To investigate three-dimensional (3D) genome organization in prokaryotic and eukaryotic cells, three main strategies are employed, namely nuclear proximity ligation-based methods, imaging tools (such as fluorescence in situ hybridization (FISH) and its derivatives), and computational/visualization methods. Proximity ligation-based methods are based on digestion and re-ligation of physically proximal cross-linked chromatin fragments accompanied by massively parallel DNA sequencing to measure the relative spatial proximity between genomic loci. Imaging tools enable direct visualization and quantification of spatial distances between genomic loci, and advanced implementation of (super-resolution) microscopy helps to significantly improve the resolution of images.
View Article and Find Full Text PDFOptimized catalysts show great potential for renewable energy storage and conversion. Herein, we report metallic CuCo2S4 nanosheets (NSs) of atomic thickness as efficient bifunctional electrocatalysts for use in portable, flexible Zn-air batteries. The metallic CuCo2S4 NSs of atomic thickness with 4-atom-thick to 6-atom-thick layers are confirmed by temperature-dependent electrical resistance measurements and atomic force microscopy.
View Article and Find Full Text PDFMitogen-activated protein kinase (MAPK) pathways are ubiquitous and evolutionarily conserved signal transduction modules directing cellular respond to a diverse array of stimuli, in the eukaryotic organisms. In this study, was identified to encode a MAPK in , the oomycete pathogen causing litchi downy blight disease. PlMAPK10, containing a specific and highly conserved dual phosphorylation lip sequence SEY (Serine-Glutamic-Tyrosine), represents a novel group of MAPKs as previously reported.
View Article and Find Full Text PDFND2710 is a hard red spring wheat line with a very high level of resistance to Fusarium head blight (FHB). It was selected from the progeny of a cross between ND2603 (an advanced breeding line derived from the Sumai 3/Wheaton cross) and Grandin (a spring wheat cultivar). The FHB resistance of ND2710 is presumably derived from Sumai 3 because the other parents (Grandin and Wheaton) are very susceptible to FHB.
View Article and Find Full Text PDFAlthough transition metal dichalcogenide MoSe is recognized as one of the low-cost and efficient electrocatalysts for the hydrogen evolution reaction (HER), its thermodynamically stable basal plane and semiconducting property still hamper the electrocatalytic activity. Here, it is demonstrated that the basal plane and edges of 2H-MoSe toward HER can be activated by introducing dual-native vacancy. The first-principle calculations indicate that both the Se and Mo vacancies together activate the electrocatalytic sites in the basal plane and edges of MoSe with the optimal hydrogen adsorption free energy (ΔG ) of 0 eV.
View Article and Find Full Text PDFMorphological markers as well as two types of molecular markers, inter-sample sequence repeat (ISSR) and start codon targeted (SCoT) are suitable for species identification of the polygonati rhizoma germplasms. In this paper, we adopted these methods for the identification of rhizomes collected from 47 areas in China. Based on their morphological characters, the collected germplasms were classified into two populations, one with alternate leaf arrangement and the other with verticillate leaf arrangement, and they were comprised of five species and fourteen subgroups.
View Article and Find Full Text PDFLitchi ( Sonn.) is a commercially important fruit but its production and quality are restricted by litchi downy blight, caused by the oomycete pathogen Chen. Volatile substances produced by a biocontrol antinomycetes BWL-H1 could inhibited growth and development both in vitro and in detached litchi leaf and fruit infection assay.
View Article and Find Full Text PDFSensors (Basel)
February 2018
In this paper, a fiber Bragg grating (FBG)-based stress monitoring system instrumented on an orthotropic steel deck arch bridge is demonstrated. The FBG sensors are installed at two types of critical fatigue-prone welded joints to measure the strain and temperature signals. A total of 64 FBG sensors are deployed around the rib-to-deck and rib-to-diagram areas at the mid-span and quarter-span of the investigated orthotropic steel bridge.
View Article and Find Full Text PDFDeveloping convenient doping to build highly active oxygen evolution reaction (OER) electrocatalysts is a practical process for solving the energy crisis. Herein, a facile and low-cost in situ self-assembly strategy for preparing a Ce-doped NiFe-LDH nanosheets/nanocarbon (denoted as NiFeCe-LDH/CNT, LDH = layered double hydroxide and CNT = carbon nanotube) hierarchical nanocomposite is established for enhanced OER, in which the novel material provides its overall advantageous structural features, including high intrinsic catalytic activity, rich redox properties, high, flexible coordination number of Ce, and strongly coupled interface. Further experimental results indicate that doped Ce into NiFe-LDH/CNT nanoarrays brings about the reinforced specific surface area, electrochemical surface area, lattice defects, and the electron transport between the LDH nanolayered structure and the framework of CNTs.
View Article and Find Full Text PDFConstruction of protein-inorganic hybrid materials with hierarchical nanostructures is critical for the creation of advanced multi-functional materials. We herein for the first time report the synthesis of protein-manganese phosphate hybrid nanomaterials by environmentally amiable biomineralization approach. We have demonstrated that collagen provides an excellent biotemplate to modulate the morphology of the hybrid materials, leading to exquisite nanoflowers with branched petals.
