Publications by authors named "Xi Hu"

Aortic aneurysm and dissection pose fatal threats but no effective drug therapies are available. Previous work has been directed to reduce risk factors or target key pathological events, but none of the translational efforts succeeds. Here, we attempt to repurpose dimethyl fumarate (DMF), an FDA-approved immunomodulatory drug for multiple sclerosis, for the treatment of aortic aneurysm and dissection.

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A quadrangular prism-like oxidized tin sulfide catalyst with abundant sulfur vacancies was designed and synthesized for the COER. The quadrangular prism-like structure is utilized to increase the stability, while vacancy engineering is used to improve the activity and selectivity of the catalyst. The catalyst exhibits exceptional electrocatalytic activity for CO reduction to HCOO, achieving up to 95% faradaic efficiency for HCOO and maintaining stability for up to 36 hours at -1.

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Article Synopsis
  • OTUD7B is a deubiquitylase that shows increased expression in breast cancer tissues and is linked to improved patient survival rates.
  • The study investigates OTUD7B's impact on breast cancer cell proliferation and invasion, finding that it interacts with proteins RASGRF1 and PLCE1 to affect the RAS signaling pathway.
  • Silencing OTUD7B leads to reduced RASGRF1 levels and suppresses cancer cell growth and invasion, indicating its potential anti-cancer role in breast cancer.
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Epigenetic-targeted therapy has been applied in the treatment of several types of cancer. Herein, based on the synergistic antitumor effects of co-targeting HDACs and EZH2 in some hematological malignancies, a novel series of tazemetostat-based HDACs/EZH2 dual inhibitors were rationally designed, synthesized, and biologically evaluated. Satisfyingly, compounds 22a and 22b were identified as potent HDACs/EZH2 dual inhibitors with robust antiproliferative activities against one diffuse large-cell B cell lymphomas (DLBCL) cell line harboring EZH2 mutation and multiple acute myeloid leukemia (AML) cell lines.

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This study aimed to discuss the clinical value of health education using an animated video for postoperative patients with digital subtraction angiography (DSA)-guided implantable venous access ports. Retrospective study. Based on expert consensus and clinical experience, we created an animated video presenting postoperative health education for patients to watch after infusion port implantation and uploaded it to a multimedia room.

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Gastric cancer remains a significant global health concern with poor prognosis. This study investigates the role of neutrophils in gastric cancer progression and their potential as prognostic indicators. Using multi-omics approaches, including Weighted Gene Co-expression Network Analysis (WGCNA), machine learning, and single-cell analysis, we identified neutrophil-associated gene signatures and developed a robust prognostic model.

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The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway plays a crucial role in initiating anti-tumor immunity. Despite the development of various STING agonists, their effectiveness is often limited by suboptimal activation efficiency and poor sustainability. To address this, a Mn/MoO nanoagonist featuring Mn single-atom sites is presented, designed for cascade cGAS/STING activation in tumor-specific catalytic metalloimmunotherapy.

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Background: Depression and anxiety are common psychological issues among international medical students in universities, which have serious negative impacts on their learning and life. The present study aimed to evaluate the efficacy of positive emotional writing in alleviating symptoms of anxiety and depression, as well as enhancing subjective well-being among this population.

Method: This study was conducted at an international college of a comprehensive university in central China.

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Objective: The objective of this study is to segment creeping fat and intestinal wall on computed tomography enterography (CTE) and develop a radiomic model to predict 1-year surgery risk in patients with Crohn's disease.

Methods: This retrospective study included 135 Crohn's disease patients who underwent CTE between January and December 2021 (training cohort) and 69 patients between January and June 2022 (test cohort). A total of 1874 radiomic features were extracted from the intestinal wall and creeping fat respectively on the venous phase CTE images, and radiomic models were constructed based on the selected features using the Boruta and extreme gradient boosting algorithms.

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Article Synopsis
  • Renal denervation (RDN) was tested in a sham-controlled trial in China to see if it can effectively lower blood pressure (BP) in hypertensive patients on medication.
  • The study involved 217 participants, showing that those who underwent RDN experienced a significantly greater reduction in 24-hour ambulatory systolic BP (by -13.0 mm Hg) compared to the placebo group (by -3.0 mm Hg).
  • Overall, RDN was found to be safe, as only one minor complication occurred, and it effectively reduced both ambulatory and office BP at the 6-month mark compared to the sham procedure.
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Background: Low serum ceruloplasmin concentration is considered robust marker for Wilson disease (WD) screening, measuring serum ceruloplasmin oxidase activity might be an even more valuable diagnostic tool, but it has not been sufficiently studied.

Methods: All patients who were assessed for serum ceruloplasmin oxidase activity between January 1, 2016, and September 2, 2019, were enrolled in this study. The diagnostic performance of serum ceruloplasmin oxidase activity was analyzed using receiver operating characteristic curve analysis (ROC), Spearman's rank correlation, and Mann-Whitney U test.

