Salvinia-Effect-Inspired Magneto-Responsive Superhydrophobic Surfaces with Cluster-Distributed Microcilia Array.

Inspired by the "Salvinia effect", a novel method for fabricating a magneto-responsive superhydrophobic surface coated with a cluster-distributed cilia array (CC-MRSS) was reported. This surface features a magnetically self-assembled nonuniform microcilia array and demonstrates exceptional microdroplet hydrophobicity, magnetic-responsive wettability, and corrosion resistance. The fabrication process involved mixing polydimethylsiloxane (PDMS) and carbonyl iron powders (CIPs), followed by dividing the mixture into two parts.

Simultaneous monitoring of creatinine and urea in diversified clinical samples based on SERS-active PDMS-flower-like ZIF-67@Ag nanoparticles.

The sensitive, efficient, and simultaneous assay of creatinine and urea in different body fluid is crucial for the daily detection and treatment of chronic kidney disease. Here, we exploited a versatile composite surface enhanced Raman scattering (SERS) substrate of polydimethylsiloxane (PDMS)-flower-like ZIF-67@Ag nanoparticles (NPs) based on simple in-situ growth and ion sputtering strategies. The plasmonic Ag NPs assembled on the three-dimensional anisotropic ZIF-67 matrix, facilitating numerous resonant electromagnetic "hotspots".

Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation.

Caseinolytic protease P (ClpP) protein is essential for prokaryotic and eukaryotic protein homeostasis, and has emerged as a promising bactericidal target for controlling bacterial infection and evading the emergent of drug-resistance risk. As the unique bactericidal mechanism, ClpP loses its substrate specificity and undergoes uncontrolled protein hydrolysis in the presence of an activator, leading to causing bacterial death. To further expand the chemotype of ClpP activator, a series of ONC212 derivatives were synthesized using a ring expansion strategy.

12-month outcomes of pulsed-field ablation with a variable-diameter circular catheter for paroxysmal atrial fibrillation: Insights into conscious sedation and fluoroscopy use.

Background: Pulsed-field ablation (PFA) emerges as an innovative nonthermal energy modality for catheter ablation of atrial fibrillation (AF). This study aimed to assess the safety and effectiveness of a novel PFA system that uses a multichannel, circular ablation catheter with adjustable diameters in treating paroxysmal AF.

Methods: This clinical trial (PF-Beat-AF) was a prospective, multicenter, single-arm study.

microRNA-34: A multifunctional miRNA family.

MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. miR-34 is a highly conserved miRNA during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity.

Protective effects of anthocyanins on the nervous system injury caused by fluoride-induced endoplasmic reticulum stress in rats.

Long-term fluoride exposure can produce neurotoxicity. Anthocyanins, as antioxidants, have a certain protective effect in nerve damage. This study aimed to investigate the protective role of anthocyanins in fluoride-induced neurological damage due to endoplasmic reticulum stress (ERS).

PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD.

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the repeat expansion in C9ORF72. Dipeptide repeat (DPR) proteins translated from both sense and antisense repeats, especially arginine-rich DPRs (R-DPRs), contribute to neurodegeneration. Through CRISPR interference (CRISPRi) screening in human-derived neurons, we identified receptor-type tyrosine-protein phosphatase S (PTPσ) as a strong modifier of poly-GR-mediated toxicity.

Latent profiles of psychosocial adaptation in hospitalized persons with stroke and their association with coping styles and illness uncertainty: A cross-sectional study.

Objective: Current studies on psychosocial adaptation of persons with stroke mainly focused on the overall level and ignored its heterogeneity. The aim of the current study was to identify the latent profiles of psychosocial adaptation of persons with stroke and further explore their association with coping styles and illness uncertainty.

Methods: A total of 361 hospitalized persons with stroke were recruited at two affiliated hospitals of a medical university in southeastern China from October 2023 to March 2024.

Postpartum hemorrhage emerges as a key outcome of maternal SARS-CoV-2 omicron variant infection surge across pregnancy trimesters.

Background: Despite evidence showing changes in disease severity with the virus's evolution and vaccination efforts, the link between maternal, perinatal, and neonatal outcomes and SARS-CoV-2 infections during different pregnancy trimesters remains unclear, especially with the BA.5 and BF.7 Omicron subvariant surge in China in December 2022.

The depletion of TFAM and p-β-catenin(S552) in mitochondria in response to BoAHV-1 productive infection leads to decreased mitochondrial biogenesis.

Varicellovirus bovinealpha (BoAHV) types 1(BoAHV-1) is one of the most significant viruses affecting cattle, causing substantial economic losses in the global cattle industry. Virus productive infection in cell cultures leads to mitochondrial dysfunction, resulting in the overproduction of reactive oxygen species (ROS), which act as inflammatory mediators and exert cytotoxic effects. But the underlying mechanisms remain poorly understood.

Filament-woven SF/PA gel for removing ultrafine nanoparticles and unmanageable hazardous pollutants by "all-in-one net".