View Article and Find Full Text PDFChronic postsurgical pain (CPSP) often occurs after surgery and has a strong impact on patients' daily lives. However, the underlying mechanism of CPSP remains unknown. Here, we used a skin/muscle incision and retraction (SMIR) model to investigate the role of CX3CL1 in SMIR-induced pain and its underlying mechanism.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2018
A polyethylene terephthalate nano porous luminescence fiber (PNPLF) was prepared through electrospun technology. The SEM and TEM images show that the surfaces of the fibers are covered with pores. The diameter of the fiber is 250-500 nm, and the diameter of the pores is 20-180 nm.
View Article and Find Full Text PDFThe development of highly active and stable oxygen evolution reaction (OER) electrocatalysts is crucial for improving the efficiency of water splitting and metal-air battery devices. Herein, an efficient strategy is demonstrated for making the oxygen vacancies dominated cobalt-nickel sulfide interface porous nanowires (NiS /CoS -O NWs) for boosting OER catalysis through in situ electrochemical reaction of NiS /CoS interface NWs. Because of the abundant oxygen vacancies and interface porous nanowires structure, they can catalyze the OER efficiently with a low overpotential of 235 mV at j = 10 mA cm and remarkable long-term stability in 1.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2017
Acute acquired comitant esotropia (AACE) is an unusual presentation of esotropia that occurs after infancy. This study was aimed to study the clinical features and the differences between children and adult patients with AACE in the Chinese populations.This was a retrospective analysis of patients diagnosed with AACE over 4 years; 69 patients (25 females and 44 males) were identified.
View Article and Find Full Text PDFBackground And Objective: Social support is known to be an important protective factor against elder financial exploitation (FE), yet few empirical studies have examined the relationship between FE and distinct components of social support. Perceived social support, social network size, and interactions with close network members (positive and negative) were measured separately and tested as potential predictors of FE.
Research Design And Methods: Three hundred and ninety-five community-dwelling adults aged 60 and older were recruited to complete a 90-minute survey and interview.
Spectrochim Acta A Mol Biomol Spectrosc
February 2018
A photoluminescent terbium (Tb) complex involving a novel benzoic-acid compound with a unique coordinated structure, namely 1,4-bis(carbonylmethyl)terephthalate (BCMT), has been designed and synthesized. The new coordinate structure and energy-transfer mechanism between the ligand and Tb(III) ions were investigated in detail. The results demonstrated that the BCMT-Tb(III) complex shows strong fluorescence intensity (4×10a.
View Article and Find Full Text PDFMicroRNA dysregulation contributes to malignant progression, dissemination, and profound treatment resistance in multiple cancers. miR-449a is recognized as a tumor suppresser. However, the roles of miR-449a in lung cancer initiation and progression are largely unknown.
View Article and Find Full Text PDFAdvances in the development of small photoblinking semiconducting polymer dots (Pdots) have attracted great interest for use in super-resolution microscopy. However, multicolor super-resolution imaging using conventional small photoblinking Pdots remains a challenge due to their limited color choice, broad emission spectrum, and heavy spectrum crosstalk. Here, we introduce two types of small photoblinking Pdots with different colors and relatively narrow emission spectra: blue PFO Pdots and carmine PFTBT5 Pdots for blinking-based statistical nanoscopy.
View Article and Find Full Text PDFIt has been accepted that vitamin D (VD) plays an important role in bone metabolism. However, the levels of VD in people of different regions are quite different and there is still no final conclusion on the significant correlation between VD and osteoporosis. 245 cases of peri-menopausal women were collected to study the relationship between VD and osteoporosis in western China.
View Article and Find Full Text PDFA rational design of highly active and robust catalysts based on earth-abundant elements for hydrogen evolution reaction (HER) is essential for future renewable energy applications. Herein, we report the synthesis of a new class of ultrathin metallic CuFeS nanosheets (NSs) with abundant exposed high-index {02[combining macron]4} facets. They serve as a robust catalyst for the HER with a lower onset potential of 28.
View Article and Find Full Text PDFZhonghua Yi Xue Za Zhi
June 2017
To analyze the relevant factors for diabetic retinopathy. The data of type 2 diabetes mellitus patients undergoing general examination and ophthalmology specialist consultation were collected from the inpatients of Department of Endocrinology in Beijing Airport Hospital between 2013 and 2016, and the relevant factors of diabetic retinopathy were retrospectively analyzed. A total of 432 cases were analyzed, including 168 cases of non-diabetic retinopathy and 264 cases of diabetic retinopathy.
View Article and Find Full Text PDFAim: To establish a Friend murine leukemia virus (FLV)-induced immunodeficient BALB/C mouse model and investigate the effects of Fuzheng Paidu tablets on the body weight, thymus, spleen, and CD4 and CD8 T lymphocytes of FLV-infected mice. FLV was passaged twice in BALB/c mice. The infected mice were divided into six groups of ten mice based on their weights.
View Article and Find Full Text PDFRecently, the stationary high confinement operations with improved pedestal conditions have been achieved in DIII-D [K. H. Burrell , Phys.
View Article and Find Full Text PDFTo investigate the effect of Total Alkali in Leonuri Herba (TALH) on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology. The rats were divided into the TALH group at high, medium and low doses (200 mg kg, 100 mg·kg, 50 mg·kg), the tanshinone group (360 mg·kg), model group and the blank group. All the rats were administrated once a day for 14 days.
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