Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment.

Rationale And Objectives: Alzheimer's disease (AD) is the most common pathogenesis of dementia, and mild cognitive impairment (MCI) is considered as the intermediate stage from normal elderly to AD. Early detection of MCI is an essential step for the timely intervention of AD to slow the progression of this disease. Different form previous studies in the whole-brain spontaneous activities, this research aimed to explore the low-frequency amplitude spectrum activities of patients with MCI within the default mode network (DMN), which has been involved in the process of maintaining normal cognitive function.

The effect of short-term exposure to air pollution on the admission of ischemic stroke and its interaction with meteorological factors.

Objectives: The aim of this study was to investigate the associations, potential effects, and interactions between short-term exposure to air pollution and the risk of ischemic stroke (IS).

Study Design: An ecological study.

Methods: Daily data on IS incidents, air pollution, and meteorological conditions were collected from 2017 to 2021 in Gannan.

Resinacein S ameliorates the obesity in mice via activating the brown adipose tissue.

Brown adipose tissue (BAT) is an ideal target organ for obesity treatment. Resinacein S is extracted from Ganoderma lucidum and can elevate Uncoupling protein 1 (UCP1) in cells, but its related effects at the animal level are not clear. The mice were fed with high-fat diet to construct obesity models and treated with Resinacein S.

Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.

Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation.

Altered zygotic gene expression caused by sperm with variants disrupts early embryonic development.

The precise mechanisms behind early embryonic arrest due to sperm-related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. To investigate the underlying mechanisms and promising therapeutic approaches, knock-in and knock-out mice were generated.

Terahertz Saturable Absorption across Charge Separation in Photoexcited Monolayer Graphene/MoS Heterostructure.

Unveiling the nonlinear interactions between terahertz (THz) electromagnetic waves and free carriers in two-dimensional materials is crucial for the development of high-field and high-frequency electronic devices. Herein, we investigate THz nonlinear transport dynamics in a monolayer graphene/MoS heterostructure using time-resolved THz spectroscopy with intense THz pulses as the probe. Following ultrafast photoexcitation, the interfacial charge transfer establishes a nonequilibrium carrier redistribution, leaving free holes in the graphene and trapping electrons in the MoS.

Rh blood group caused by novel base deletion and comprehensive pedigree analysis.

Objective: The objective of this study was to rigorously investigate and elucidate the genetic mechanisms underlying the formation of the RH blood group in a specific case and to systematically analyse the RH blood group genes among the family members of the proband.

Methods: Serological methods were used to determine the RH blood group phenotype of the proband. To elucidate the underlying genetic mechanism responsible for the RH phenotype, a comprehensive approach was undertaken, including RHCE genotyping, sequencing of RHD and RHCE genes, and exon sequencing of RHAG.

Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling.

The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tissue (aKO) led to a notable rise in mice's mass and adiposity. In contrast, it led to a decline in lean mass, ability to exercise, diameter of muscle fibers, and the levels of genes associated with differentiation.

Efficient and low resistance multi-functional UV resistant polyphenylene sulfide non-woven hollow membrane.

The heat and corrosion resistance of traditional membranes is inadequate, thus making them inadequate for the separation/filtration needs of harsh environments. Polyphenylene sulfide(PPS) can be used to develop new-generation membrane materials, but PPS has problems such as hydrophobicity and UV resistance. This article proposes a PPS membrane for efficient separation/filtration under extreme conditions, which uses melt-blown PPS non-woven fabric and undergoes oxidation and nitrification modification.

SaTDT enhanced plant tolerance to NaCl stress by modulating the levels of malic acid and citric acid in cells.

The issue of soil salinization is a global concern that significantly impairs crop productivity, quality, and distribution. Tonoplast Dicarboxylate Transporter (TDT) is a pivotal malic acid transporter localized on the vacuolar membrane, involving in maintaining intracellular pH homeostasis in plants. However, the molecular mechanisms and regulatory pathways underlying plant salt tolerance through TDT remain elusive.

Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.

Background: Krüppel-like factor 4 (KLF4), a transcription factor, is involved in various biological processes. However, the role of KLF4 in regulating the intestinal epithelial barrier (IEB) in inflammatory bowel disease (IBD) and its mechanism have not been extensively studied.

Methods: KLF4 expression in IBD patients and colitis mice was analyzed using Gene Expression Omnibus(GEO) database, immunohistochemistry (IHC) and Western blot.

