods: Real-time quantitative PCR was used to detect the expression of miR-181a-5p and HOXB4 in osteoblast hFOB1.19 cell line and osteosarcoma cell lines (HOS, U2OS, MG63).

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Spinal cord injury is a severe central nervous system disease, which will cause a series of complex pathophysiological changes and activate a variety of signaling pathways including Notch signaling. Studies have evidenced that activation of the Notch signaling pathway is not conducive to nerve repair and symptom improvement after spinal cord injury. Its mechanisms include inhibiting neuronal differentiation and axon regeneration, promoting reactive astrocyte proliferation, promoting M1 macrophage polarization and the release of proinflammatory factors, and inhibiting angiogenesis.

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Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor α, interleukin-6, and interleukin 1 β. Lithium inhibited pyroptosis and reduced inflammation by inhibiting Caspase-1 expression, reducing the oxidative stress response, and inhibiting activation of the Nod-like receptor protein 3 inflammasome.

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Article Synopsis
  • Spinal cord injury is a severe neurological condition with limited effective treatments, highlighting the need for alternative therapies.
  • Olfactory ensheathing cells are promising for promoting nerve regeneration due to their various biological functions, including supporting axon growth and reducing inflammation.
  • Recent advancements in bioengineering and tissue engineering aim to enhance the therapeutic potential of olfactory ensheathing cells, providing new strategies for improving spinal cord injury treatments.
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Although tumor necrosis factor α (TNF-α)-mediated inflammation significantly impacts osteoporosis, the mechanisms underlying the osteogenic differentiation defects of bone marrow-derived mesenchymal stem cells (BM-MSCs) caused by TNF-α remain poorly understood. We found that TNF-α stimulation of murine BM-MSCs significantly upregulated the expression levels of several microRNAs (miRNAs), including let-7f-5p, but this increase was significantly reversed by treatment with the kinase inhibitor BAY 11-7082. To study gain- or loss of function, we transfected cells with an miRNA inhibitor or miRNA mimic.

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Objective: To investigate expression of Semaphorin 3A in rats after spinal cord injury and explore possible mechanism of inhibiting of axonal regeneration after SCI.

Methods: Forty healthy female SD rats, 8 weeks old, weighing (210.00±9.

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Objective: To explore the short-term clinical efficacy of single-stage cervical spondylotic radiculopathy (CSR) between the minimally invasive Key-hole technique and anterior cervical Zero profile intervertebral fusion system (Zero-P).

Methods: A retrospective analysis was performed on 45 patients who underwent surgical treatment for CSR from January 2017 to January 2020, including 21 in Key hole group (12 males and 9 females), followed up for 10-22(13.2±2.

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Cell transplantation is a potential treatment for spinal cord injury. Olfactory ensheathing cells (OECs) play an active role in the repair of spinal cord injury as a result of the dual characteristics of astrocytes and Schwann cells. However, the specific mechanisms of repair remain poorly understood.

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  • The study aimed to determine if lithium has neuroprotective benefits by enhancing autophagy in nerve cells.
  • Four groups of SH-SY5Y cells were tested, including a control group, a model group exposed to H₂O₂, a lithium-treated group, and a group treated with 3-MA (an autophagy inhibitor).
  • Results showed that lithium significantly improved cell survival compared to the model group, suggesting lithium promotes survival of damaged nerve cells, likely through inducing autophagy.
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Study Design: An experimental animal study of treatment of spinal cord injury (SCI).

Objective: This report aims to evaluate the in vivo effects of butylphthalide NBP on SCI biology and to explore its potential mechanism.

Summary Of Background Data: SCI causes great damage to humans.

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  • - Artificial vertebral implants are effective for treating spinal conditions, but fusion implants can lead to complications like joint degeneration and loss of spinal flexibility.
  • - Movable artificial vertebral bodies aim to restore normal spinal movement and minimize complications by incorporating designs like ball socket joints or elastic deformation.
  • - While 3D printing technology holds promise for creating customized prosthetics, challenges such as high costs and slow production rates remain, and further research on materials and long-term clinical outcomes is needed.
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Objective: Using the CT three-dimensional reconstruction to measure the activity degree of atlanto-occipital joint and the atlantoaxial joint in different directions and its coupling movement in healthy volunteers, and three dimensional motion range of the maximum rotation position of the upper cervical spine of cervical spondylosis patients, and to analyze the differences, verifing the reliability of the method at the meantime.

Methods: From January 2014 to June 2015, 20 healthy adult subjects(healthy adult group), and 26 patients with cervieal spondylosis(cervical spondylosis group) were selected. In healthy adult group, there were 11 males and 9 females, aged from 22 to 26 years old with an average of (24.

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Objective: To investigate multilineage-differentiating stress-enduring (Muse) by immunomagnetic bead screening from Wharton's jelly mesenchymal stromal cells(WJ-MSCs), and explore transplantation of Muse cell for safety and effectivensess of sub acute cord injury in rats.

Methods: Donated Wharton's Jelly-mesenchymal stromal cells (WJ-MSCs) were successfully derived from a human umbilical cord by a series of procedures namely physical isolation of Wharton's Jelly from cord membrane, collagenase and trypsin treatment and density gradient centrifugation. Magnetic activated cell sorting was performed to specifically select SSEA3+ Muse cells, and flow cytometry and immunocytochemistry were used to identify further.

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Objective: To study and measure the anatomic structure of lumbar vertebral endplate structure in healthy adults by computed tomography(CT) technique in order to provide a useful guidance for the optimal design and clinical application of lumbar prostheses.

Methods: Sixty healthy adults (male and female equals) were recruited for full-waist CT scan after signing the informed consent form in the imaging department of the Second Affiliated Hospital of Xi'an Jiaotong University. The scanning data was imported into the computer aided software Mimics 16.

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  • The study aimed to compare the effectiveness of rapid prototyping drill navigation templates for pedicle screw fixation against traditional anatomical landmark techniques in spinal surgery using existing literature.
  • It involved analyzing data from randomized controlled trials and various case-control studies, screening relevant research, and utilizing specific evaluation methods to assess study quality.
  • Findings indicated that navigation template-assisted surgeries significantly improved screw placement accuracy, reduced operative time, and minimized blood loss compared to conventional methods, showcasing its advantages in spinal disease treatment.
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Objective: To investigate the validity of Coda Motion Analysis System for measuring cervical lateral flexion in normal adults in order to explore a new measuring tool for clinical and research practice.

Methods: A total of 43 participants were involved in the study. Cervical range of lateral flexion were measured with Coda Motion Analysis System and "gold standard" X-ray simultaneously.

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Lithium promotes autophagy and has a neuroprotective effect on spinal cord injury (SCI); however, the underlying mechanisms remain unclear. Therefore, in this study, we investigated the effects of lithium and the autophagy inhibitor 3-methyladenine (3-MA) in a rat model of SCI. The rats were randomly assigned to the SCI, lithium, 3-MA and sham groups.

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The cervical screw fixation has been used widely in the clinic setting due to the high fusion rate, immediate fixation of the surgical segment and good correction of the deformity. However, owing to the variation of anatomical structures and the narrow pedicle screws, it's rather difficult to implant the screws through traditional methods. The perforation rate of the screw is high, which can cause serious complications such as neurovascular injury.

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