Iodine staining with distance countdown improving the safety for reduction of adverse events: a randomized controlled trial.

Background: Lugol's chromoendoscopy (LCE) is valuable, cost-effective, and widely used in early esophageal cancer (EEC) screening, yet it suffers from low compliance due to adverse events after LCE. In addition, the reflux of iodine during iodine staining in the upper esophagus brings the risk of bucking and aspiration. We introduced a new model called distance countdown (DC) aimed to reduce reflux during iodine staining in upper esophageal LCE.

Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis.

Insulin resistance was considered to be the most important clinical phenotype of type 2 diabetes (T2DM). Almond is a widely-consumed nut and long-term intake was beneficial to alleviating insulin resistance in patients with T2DM. Hence, screening of anti-diabetic peptides from almond proteins was feasible based on the effectiveness of peptides in the treatment of T2DM.

High-performance ternary logic circuits and neural networks based on carbon nanotube source-gating transistors.

Multi-valued logics (MVLs) offer higher information density, reduced circuit and interconnect complexity, lower power dissipation, and faster speed over conventional binary logic system. Recent advancement in MVL research, particularly with emerging low-dimensional materials, suggests that breakthroughs may be imminent if multistates transistors can be fabricated controllably for large-scale integration. Here, a concept of source-gating transistors (SGTs) is developed and realized using carbon nanotubes (CNTs).

Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.

Cold atmospheric plasma (CAP) has been proposed as an emerging onco-therapeutics that can specifically kill cancer cells without harming healthy cells. Here we explore its potency in triggering ferroptosis in transformed cells using triple negative breast cancer as the disease model. Through the whole transcriptome sequencing, mass spectrometry analysis, point mutation, and a series of and molecular assays, we identified two signaling axes centered at EGFR(Y1068), i.

Improving soil properties and Sesbania growth through combined organic amendment strategies in a coastal saline-alkali soil.

Improving the quality of degraded coastal saline-alkali soil and promoting plant growth are key challenges in the restoration of ecological functions in coastal regions. Organic ameliorants such as effective microbial (EM) agent, biochar, and organic compost have been proposed as sustainable solutions, but limited research has explored the combined effects of these amendments. This study investigates five organic improvement strategies: individual applications of EM, corn straw biochar (CSB), and sewage sludge-reed straw compost (COM), along with combined treatments of CSB + EM and COM + EM, on Sesbania growth in a pot experiment.

Management of neonatal cephalohematoma and ossified cephalhematoma -281 cases of personal 10-year experience.

Objective: Investigate the clinical features and treatment outcomes of neonatal cephalohematoma and ossified cephalohematoma.

Methods: A retrospective review was conducted on the clinical features of 281 children with neonatal cephalohematoma and ossified cephalohematoma managed over the previous 10 years.

Results: Of the neonatal cephalohematomas, 75 underwent puncture and aspiration, while 98 neonatal ossified cephalohematomas were treated with neurosurgery without cranioplasty.

First report of watermelon mosaic virus infecting faba bean ( L.) in China.

Faba bean (Vicia faba L.) is the fourth most cultivated temperate legume (Lyu et al., 2021).

Acute heat stress upregulates Akr1b3 through Nrf-2 to increase endogenous fructose leading to kidney injury.

In recent years, the prevalence of extremely high-temperature climates, has led to an increase in cases of acute heat stress, which has been identified as a contributing factor to various kidney diseases. Fructose, the end product of the polyol pathway, has been linked to kidney conditions such as kidney stones, chronic kidney disease and acute kidney injury. However, the relationship between acute heat stress and kidney injury caused by endogenous fructose remains unclear.

Effect of microplastics on soil greenhouse gas emissions: A global meta-analysis study.

Microplastics (MPs) emerged as a critical global pollutant, yet their effects on soil greenhouse gas (GHG) emissions remain uncertain. This meta-analysis evaluates the effects of MPs exposure on GHG emissions and identifies key influencing factors. Regardless of any influencing factors, MPs exposure decreased NO emissions by 28.

Plane coexistence behaviors for Hopfield neural network with two-memristor-interconnected neurons.

Memristors are commonly used as the connecting parts of neurons in brain-like neural networks. The memristors, unlike the existing literature, possess the capability to function as both self-connected synaptic weights and interconnected synaptic weights, thereby enabling the generation of intricate initials-regulated plane coexistence behaviors. To demonstrate this dynamical effect, a Hopfield neural network with two-memristor-interconnected neurons (TMIN-HNN) is proposed.

Prognostic value of immuno-inflammatory biomarkers in esophageal squamous cell carcinoma patients receiving immunotherapy combined with chemoradiotherapy and its association with immuno-genomic landscape.