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Polyphenols are a group of naturally occurring compounds that possess a range of biological properties capable of potentially mitigating or preventing the progression of age-related cognitive decline and Alzheimer's disease (AD). AD is a chronic neurodegenerative disease known as one of the fast-growing diseases, especially in the elderly population. Moreover, as the primary etiology of dementia, it poses challenges for both familial and societal structures, while also imposing a significant economic strain.

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Cyanobacteria have great potential in CO-based bio-manufacturing and synthetic biological studies. The filamentous cyanobacterium, sp. strain BL0902, is comparable to () in commercial-scale cultivation while proving to be more genetically tractable.

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Aqueous zinc-ion batteries (AZIBs) are competitive alternatives for large-scale energy-storage devices owing to the abundance of zinc and low cost, high theoretical specific capacity, and high safety of these batteries. High-performance and stable cathode materials in AZIBs are the key to storing Zn. Manganese-based cathode materials have attracted considerable attention because of their abundance, low toxicity, low cost, and abundant valence states (Mn, Mn, Mn, and Mn).

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Objective: The study aims to investigate the causal relationship between cheese intake and caries occurrence by a two-sample Mendelian randomization method (TSMR).

Methods: Data from a genome-wide association study (GWAS) on cheese intake as an exposure factor were collected, and dental caries was the outcome variable, appropriate SNPs were selected as instrumental variables (IVs). The TSMR was analyzed by the inverse variance weighting (IVW) method, weighted median method, MR-Egger regression method, simple model and weighted model.

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To overcome current limitations in photoimmunotherapy, such as insufficient tumor antigen generation and a subdued immune response, a novel photo-/metallo dual-mode immunotherapeutic agent (PMIA) is introduced for potent near-infrared (NIR) light-triggered cancer therapy. PMIA features a dumbbell-like AuPt heterostructure decorated with starry Pt nanoclusters, meticulously engineered for enhancing plasmonic catalysis through multi-dimensional regulation of Pt growth on Au nanorods. Under NIR laser exposure, end-tipped Pt nanoclusters induce efficient electron-hole spatial separation along the longitudinal axis, resulting in radial and axial electron distribution polarization, conferring unique anisotropic properties to PMIA.

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Acute myeloid leukemia (AML) is a hematopoietic malignancy with a high relapse rate and progressive drug resistance. Alternative polyadenylation (APA) contributes to post-transcriptional dysregulation, but little is known about the association between APA and AML. The APA quantitative trait locus (apaQTL) is a powerful method to investigate the relationship between APA and single nucleotide polymorphisms (SNPs).

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Cancer cells rely on aerobic glycolysis and DNA repair signals to drive tumor growth and develop drug resistance. Yet, fine-tuning aerobic glycolysis with the assist of nanotechnology, for example, dampening lactate dehydrogenase (LDH) for cancer cell metabolic reprograming remains to be investigated. Here we focus on anaplastic thyroid cancer (ATC) as an extremely malignant cancer with the high expression of LDH, and develop a pH-responsive and nucleus-targeting platinum nanocluster (Pt@TAT/sPEG) to simultaneously targets LDH and exacerbates DNA damage.

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Large-scale marine heatwaves in the Northeast Pacific (NEP), identified here and previously as 'warm blobs', have devastating impacts on regional ecosystems. An anomalous atmospheric ridge over the NEP is known to be crucial for maintaining these warm blobs, also causing abnormally cold temperatures over North America during the cold season. Previous studies linked this ridge to teleconnections from tropical sea surface temperature anomalies.

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Background Right atrial (RA) function strain is increasingly acknowledged as an important predictor of adverse events in patients with diverse cardiovascular conditions. However, the prognostic value of RA strain in patients with dilated cardiomyopathy (DCM) remains uncertain. Purpose To evaluate the prognostic value of RA strain derived from cardiac MRI (CMR) feature tracking (FT) in patients with DCM.

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This study employs a multifaceted approach, encompassing field investigations, borehole surveys, surface deformation displacement monitoring, deep-seated deformation monitoring, and numerical simulation analysis, to conduct an exhaustive examination of the deformation processes and characteristics exhibited by the Mala Landslide. The findings elucidate a close correlation between the deformation of the Mala Landslide and the elevation of the reservoir water level. During the escalation of the reservoir water level, the landslide body progressively developed surface cracks, spanning from the frontal edge to the rear edge.

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Layered sodium vanadium materials have aroused increasing interest owing to their open layered structures and high theoretical capacity. Nevertheless, the strong electrostatic interactions between vanadium oxide layers and intercalated Zn and the weak electronic conductivity severely limit their further development. Here, we design a series of cobalt ion-doped sodium vanadium electrode materials with nanoflower-like morphologies.

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