The current state of the world's water resources is facing serious challenges, and the current water purification processes are designed for a single, more specific contaminant, with more stringent constraints, which are not suitable for emergency water treatment in stochastic environment and may cause secondary pollution. It is necessary to provide a water purification method that is convenient, easy-to-operate, one-step treatment of multiple pollutants. Herein, silk fibroin (SF) that extracted from discarded silkworm cocoons and recycled silk and phytic acid (PA) are "woven" into a network structure through hydrogen bonding and electrostatic interaction to form a unique gel, which could be used to remove different pollutants by "sweeping and catching" and physical adsorption.

Extreme thermophilic microbial inoculation for reducing NH and NO emissions in hyperthermophilic aerobic composting of refinery waste activated sludge.

Ammonia (NH) and nitrous oxide (NO) release are the main causes of nitrogen loss during aerobic composting. In this study, hyperthermophilic aerobic composting of refinery waste activated sludge (RWAS) was performed by adding extreme thermophilic bacteria, and the effects of inoculation on NH and NO emissions were systematically studied. The results revealed that inoculation achieved hyperthermophilic aerobic composting (T group), increased maturity, and reduced NH and NO emissions by 32.

Ferroelectricity and Strong Spin-Orbit Coupling to Enhance Molecular Spin-Electric Coupling.

The electric control of magnetism has been considered to be promising for molecular spintronics and quantum information. However, the spin-electric coupling strength appears to be insufficient for application in most cases. Two major factors capable of amplifying the relative effect are spin-orbit coupling and ferroelectricity.

Green-Solvent Synthesis for In Situ Growth of Perovskite Phosphors without Ligand Assistance.

Cesium-lead halide perovskite nanomaterials have been considered new-generation emitters that can meet the requirements of high photoluminescence efficiency and the high color standard of Rec. 2020. However, their practical application is currently hindered by the challenge of achieving better stability and growth in green solvents.

On-Off Magnetism of Ferromagnetic Metals via Electrochemical Driven Band Filling.

Ferromagnetic metals, distinguished by high Curie temperatures and magnetization, are crucial in voltage-controlled magnetism for potential room-temperature applications in low-power multifunctional devices. Despite numerous attempts based on various mechanisms, achieving ideal magnetic modulation in metals remains challenging. This work proposes a new mechanism to control bulk metal magnetism by modulating valence electron filling in spin-polarized bands, leveraging the Slater-Pauling rule in alloys.

Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models.

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade serous ovarian cancer with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within the tumor and microenvironment.

Single-Bacterium Diagnosis via Terahertz Near-Field Dielectric Nanoimaging.

Single-bacterium diagnostic methods with unprecedented precision and rapid turnaround times are promising tools for facilitating the transition from empirical treatment to personalized anti-infection treatment. Terahertz (THz) radiation, a cutting-edge technology for identifying pathogens, enables the label-free and non-destructive detection of intermolecular vibrational modes and bacterial dielectric properties. However, this individual dielectric property-based detection and the mismatched spatial resolution are limited for the single-bacterium identification of various species of pathogens.

A rhizobacterium-secreted protein induces lateral root development through the IAA34-PUCHI pathway.

Lateral roots (LRs) can continuously forage water and nutrients from soil. In Arabidopsis thaliana, LR development depends on a canonical auxin signaling pathway involving the core transcription factors INDOLE-3-ACETIC ACIDs (IAAs) and AUXIN RESPONSE FACTORs (ARFs). In this study, we identified a protein, bacillolysin, secreted by the beneficial rhizobacterium Bacillus velezensis SQR9, that is able to stimulate LR formation of Arabidopsis.

Synthesis of 2-Organoselenyl Quinolines via Electro-Oxidative Selenocyclization of Isocyanides.

Organoselenium compounds and quinolines are widely used in drugs and materials. Herein, we report an electro-oxidative cyclization between isocyanides and diselenides to effectively synthesize 2-organoselenyl quinolines in a simple undivided cell without transition-metal catalysts or toxic oxidants. Gram-scale synthesis and postsynthetic modifications highlighted the practicality of this electrochemical strategy.

Electricity-Efficient On-Demand Photothermal Activation for Tunable Thermochromic Windows.

Thermochromic (TC) windows with passively controlled sunlight regulation have demonstrated significant building energy conservations. Realizing the active control of the TC window can expand its popularity while remaining an intractable challenge. Herein, a low-power-dissipative strategy that endows TC windows with an actively tunable transmittance is presented through the electro-induced tunable photothermal conversions (ETPCs).

Saline irrigation improves survival of forage sorghum but limits growth and increases toxicity.

Moderately saline water has been proposed as a potential irrigation resource for crops such as forage sorghum (Sorghum bicolor × Sorghum bicolor nothosubsp. drummondii) in drought-prone regions. However, it is not yet fully understood how salinity affects growth and potential toxicity of sorghum.

Effects of different feeding strategies on egg production, eggshell quality, tibial mass and intestinal calcium transporter expression in laying hens.

1. This study examined feeding practices that could affect the expression of intestinal calcium transporter gene, tibial mass, eggshell quality and production performance in 25-week-old Hy-Line Brown Laying Hens.2.

New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space.

Neurochemical imbalance is a contributing factor to neurological symptoms in multiple sclerosis (MS). The matured myelin sheath is crucial for substance transportation within the extracellular space (ECS) and for maintaining local homeostasis. Therefore, we hypothesize that disturbed ECS transportation following demyelinating lesions might lead to neurochemical imbalance in MS.