Background: The clinical significance of immuno-inflammatory indicators and the underlying biological basis in patients with esophageal squamous cell carcinoma (ESCC) who receive chemoradiotherapy (CRT) combined with immunotherapy remains unclear. This study aims to evaluate the prognostic value of immuno-inflammatory biomarkers, develop a prognostic model, and explore the underlying mechanisms.

Methods: This study included 212 ESCC patients who received CRT and anti-PD-1 immunotherapy.

Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Recurrent Small Hepatocellular Carcinoma: A Randomized, Open-Label, Controlled Trial.

Purpose: To assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC).

Methods: In this trial, patients with recurrent small HCC (single lesion ≤5 cm) were randomly assigned to receive either SBRT or RFA. The primary end point was local progression-free survival (LPFS), and secondary end points were progression-free survival (PFS), overall survival (OS), local control rate, and safety.

Z-Score Experience Replay in Off-Policy Deep Reinforcement Learning.

Reinforcement learning, as a machine learning method that does not require pre-training data, seeks the optimal policy through the continuous interaction between an agent and its environment. It is an important approach to solving sequential decision-making problems. By combining it with deep learning, deep reinforcement learning possesses powerful perception and decision-making capabilities and has been widely applied to various domains to tackle complex decision problems.

Reviving Zn Dendrites to Electroactive Zn by Ion Sieve Interface.

Zn dendrite formation during repeated plating/stripping processes limits the practical use of Zn-metal anodes in reliable and affordable energy storage. Traditional methods, including dendrite suppression and dendrite regulation, fail under demanding performance conditions due to Zn diffusion limitations and concentration gradients. Here, using an in situ pre-zincation approach, a LiZnTiO (LZTO, 0 View Article and Find Full Text PDF

[Maggot alleviates imiquimod-induced psoriasis-like skin lesions in mice by inhibiting immune stress and complement activation].

Objective: To explore the therapeutic mechanism of maggot for psoriasis-like lesions in mice from the perspective of immune stress and complement activation regulation.

Methods: Thirty-six male C57BL/6 mice were randomly divided into control group, model group, maggot (1.25%, 2.

Periodontal bacteria influence systemic diseases through the gut microbiota.

Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut.

Induction chemotherapy plus chemoradiotherapy in esophageal cancer: long-term results and exploratory analyses of a randomized controlled trial.

Background: Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Here, we report long-term results and exploratory analyses to further evaluate the therapeutic value of IC.

Methods: Patients with previously untreated, unresectable, stage II-IVA ESCC were randomly assigned to receive IC followed by CRT or CRT alone.

TCF4 promotes apoptosis and Wnt/β-catenin signaling pathway in acute kidney injury via transcriptional regulation of COX7A2L.

Background: Acute kidney injury (AKI) is still a serious kidney illness with high morbidity and death rates, and it's crucial to comprehend the underlying molecular causes.

Methods: Bioinformatics analysis was performed on GSE139061 and GSE30718 data sets, and COX7A2L was screened out. The role of COX7A2L in H/R-treated cells and its transcriptional regulation with TCF4 were assessed.

Minimal clinically important difference for acupuncture for patients with chronic spontaneous urticaria: secondary analysis from a multicentre randomised controlled trial in China.

Objectives: To evaluate the minimal clinically important difference (MCID) value for acupuncture treatment in chronic spontaneous urticaria (CSU), providing guidance for its application in CSU management.

Design: Secondary analysis of data from a multicentre randomised controlled trial.

Setting: Three tertiary hospitals across three cities in China.

Electronic Structure Engineering of Single-Atom Tungsten on Vacancy-enriched VS Nanosheets for Efficient Hydrogen Evolution.

Constructing single-atom catalysts (SACs) and optimizing the electronic structure between metal atoms and support interactions is deemed one of the most effective strategies for boosting the catalytic kinetics of the hydrogen evolution reaction (HER). Herein, a sulfur vacancy defect trapping strategy is developed to anchor tungsten single atoms onto ultrathin VS nanosheets with a high loading of 25.1 wt.

Evaluation of glucocorticoid-related genes reveals GPD1 as a therapeutic target and regulator of sphingosine 1-phosphate metabolism in CRPC.

Prostate cancer (PCa) is an androgen-dependent disease, with castration-resistant prostate cancer (CRPC) being an advanced stage that no longer responds to androgen deprivation therapy (ADT). Mounting evidence suggests that glucocorticoid receptors (GR) confer resistance to ADT in CRPC patients by bypassing androgen receptor (AR) blockade. GR, as a novel therapeutic target in CRPC, has attracted substantial attention worldwide.