Publications by authors named "Xi-Dong Wu"
DOP1 leucine zipper-like protein A (DOPEY1), a member of the DOPEY family, is mainly localized in the Golgi apparatus, endosomes, and cytoplasmic compartments within cells. The involvement of DOPEY1 in H. pylori infection-induced carcinogenesis has remained unresolved.
View Article and Find Full Text PDFNasopharyngeal carcinoma (NPC) is prevalent in Southern China. Unfortunately, current treatments encounter multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp), resulting in the efflux of chemotherapy drugs, is one of the significant mechanisms causing MDR.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the relationship between the tumor microbiome and tumor genome, focusing on their potential role in tumor progression and immune response.
- Researchers utilized various data sources, built networks for microbiome and genomic data, and performed correlation analysis to identify specific microbial modules associated with different tumor types.
- Results indicated a significant correlation between the tumor microbiome and genome, suggesting that specific microbes might influence immune responses and could serve as prognostic indicators for cancer outcomes, particularly in relation to TP53 mutations.
Gastric cancer (GC) is a leading cause of mortality and morbidity worldwide. We assessed the expression patterns of DNA damage response (DDR)-related markers, including ATM, CHK2, p-p53 (S15), Rad51, and BRCA2 and autophagy-related proteins including p62 and Beclin-1 in 153 GC specimens using immunohistochemistry staining. GC tissues showed lower levels of ATM, CHK2, p-p53, BRCA2, and higher levels of Rad51 compared to adjacent normal tissues.
View Article and Find Full Text PDFAim: Aptamers are oligonucleic acid or peptide molecules that bind to a specific target molecule in cells, thus may act as effective vehicles for drug or siRNA delivery. In this study we investigated the DNA aptamers that target human glioblastoma multiforme (GBM) cells overexpressing epidermal growth factor receptor variant III (EGFRvIII), which was linked to radiation and chemotherapeutic resistance of this most aggressive brain tumor.
Methods: A 73-mer ssDNA library containing molecules with 30 nt of random sequence flanked by two primer hybridization sites was chosen as the initial library.
Objective: To study the chemical constituents of Gentiana veitchiorum.
Method: The chemical constituents were isolated by chromatography and identified by spectral data.
Result: Five glycosides, loganic acid (1), gentiopicroside (2), isoorientin 3'-methyl ether (3), isovitexin (4), isoorientin (5) were isolated and identified.