Ultra-Narrowband Green-Emitting Transparent Composite Ceramics for Laser-Driven Display.

Laser-driven projection displays face a critical challenge in developing laser-excitable and high-performance narrowband green emitters. Herein, new AlO-LaMgAlO: Mn (AlO-LMA: Mn) transparent composite ceramics are reported via high-temperature vacuum sintering, which produces a high-color-purity (95.4%) green emission with full width at half maximum of 24 nm and superior thermal and moisture and laser irradiation stability.

Size-exclusion chromatography as a multi-attribute method for process and product characterization of adeno-associated virus.

Adeno-associated viruses (AAVs) have recently emerged as a leading platform for gene therapy. Due to the complex manufacturing process and structural features of AAVs, extensive process and product characterization studies are required to better understand product quality and batch-to-batch variability. It is, therefore, critical to develop a fast and reliable analytical method to monitor different product quality attributes (PQAs) of AAVs.

Transcriptional patterns of brain structural abnormalities in CSVD-related cognitive impairment.

Background: Brain structural abnormalities have been associated with cognitive impairment in individuals with small cerebral vascular disease (CSVD). However, the molecular and cellular factors making the different brain structural regions more vulnerable to CSVD-related cognitive impairment remain largely unknown.

Materials And Methods: Voxel-based morphology (VBM) was performed on the structural magnetic resonance imaging data of 46 CSVD-related cognitive impairment and 73 healthy controls to analyze and compare the gray matter volume (GMV) between the 2 groups.

Decreased Cortical Sulcus Depth in Parkinson's Disease with Excessive Daytime Sleepiness.

Introduction: Excessive daytime sleepiness (EDS), a prevalent non-motor symptom in Parkinson's disease (PD), significantly impacts the quality of life for PD patients and elevates the risks of injury. Our study is to investigate the altered cortical surface morphology characteristics in PD patients with EDS (PD-EDS).

Methods: Clinical data and magnetic resonance imaging were obtained from the Parkinson's Progression Marker Initiative database, comprising 36 PD-EDS and 98 PD patients without EDS (PD-nEDS).

Biological activity of alkaloids from kenaf bast fibres.

Alkaloids are a kind of important antibacterial components in plants. In order to explore its biological activity of alkaloids from kenaf bast fibres, the alkaloids were extracted from kenaf bast fibres and then its antibacterial activity has been evaluated in this study. The total content of crude alkaloids was 46.

Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients.

Aims: The study attempted to determine the underlying role and regulation mechanism of 3β-hydroxysterol-Δ24 reductase (DHCR24) in the pathophysiology of cerebral small vessel disease-associated cognitive impairment (CSVD-CI). An RNA high-throughput sequencing and independent verification were conducted to identify potential circRNAs becoming the upstream regulator.

Methods: RNA sequencing was performed in whole-blood samples in cohort 1 (10 CSVD-CI and 8 CSVD with cognitively normal [CSVD-CN] patients).

Collagen signature adds prognostically significant information to staging for breast cancer.

Background: Tumor-associated collagen signature (TACS) is an independent prognostic factor for breast cancer. However, it is unclear whether the complete collagen signature, including TACS, the TACS-based collagen microscopic features (TCMF1), and the TACS-based nuclear features (TCMF2), can provide additional prognostic information for the current tumor-node-metastasis (TNM) staging system.

Patients And Methods: We included 941 patients with breast cancer from three cohorts: the training (n = 355), internal (n = 334), and external validation cohorts (n = 252).

Pine Needle of Pinus koraiensis (Siebold & Zucc) Essential Oil Through Liquid Nitrogen Quick-Freezing Assisted Solvent-Free Microwave Extraction Process for Antibacterial Application.

Introduction: This study investigates the composition and antibacterial properties of essential oil extracted from Pinus koraiensis (Siebold & Zucc) pine needles using a liquid nitrogen freezing treatment combined with solvent-free microwave extraction (LNSFM).

Objective: The aim is to develop a low-energy, high-efficiency extraction method for conifer essential oils, analyze their chemical composition, and evaluate their antibacterial efficacy.

Methodology: Pine needle samples were frozen with liquid nitrogen and subsequently crushed.

Comparing white and gray matter responses to lobar intracerebral hemorrhage in piglets and the effects of deferoxamine.

Background: Intracerebral hemorrhage (ICH) often impacts patient white matter. However, preclinically, the effects of ICH are mostly studied in rodents with sparse white matter. This study used a lobar porcine ICH model to examine differences in the effects of ICH on white and gray matter as well as the role of the iron chelator deferoxamine (DFX), on attenuation of such injury.

In Situ Deprotection-Free Synthesis of Silver/Graphdiyne with a High Raman Sensing Effect for Detection of Polychlorophenols and Microplastics.