Outcome prediction comparison of ischaemic areas' radiomics in acute anterior circulation non-lacunar infarction.

The outcome prediction of acute anterior circulation non-lacunar infarction (AACNLI) is important for the precise clinical treatment of this disease. However, the accuracy of prognosis prediction is still limited. This study aims to develop and compare machine learning models based on MRI radiomics of multiple ischaemic-related areas for prognostic prediction in AACNLI.

Radiomics-based automated machine learning for differentiating focal liver lesions on unenhanced computed tomography.

Background & Aims: Enhanced computed tomography (CT) is the primary method for focal liver lesion diagnosis. We aimed to use automated machine learning (AutoML) algorithms to differentiate between benign and malignant focal liver lesions on the basis of radiomics from unenhanced CT images.

Methods: We enrolled 260 patients from 2 medical centers who underwent CT examinations between January 2017 and March 2023.

Recent progress in carbon nanomaterials for highly flexible fibrous aqueous zinc-ion batteries.

Fibrous zinc-ion batteries (FZIBs) are ideal wearable energy storage devices with unparalleled utility in the next generation of flexible electronics. However, the conventional electrode materials still present challenges to achieve both good electrochemical performance and mechanical deformability. This hinders their large-scale production and commercial application.

Assessment of body composition-related imaging parameters indicative of sarcopenia in Chinese patients with Crohn's disease: correlation with disease severity and biologic efficacy.

Objectives: To evaluate the prognostic value of body composition-related imaging parameters in assessing Crohn's disease (CD) severity and biological responses in Chinese patients.

Methods: We retrospectively analyzed electronic medical records and Computed tomography (CT) images from 117 CD patients, including 90 with sarcopenia and 27 without. We calculated subcutaneous fat area (SFA), visceral fat area, skeletal muscle area (SMA), mesenteric fat index (MFI), skeletal muscle index (SMI), and muscle attenuation (MA).

Nutritional support after hospital discharge reduces long-term mortality in patients after gastric cancer surgery: Secondary analysis of a prospective randomized trial.

Background And Aims: Nutritional support after hospital discharge was found to enhance the nutritional condition of patients after cancer surgery. However, the effect of such support on long-term clinical outcomes is controversial. We thus investigated the effect of nutritional support after hospital discharge on long-term clinical outcomes in patients after gastric cancer surgery.

Association between penultimate ejaculatory abstinence and sperm quality: a cross-sectional study.

Background: Ejaculatory abstinence (EA) duration influences semen parameters. However, the impact of penultimate ejaculatory abstinence (PEA) on conventional and functional sperm parameters remains underexplored.

Method: A cross-sectional study recruited 1,503 men from a reproductive center between November 2023 and July 2024.

Heterogeneity of extracellular vesicles in porcine myoblasts regulates adipocyte differentiation.

The interactions between myogenic cells and adipocytes play an important role in improving carcass traits and the efficiency of energy utilization. However, there are few reports about the interaction between them mediated by small extracellular vesicles (sEV). In this study, sEV derived from porcine primary skeletal muscle stem cells (MuSCs) was found to be involved in the inhibition of porcine primary adipocyte viability, triglyceride content, Oil Red O enrichment and the expression of adipogenic genes.

Novel splicing mutations in PATL2 and WEE2 cause oocyte degradation and fertilization failure.

Purpose: To determine the genetic cause of infertility in two unrelated families of female patients suffering from oocyte degeneration and fertilization failure.

Methods: Whole exome sequencing and Sanger sequencing were performed to identify the disease-causing genes of infertility in two unrelated female patients. Minigene experiments were conducted to confirm the effect of splice site mutations on mRNA splicing.

Facile fabrication of redox nanoparticles loaded with exosomal-miRNAs and resveratrol as glycation inhibitor in alleviating the progression and development of diabetic cataract.

Diabetic cataract (DC) represents a highly prevalent ocular manifestation resulting from diabetes often culminating in vision impairment among individuals with diabetes. Regrettably, the armamentarium of pharmaceutical interventions capable of both delaying and thwarting the onset of DC remains conspicuously sparse. Based on contemporary investigations, the pathogenesis of DC is prominently influenced by oxidative harm to the crystalline lens and the nonenzymatic glycosylation of lens proteins.