Since the first synthesis of graphdiyne (GDY), it has been widely receiving a lot of attention and has great application prospects in many fields, such as energy storage, catalysis, and sensing. However, the complex deprotection treatment and long reaction time limit its mass production and applications. Here, we present a strategy for the silver-catalyzed deprotection-free rapid synthesis of GDY.

AutoLNMNet: Automated Network for Estimating Lymph-Node Metastasis in EGC Using a Pyramid Vision Transformer and Data Derived From Multiphoton Microscopy.

Lymph-node status is important in decision-making during early gastric cancer (EGC) treatment. Currently, endoscopic submucosal dissection is the mainstream treatment for EGC. However, it is challenging for even experienced endoscopists to accurately diagnose and treat EGC.

The contribution of adiponectin to diabetic retinopathy progression: Association with the AGEs-RAGE pathway.

Diabetic retinopathy (DR) is a chronic complication of diabetes. Given that adiponectin plays a key role in DR progression, this study aims to elucidate the molecular mechanisms of sDR progression related to adiponectin. First, we extracted the microarray dataset GSE60436 from the Gene Expression Omnibus (GEO) database to identify hub genes associated with DR.

Producing Freestanding Single-Crystal BaTiO Films through Full-Solution Deposition.

Strontium aluminate, with suitable lattice parameters and environmentally friendly water solubility, has been strongly sought for use as a sacrificial layer in the preparation of freestanding perovskite oxide thin films in recent years. However, due to this material's inherent water solubility, the methods used for the preparation of epitaxial films have mainly been limited to high-vacuum techniques, which greatly limits these films' development. In this study, we prepared freestanding single-crystal perovskite oxide thin films on strontium aluminate using a simple, easy-to-develop, and low-cost chemical full-solution deposition technique.

Two-Orders-of-Magnitude Enhancement of SERS Activity via a Simple Surface Engineering of Quasi-Metal Single-Crystal Frameworks.

Beyond noble metals and semiconductors, quasi-metals have recently been shown to be noteworthy substrates for surface enhanced Raman spectroscopy, and their excellent quasi-metal surface-enhanced Raman spectroscopy (SERS) sensing has demonstrated a wider range of application scenarios. However, the underlying mechanism behind the enhanced Raman activity is still unclear. Here, we demonstrate that surface hydroxyls play a crucial role in the enhancement of the SERS activity of quasi-metal nanostructures.

Quality characterization of tobacco flavor and tobacco leaf position identification based on homemade electronic nose.

A set of nine unique tobacco extract samples was analyzed using a self-developed electronic nose (E-nose) system, a commercial E-nose, and gas chromatography-mass spectrometry (GC-MS). The evaluation employed principal component analysis, statistical quality control, and soft independent modeling of class analogies (SIMCA). These multifaceted statistical methods scrutinized the collected data.

An Acid-Activatable Fluorescent Probe for Sulfur Dioxide in Traditional Chinese Medicines and Living Cells.

Excessive sulfur dioxide (SO₂) disturbs physiology of lysosomes causing diseases and threatening human health. A fluorescent probe has been regarded as one of the most attractive approaches, which is compatible with living cells and possesses high sensitivity. However, most of fluorescent probes' reaction sites are activated before they reach the destination.

Ovarian cancer identification technology based on deep learning and second harmonic generation imaging.

Ovarian cancer is among the most common gynecological cancers and the eighth leading cause of cancer-related deaths among women worldwide. Surgery is among the most important options for cancer treatment. During surgery, a biopsy is generally required to screen for lesions; however, traditional case examinations are time consuming and laborious and require extensive experience and knowledge from pathologists.

Development of novel antivrial agents that induce the degradation of the main protease of human-infecting coronaviruses.

The family of human-infecting coronaviruses (HCoVs) poses a serious threat to global health and includes several highly pathogenic strains that cause severe respiratory illnesses. It is essential that we develop effective broad-spectrum anti-HCoV agents to prepare for future outbreaks. In this study, we used PROteolysis TArgeting Chimera (PROTAC) technology focused on degradation of the HCoV main protease (M), a conserved enzyme essential for viral replication and pathogenicity.

Formation of Multinucleated Giant Cells after Experimental Intracerebral Hemorrhage: Characteristics and Role of Complement C3.

Hematoma clearance is critical for mitigating intracerebral hemorrhage (ICH)-induced brain injury. Multinucleated giant cells (MGCs), a type of phagocyte, and the complement system may play a pivotal role in hematoma resolution, but whether the complement system regulates MGC formation after ICH remains unclear. The current study investigated the following: (1) the characteristics of MGC formation after ICH, (2) whether it was impacted by complement C3 deficiency in mice and (3) whether it also influenced hematoma degradation (hemosiderin formation).